TEAS anatomy Flashcards

(574 cards)

1
Q

coronal plane

A

frontal plate
posterior and anterior

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2
Q

sagittal plane

A

left and right halves

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3
Q

ventral

A

anterior

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4
Q

dorsal

A

posterior

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5
Q

trunk aka

A

torso

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6
Q

trunk includes

A

pelvis, abdomen, chest

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7
Q

what controls the temperature and humidity of air into body

A

respiratory sytem. important function.

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8
Q

what is more superior, thyroid cartilage or cricoid cartilage?

A

cricoid is inferior to thyroid cartilage

think how feelings swallow is kind of further up

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9
Q

respiratory biggest to smallest

A

nasal vestibule–> nasal cavity–>pharynx
or
oral cavity –> pharynx

pharynx–>larynx (epiglottis)–>larynx (vocal folds) –> trachea –> trachea carina –> bronchi –> lobar bronchus –>lingular division bronchi

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10
Q

Lobar bronchus left versus right

A

right: superior, inferior, middle
left: superior, inferior

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11
Q

left lung

A
  • cardiac notch
  • apex at the top
  • oblique fissure
  • lingula of the lung is the notch created by the cardiac notch
  • just a superior and inferior lobe
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12
Q

right lung

A
  • superior lobe
  • middle lobe
  • inferior lobe
  • horizontal AND oblique fissue
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13
Q

structures of alveoli

A

an alveolar duct that is surrounded by mucosal gland and mucusal lining. pulmonary A&V wrapped around the outside of the duct that then form webs around the alveolar sacs. the atrium is the empty space that the balloons hang out while the alveolar sacs are the balloons.

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14
Q

nasal conchae

A

the hard structures inside of the nasal cavity (superior, middle, inferior)

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15
Q

Upper respiratory tract

A

nose, sinus, pharynx, larynx

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16
Q

Lower respiratory tract

A

trachea, bronchi, lungs

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17
Q

Respiration

A

respiration is more than just breathing. It’s the process of using oxygen to break down food for energy

Internal and External respiration

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18
Q

Internal respiration

A

Internal respiration involves the transport of oxygen to all the tissues and cells in the body through the blood

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19
Q

External respiration

A

external respiration, or getting oxygen from the external environment into the body. Once the oxygen enters the lungs, oxygen diffuses into the blood.

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20
Q

Cellular respiration

A

occurs inside where oxygen is used to break glucose molecules down for energy. The blood then transports the waste product, carbon dioxide, back to the lungs where it is exhaled.

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21
Q

Accessory muscles for respiration

A

he intercostal muscles and accessory muscles can also be used to enable greater expansion.

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22
Q

Ventilation

A

The rate at which gas enters or leaves the lungs is called ventilation

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23
Q

How is the resp system controlled by the nervous system

A

rate of ventillation is controlled by the autonomic nervous system, specifically by the medulla oblongata and pons.

If the level of carbon dioxide in the blood increases, this is detected by receptors in the:
aorta, carotid artery, and medulla. A signal is then sent to increase the rate of breathing to remove excess CO2
.

