TDM

Question 1

The analysis, assessment and evaluation of circulating concentrations of drugs in serum, plasma, or whole blood

Answer 1

therapeutic drug monitoring

Question 2

biochemical pathway responsible for the greatest portion of drug metabolism

Answer 2

MFO system

Question 3

100% bioavailability

Answer 3

intravenous (IV)

Question 4

0.7% bioavailability

Answer 4

oral administered drug

Question 5

inhalation

Answer 5

asthma

Question 6

release of drug

Answer 6

liberation

Question 7

transport of drug from the site of administration to the blood

Answer 7

absorption

Question 8

these type of drugs requires dissolution being being absorbed

Answer 8

tablets and capsule

Question 9

absorbed in the stomach

Answer 9

weak acid

Question 10

absorbed in the intestines

Answer 10

weak base

Question 11

factors affecting absorption

Answer 11

1. pH
2. Inflammation
3. Presence of food & other drugs
4. Changes in intestinal movement

Question 12

delivery of the drug to the tissues

Answer 12

distribution

Question 13

location where the drugs are effective

Answer 13

body tissues (not blood)

Question 14

drug diffuse throughout the body from ___ concentration to ___ concentration

Answer 14

high, low

Question 15

process of chemical modification by the cells

Answer 15

metabolism

Question 16

relationship between the tissue and blood levels

Answer 16

distribution space

Question 17

process in which drug metabolite is excreted by the body

Answer 17

excretion

Question 18

Dependent not only on the type of drug itself but
also to the patientʼs capacity to metabolize and excrete

Answer 18

rate of clearance

Question 19

all drugs are excreted from ___

Answer 19

urine

Question 20

site where conversion of parent drug to its metabolite occurs

Answer 20

liver

Question 21

enzyme responsible for drug conversion

Answer 21

hepatocyte cytochrome P450

Question 22

Fraction of the dose that reaches the blood

Answer 22

Bioavailable fractions F

Question 23

• represents the dilution of the drug after it is distributed in the body
• Used to estimate the peak drug blood level after the dose is given
• the principal determinant of the dose

Answer 23

Vd (D)

Question 24

drugs that are transported to the liver lost a
fraction of its bioavailability before the drug reaches the general circulation

Answer 24

First pass hepatic metabolism

Question 25

represents a linear relationship between the drug amount eliminated per hour and blood level of the drug

Answer 25

First order elimination

Question 26

the time required to reduce a drug level to half of its initial value

Answer 26

Half life (t 1/2)

Question 27

highest concentration of drug obtained in the dosing interval.

Answer 27

peak concentration

Question 28

the relationship between **drug concentration** at the target site and **response to the tissue**

Answer 28

pharmacodynamics

Question 29

**study of genes** that affects the performance of a drug in an individual

Answer 29

pharmacogenomics

Question 30

the mathematical expression of the relationship between drug doses and drug level

Answer 30

pharmacokinetics

Question 31

ratio between the **minimum** toxic and **maximum** therapeutic serum concentration.

Answer 31

therapeutic index

Question 32

difference between the highest and lowest effective dosage.

Answer 32

therapeutic range

Question 33

the lowest concentration of a drug obtained in the dosing interval.

Answer 33

trough concentration