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Pharmacology Test 4 > TCAs > Flashcards

Flashcards in TCAs Deck (7)
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1
Q

TCAs: name them

A
  • amitriptyline
  • doxepin
  • mirtazapine
2
Q

TCAs: MOA

A
  • block neuronal uptake of 2 monoamine NTs: NE and 5-HT
    • inc conc of these at CNS synapses and instensify there effects
  • biochemical effects w/in hours, therapeutic effects w/in a few weeks
3
Q

TCAs: indication

A
  • depression
  • bipolar disorder
  • fibromyalgia syndrome
  • neuropathic pain
  • chronic insomnia
  • ADHD
  • panic disorder
  • OCD
4
Q

TCAs: SEs

A
  • orthostatic hypotension
  • anticholinergic effects: blurred vision, urinary retention, dry mouth, constipation, anhydrosis, tachycardia)
  • diaphoresis
  • sedation (b/c of blockade of histamine receptors in CNS)
5
Q

TCAs: ADRs

A
  • cardiac toxicity: dec vagal influence, act on Bundle of His to slow conduction
  • seizures
  • hypomania
  • suicide risk
6
Q

TCAs: nursing implications

A
  • contraindicated if pt taking another MAOI, after an MI
  • w/ hypoTN: make sure pts move slow and get up slowly
    • monitor BP and pulse 4x/day for hospitalized pts
      • take while lying down and again after sitting/standing for a minute–if BP low or pulse high, then withhold med and notify provider
  • inform pt that no effects will develop until 1-3 weeks
    • should use 4-9 mos even if feel cured
  • caution in pts with heart problems, urinary retention, seizures
  • do not d/c abruptly
  • do not use alcohol or other CNS depressants
  • do not use other anticholinergic drugs
7
Q

doxepin: contraindications

A
  • glaucoma
  • tendency to urinary retention