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24
Q

CF cause

A

genetic

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25
allergies causes
both genes and environment
26
asthma causes
genetic and environmental
27
conditions caused by exposure to pollutants
COPD, emphysema, mesothelioma, lung cancer
28
hepatic circulation
hepatic vein carries blue blood to the vena cava hepatic artery carries red blood to the liver hepatic portal vein carries deoxy blood from stomach and intestines to the liver, which is then carried back to the hepatic vein and then the vena cava
29
how long do red blood cells live
4 months ## Footnote platelets are 1 week
30
what is the pulmonary trunk
the archway for the pulmonary arteries before they split off into 4. carries deoxy blood. its sent to the lungs for oxygenation. vena cava also carries deoxy blood but its to the heart.
31
Mitral valve
on the left side of the heart also bicuspid has to deal with increased back pressure from the aorta
31
tricuspid valve
on the right side of the heart
31
Semilunar valves
are present in BOTH the aortic valve and the pulmonary valve (the two big pumps moving blood away)
32
right atrium
recieves blood from the body
33
left atrium
recieves blood from the lungs
34
Two circuits of blood flow
pulmonary and systemic pulmonary is low O2 to high O2, middle is lungs systemic is high O2 to low O2, middle is body
35
normal systolic and diastolic
under both 120 and 80
36
Digestive system includes
salivary glands, parotid glands, sublingual glands, submandibular glands, mouth, tongue **pharynx**, esophagus, liver, gallbladder, stomach, spleen, pancreas SI LI anus
37
structure of the SI
1 duodenum 2 jejunum 3 ileum
38
structure of the LI
1. appendix 2. ascending colon 3. transverse colon 4. descending colon 5. sidmoid colon 6. rectum 7. anal canal 8. anus
39
Alimentary canal
In the digestive system, the one-way pathway through which food travels is called the alimentary canal. Mouth, esophagus, stomach, duogenum, large intestine, anus. mouth and stomach digest mechanically It does not include accessory organs.
40
accessory organs of the digestive system
does not include alimentary canal liver, salivary glands, gallbladder, pancreas
41
digestive system overall function
break down and absorb
42
pepsin
proteins break down
43
amylase secreted by the pancreas
carbs break down secreted by pancreas
44
chemical digestion
saliva, stomach acid, liver enzymes, pancreas enzymes
45
lipase
secreted by pancreas
46
nuclease & proteolytic enzymes ## Footnote proteolitic enzymes break down protein and nuclease breaks down nucleotides
secreted by the pancreas
47
Bile
secreted by the liver and stored in the gallbladder for digestion breaks down fats
48
Functions of the liver
remove toxins metabolism digestion
49
Neuromuscular system
CNS and PNS combined
50
how many neurons does the brain have
100 million
51
where does spinal cord begin and end
base of skull, through vertebral column, ending between 1st and 2nd lumbar vertebrae
52
PNS is divided into | and what does it include?
somatic and autonomic nervous systems includes the cranial and spinal nerves (not the spinal CORD)
53
afferent, efferent, interneurons
afferent sensory signals arrives at the brain efferent signals exit the brain and go to the muscles interneurons go between
54
muscle cells contain what
muscle fibers
55
Smooth muscle
found in blood vessels the eyes bladder, intestine, digestive, urinary, uterus uses peristalsis
56
FSH and LH do what in the testes
During puberty, the testes respond to the release of FSH (follicle-stimulating hormone) and LH (luteinizing hormone) to begin the production of active sperm. testes also create testosterone for males
57
Flow of sperm & seminal fluid
semen: testes-->epididymis --> ductus (vas) deferens --> ampulla --> ejaculatory duct seminal fluid: seminal vesicle-->ejaculatory duct prostate also leads to ejaculatory duct urethra: ejaculatory duct-->prosthatic urethra-->membranous urethra-->spongy urethra-->external urethral opening lubricate and prepare for urethral ejaculation by making things acidic to cancel out basic: bulbourethral gland--> spongy urethra Bulbosaur casts acid
58
what happens during female puberty
During puberty, the ovaries respond to FSH and LH to begin releasing egg cells on a monthly basis. ovaries create eggs similar to how testes create sperm.
59
broad ligament
ties down the uterus to the pelvic muscle
60
ovarian ligament
ovary to uterus
61
The main female sex hormones
estrogen, progesterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) regulate the menstural cycle
62
female hormone that stimulates changes during puberty
estrogen
63
pituitary gland
found in the brain and controls the release of FSH, LH, and oxytocin
64
ovaries
produce estrogen and progesterone
65
epidermis layers
top to bottom: stratum corneum, lucideum, granulosum, spinosum, basale Come, Lets Get Sun Burned
66
hypodermis
body fat
67
dermis
muscular tissue, follicles and hair roots, nerve endings, vessels, glands, and connective tissue
68
integumentary system
* acts as a barrier and protects the body from damage. * It also excretes waste substances, such as sweat * regulate body temperature * vitamin D synthesis * Sensory receptors for the detection of pain, pressure, and temperature * maintain homeostasis: narrow blood vessels in dermis to prevent heat loss and excrete sweat through glands to cool the body
69
Endocrine system of the brain
Hypothalamus, pineal gland, pituitary
70
endocrine system of the throat
thymus, thyroid, parathyroid
71
endocrine in the abdomen and pelvis
adrenal, pancreas, ovaries, testes
72
what is produced in the adrenal medulla
catecholamines (dopamine, norepinepine, epineprine)
73
excretory system includes
skin, lungs, rectum
74
lymphatic system
adenoids, tonsil, thymus, lymph nodes, spleen, BM
75
first line defense ## Footnote of immune system
occur before a pathogen can enter the bloodstream and include the skin, saliva, mucous membranes, hair, and stomach acid.
76
second line defense
innate immune cells in the bloodstream
77
third line defense
adaptive immune cells that target specific pathogens
78
axial skeleton
skull, vertebral column, and rib cage
79
appendicular skeleton
pelvis, shoulders, limbs
80
flat bones
thin bones that protect organs and join other bones together, such as the skull and shoulder blades.
81
short bones
same width and length and offer limited mobility. The wrist and ankle bones are short bones.
82
sesamoid bones
small and round, and they are located in tendons to help strengthen joints that are often compressed, like the patella in the knee joint
83
Irregular bones
unique shape, like the vertebrae, for example
84
Pivot joints vs hinge
Pivot joints, like the neck bones, allow back-and-forth rotation. Hinge will bend and straighten in one direction like the elbow.
85
Ellipsoidal joints
in the wrists, allow back-and-forth and up-and-down motion.
86
Compact bone
The outer layer of bone and it has networks of arteries and veins running through it.
87
spongy bone
inner layer The holes and spaces in the spongy bone allow the bone to be strong without being as heavy as solid bone would be. It also allows room for the bone marrow, which produces red and white blood cells and platelets.
88
Bones function
framework for the body itself, protect organs, produce red and white blood cells in the marrow, and store calcium, iron, and fat.
89
Right hypochondriac
right kidney, liver, gallbladder, and small intestine
90
Epigastric
stomach, liver, adrenal glands, pancreas, spleen, small intestine
91
Left hypochondriac
left kidney, spleen, pancreas, and colon
92
right lumbar
ascending colon, liver, gallbladder
93
umbilical
small intestine, duodenum, umbilicus
94
left lumbar
descending colon, left kidney
95
right iliac
cecum, appendix
96
hypogastric
bladder, female internal reproductive organs, sigmoid colon
97
left iliac
descending and sigmoid colon
98
abdominal cavity
liver, stomach, pancreas, spleen, gallbladder, intestine and **kidney** | ventral body cavity
99
pelvic cavity
bladder, sex organ, large intestine's sigmoid colon and rectum ## Footnote ventral body cavity
100
peritoneal cavity
## Footnote ventral body cavity
101
thoracic cavity
bove the diaphragm and contains the lungs and the mediastinum, which separates the cavity into a right and left compartment. The heart, trachea, esophagus, and thymus gland lie within the mediastinum. | ventral cavity
102
dorsal cavity
contains the brain and spinal cord, located on the dorsal side.
103
cranial cavity
brain, the 12 cranial nerves, and the pituitary gland.The meninges (comprised of the dura mater, arachnoid mater, and pia mater) line the cavity and surround the brain and the spinal cord and contain CSF between the arachnoid mater and pia mater
104
layers of brain
1. pia mater is vascularized on the surface of brain and spinal cord 2. middle layer is arachnoid - not vascularized or nerves. just CT 3. vascularized dura mater most superficial and separates brain into compartments. (endosteal lines cranial bones, meningeal layer lines vertebral cavity)
105
vertebral cavity
vertebrae and spinal cord
106
conductive vs respiratory zone
respiratory is where actual gas exchange occurs
107
external vs internal respiration
External respiration is the exchange of gas between the lungs and the blood. Internal respiration is the exchange of gas between the blood and tissues.
108
secondary functions of respiratory system
pH regulation of the blood, thermoregulation, odor detection, and the production of speech.
109
What ig is in mucosal lining in respiratory tract
IgA
110
lung from big to small
Each primary bronchus splits repeatedly into secondary bronchi, tertiary bronchi, and bronchioles to form the bronchial tree. The terminal bronchioles further divide into respiratory bronchioles, which are characterized by the presence of some alveoli. The respiratory bronchioles lead into alveolar ducts, which terminate in alveolar sacs.
111
what type of cells are in alveoli
type 1 squamous cells single layer lines the alevoli wall and they make up the majority. type 1 participates in gas exchange. type 2 cells are cuboidal that secrete surfactant to prevent alvoeli from collapsing. the alveolar walls are perforated in case of blocked ducts. there's also macrophages (lysosomes and cilia are located in upper respiratory tract)
112
how do capillary walls interact with alveoli
the basement membrane fuses together to form the respiratory membrane
113
expiration vs inspiration which is passive
expiration is passive. inspiration is using negative pressure breathing by contracting the diaphragm
114
cellular respiration formula
glucose + 6O2 --> 6CO2 + 6H20
115
how does O2 and CO2 travel
most O2 binds to hemoglobin in RBCs. some dissolves in the blood. Most CO2 is in the form of bicarb. some dissolves in the blood but some can also bind to hemoglobin.
116
True or false, lipids can travel in blood by themselves
false. must use a carrier protein
117
how is thermoregulation controlled by the brain
hypothalamus is the thermometer
118
Epicardium, myocardium, endocardium
epicardium, which protects the heart and secretes lubricating serous fluid. The middle layer is the muscular myocardium, which contracts to pump blood. The innermost layer is the endocardium, which lines the chambers and valves.
119
Endothelium - composition | found in blood BV and heart
* single layer of squamous endothelial cells that are connected by tight junctions and adherens junctions. This allows the endothelium to act as a selectively permeable barrier * The smoothness of the endothelium reduces friction between the blood and the vessel wall. * Endothelial cells also play a role in *vasoconstriction* by releasing peptides called endothelins that cause the smooth muscle within the vessel walls to contract. They also * secrete chemicals that inhibit the coagulation of blood, but if the endothelium is damaged, they release different chemicals required for clot formation.
120
electrical circuit in heart
SA generates (P, atrium contr), AV node (PR), bundle of His and bundle branches, Purkinje fibers (QRS and ventricles contr)
121
How to calculate HR on an EKG
count the number of squares between cardiac cycles (P1 to P2) in sex seconds and multiply by 10
122
the walls of all blood vessels contain which three layers, excluding capillaries
tunica intima (endothelial cells, elastic fibers) tunica media (smooth muscle, elastic)) tunica adventitia (outermost)
123
which arteries are elastic
aorta, its major branches tunica media has most of the elastin
124
which arteries are muscular
arteries that branch off elastic arteries. tunica media contains the most smooth muscle cells and least elastic fibers
125
arterioles composition
right before capillaries tunic amedia is very thin but contains ONLY smooth muscle
126
venules composition
Tiny vessels that exit the capillary beds. Thin, porous walls; few muscle cells and elastic fibers right after capillaries
127
veins composition
Thin tunica media and tunica intima, wide lumen, valves prevent backflow of blood
128
blood pressure drops the most at
the arterioles
129
blood pressure is lowest at
the vena cava
130
turbulence versus laminar flow
turbulence occurs when high velocity encounters an obstruction or when the vessels take a sharp turn or narrow suddenly. laminar flow is the steady, streamlined flow of blood that occurs throughout most of the circulatory system.
131
capillaries composition
epithelial cells and basement membrane
132
how does transport work across a continuous capillary
Gases and lipid-soluble substances can cross the endothelial cell membranes by simple diffusion, but ions and large particles often require the help of transport proteins or vesicular transport. Sometimes materials move through intercellular clefts: channels between adjacent endothelial cells.
133
describe fenestrated capillaries
Fenestrated capillaries have pores that increase their permeability and are found in the kidneys and small intestine.
134
describe sinusoid capillaries
Sinusoidal capillaries have a discontinuous endothelium that permits the passage of large particles and even blood cells. They are the most permeable of the capillaries.
135
Plasma and elements are what % | and the contents
55% plasma (albumin, antibodies, proteins, carbs, lipids, salts, waste, gases, hormones) 45% elements (RBC, WBC, platelets)
136
Hematocrit? and percentage for M and F
hematocrit is the percent of RBCs by volume 42 F 46 M
137
how much of the formed elements are WBC and platelets
1%
138
Ratio of platelets to WBC
40 to 1 (platelets 40)
138
where is erythropoietin made
liver and kidneys
139
cell line of erythroblasts
myeloid stem cells, erythroblasts, reticulocytes, erythrocytes | left is immature, right is mature
140
how is RBC reproduction initiated
erythropoietin swims through to the red bone marrow
141
What is the composition of reticulocytes
some ER no nuclei lose the ER after 1-2 days to form mature erythrocytes
142
How long before phagocytes eat old RBCs
120 d or 4 months, located in the spleen, liver, BM
143
composition of hemoglobin
four globin polypeptide chains and heme groups iron in the heme group
144
what is old iron and heme from phagocytized RBCs stored as
ferritin (iron) bilirubin (heme) --> bile excreted
145
Color of basophils
black by basic stains
146
Eosinophils
red by acid stain
147
neutrophils
pale lilac by neutral stains
148
Granulocytes maturation series
myeloid progenator Myeloblast Promyelocyte Myelocyte Metamyelocyte - kidney shaped Band - drum stand shaped Segmented cells (2-5 joined lobes)
149
Mast cells
red/purple toludine blue
149
Monocyte maturation series
Myeloid progenitor Monoblast (12-20 mm) with large oval nucleus and lymphoid dendritic cells Promonocyte (from monoblast) Monocyte Macrophage and myeloid dendritic cell
149
how much of the white blood cells are granulocytes
75%
150
Lymphocyte
Common lymphoid progenitor Lymphoblast (10-20 mm) with large round nucleus Prolymphocyte Small lymphocyte and natural killer cell B and T lymphocytes (from small lymphocyte)
151
Extrinsic clotting mechanism
faster. damaged tissue releases thromboplastin, which triggers a cascade of reactions that results in the production of an enzyme called prothrombin activator
152
Intrinsic pathway clotting mechniasm
When blood encounters a foreign substance or tissue, the Hageman factor (also called coagulation factor XII) is activated, leading to the production of prothrombin activator. From here, the clotting pathways are the same.
153
From prothrombin, both intrinisic and extrinsic cause
Prothrombin activator converts prothrombin to thrombin using calcium as a cofactor. Thrombin splits fibrinogen to form fibrin but also stimulates its own production (a positive feedback loop). Fibrin is a fibrous protein that forms a mesh-like network that traps more platelets and red blood cells. This forms a clot that seals the injured region of the blood vessel.
153
What is heme
heme group consists of a single iron atom surrounded by a complex organic ring called protoporphyrin gives blood its red color
154
hemoglobin structure
four polypeptide chains known as globin (two alpha chains and two beta chains) each chain has a heme group becomes oxyhemoglobin when oxygenated 4 iron atoms for 4 oxygen atoms CO2 can bind but not to iron (carbaminohemoglobin)
154
How is heart rate slowed
The parasympathetic division has the opposite effect. The vagus nerves that innervate the heart release acetylcholine (ACh), which slows the heart rate.
155
What do central and peripheral chemoreceptors monitor in HR
pH, CO2, and O2
155
deglutition
swallowing
155
How is CO2 transported and in what amounts
70% in bicarb 23% in hemoglobin rest is dissolved in the plasma
156
How is BP regulated
baroreceptors in the aortic arch and carotid arteries (both of which detect high blood pressure) and also the venae cavae, pulmonary veins, and atrial walls (all of which detect low blood pressure)
157
What is the process of swallowing both voluntary and involuntary
the voluntary buccal phase and the involuntary pharyngeal and esophageal phases.
158
How many layers does the muscularis external have
three layers, except for the stomach which has two layers
159
How does propulsion work in the GI
radial contraction and then relax to propel in one direction happens during swallowing too from pharynx to esophagus its called peristalsis
160
define segmentation
non adjacent contractions to move food (chyme) back and fourth, and it only happens in the intestines in the HOUSE - houstral contractions in the large intestine to move from ONE HOUSE to the NEXT HOUSE
161
What is mass peristalsis
occur two to four times a day to push large amounts of chyme toward the rectum
162
What spincters are located in the GI
gastroesophageal sphincter, pyloric sphincter, and anal sphincters
163
What enzymes are in the saliva
Amylase (carbs) Lipase (fats) Lysozymes & IgA (bacteria)
164
Other components in saliva
Bicarb Mucin (for gel that coats the bolus)
165
Esophagus wall layers
mucosa, submucosa, muscularis externa, adventitia Muscularis Externa on top 1/3 skeletal in middle mixed on bottom 1/3 smooth muscle
166
GI muscularis externa is made of
smooth muscle
167
Esophageal sphincters
superior and inferior
168
Primary role of the stomach ## Footnote m
mechanical breakdown (3-4h) and storage of food digestions uses unique third muscularis externa layer (oblique) some chemical digestion after food mixed with gastric juice, its called chyme
169
inner surface of stomach
its called mucosa, and forms rugae which allows expansion can hold 1 L typically but up to 4L
170
Four types of cells for secretion in stomach
mucous cells, parietal cells, chief cells, and endocrine cells
171
Endocrine cells
G cells - release gastrin (hormone) into the blood and does not contribute to gastric juices
172
Parietal cells
secrete intrinsic factor, to absorb vitamen B12 in the SI releases HCl (1-3 pH) acidic environment to activate pepsinogen needed by chief cells
173
Chief cells
secrete pepsinogen pepsin is the active form, requires HCl to activate breaks down proteins into peptide chains secrete gastric lipase
174
mucous cells
secrete bicarb esque mucous to protect the lining of stomach from acid
175
Where does most protein and fat digestion take place
SI
176
which spincter is involved in reflux
lower esophageal sphincter or cardioesophageal spincter
177
Fundus
most superior section of stomach
178
Layers of stomach superficial to deep
serosa, muscularis externa (3 layers), mucosa muscularis external outermost is longitudinal, middle is circular, inner is oblique layer
179
Cardiac region of stomach
proximal to esophageal opening, the part of the stomach that food first makes contact with
180
Parts of the pylorus
The pylorus is the inferior part of the stomach proximal to the duodenum. the widest part is the pyloric antrum. the narrowest part is the pyloric canal. pyloric sphincter is the valve
181
The liver has how many lobes
4
182
Bile - | made? function? composed of?
Made in the liver. bile salts made from cholesterol Emulsfying fats into micelles in stimach (fats then further broken down by lipase in SI) composed of bile salts, bilirubin, cholesterol, electrolytes. absorption of ADEK
183
Bile - stored? Triggered?
gallbladder CCK triggered when food enters SI --> bile squeezed into common bile duct + pancreatic duct. then it becomes the hepatopancreatic ampulla of vater and spills into duodenum via duodenal papilla.
184
What happens to ammonia
the liver recognizes it as a toxin. it is a waste product of amino acids. it gets conversted to urea. Urea travels to the kidneys to be excreted.
185
pancreas secretes what
* insulin, glucagon, and somatostatin * digestive enzymes (amylase digests starch, lipase fats) * CCK (acinar cells) to release bile, secretin bicarb (duct cells) to lower pH * proteases in an inactive form (activated at the site of SI) - trypsin, carboxypeptidases A and B, chymotrypsin * Nucleases
186
Brush border enzymes
embedded in microvilli of apical cells in GI (actin filaments that push out the GI to incr SA) | they come from both pancreas and the enzymes in the gut
187
Where does the absorption of water and food take place | for the most part
jejunum and ileum
188
How are amino acids absorbed in the GI
cotransport with sodium into the intestinal cells
189
how are sugars absorbed in the GI
cotransport with sodium into the intestinal cells
190
# 1. how are lipids absorbed in the GI
simple diffusion
191
how is water abosrbed into the GI
simple diffusion
192
how does food absorb overall into the GI and the body
taken into intestinal cells, then diffuse into capillaries within the villi and travel to the liver
193
where does most chemical digestion occur?
SI also where brush border enzymes are
194
how much mechanical digestion takes place in the SI?
Some.
195
name of the glands that secrete bicarb in the SI
Brunners neutralizes acid chyme so that enzymes don't denature
195
Nucleosidase
nucleotide
195
Dextrinase
substrate oligosaccharides
195
Phosphatase
Nucleotide
196
Glucoamylase
substrate oligosaccharide
197
Jejunum | absorpion, digestion?
main site for absorption long villi, dense microvilli
197
How does the large intestine differ anataomically from the SI
It is larger in diameter than the small intestine, but much shorter in length—averaging 1.5 meter There are no villi in the large intestine, but there are pouch-like sacculations called haustra that are separated by folds called plicae semilunares. These pouches are formed by the contraction of smooth muscle within the muscularis layer. The walls of the large intestine are lubricated by mucus, which is secreted by goblet cells.
197
Duodenum - digestion, absorption roles
no absorption, except for iron chemical digestion
197
ileum
longest of the SI, but narrowest Concentration of Peyer's Patches Absorb B12, bile salt, nutrients leftover terminates at the ileocecal valve
198
What does the large intestine absorb, and what is left over
vitamin K, biotin, sodium ions, chloride ions, and water. By the time chyme reaches the large intestine, most of the water (approximately 80%) has already been absorbed by the small intestine. As the chyme is pushed through the colon 90% of the remaining liquid is absorbed, leaving a mass of indigestible food, water, and bacteria.
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Describe the benefits of bacteria in the gut
The bacteria also release vitamin K, biotin, thiamin, riboflavin, and vitamin B12. Vitamin K (required for the synthesis of clotting proteins) and biotin (a cofactor for many enzymes) are absorbed for use in the body. Resident gut flora also help to keep populations of pathogenic bacteria in check. The appendix may serve as a reservoir for beneficial species of bacteria, though it is often infected with harmful microbes.
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where is the appendix
larged in the large intestine, at the cecum
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What spincters are in the anal canal
The anal canal is the last portion of the rectum, and it ends with an involuntary internal sphincter and a voluntary external sphincter.
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Where are feces stored
A dilated region (superior to the anal canal) called the rectal ampulla functions as a storage area for feces before they are eliminated in the process of defecation.
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What is inside of feces
bacteria, water, undigested material, epithelial cells, and bile (which accounts for the brown coloration).
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How do the sphincters work
As this material accumulates, the walls of the rectum expand and stretch receptors send signals that cause the rectal muscles to contract, the internal sphincter to relax, and the external sphincter to contract. At this point, the decision can be made to eliminate or delay elimination.
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Submucosal plexus
embedded in the connective tissue of the submucosa. It functions in regulating local secretions, absorption, contraction of submucosal muscle, and blood flow
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Myenteric Plexus
located between the circular and longitudinal layers of the muscularis externa. This network exerts control over the motility of the GI tract. increases the tone, as well as the rate, intensity, and velocity of contractions.
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If you cut off the brain and spinal cord, would the gut still work?
Yes, it operates independently
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Preganglionic neurons in the parasym and sym nervous system release what
Ach
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what do postganglionic neurons in the symp and parasympath release
sym - norepinephrine parasym - ach
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mechanoreceptors list
* Meissner’s corpuscles, Merkel’s disks, Pacinian corpuscles, and Ruffini endings * muscle spindles that detect stretching of skeletal muscle * receptors of the inner ear that detect vibrations.
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chemoreceptors
olfactory and taste receptors
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Nocicepotrs
detect pain
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exteroceptors
near the body surface transmit information about the external environment.
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proprioceptors
within the inner ear, skeletal muscles, and joints provide information about movement, position, and equilibrium.
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What kind of pathways does the autonomic division use
two neuron pathways
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Interoceptors
of visceral organs and blood vessels provide information about internal stimuli.
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Phasic adaptation
quickly adapt to a constant stimulus, meaning that action potentials decrease over time and eventually stop. This explains the loss of sensation of clothes against the skin, or how an odor seems to disappear when the source is still present. Most tactile and chemoreceptors are phasic.
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Somatic division structure of neurons
All motor neurons of the somatic division run directly from the CNS to the effector without synapsing with another neuron.
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Hypothalamus to pituitary or vice versa?
pituitary is the second stop, or most inferior
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Tonic adapatation
adapt slowly, constantly alerting the CNS of the stimulus with action potentials. Proprioceptors (receptors that provide feedback about position and movement of the body) are tonic receptors, as are photoreceptors (light-detecting receptors) and nociceptors (pain receptors).
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Sensory adaptation
change in sensitivity that occurs when receptors are exposed to a prolonged stimulus. phasic or tonic
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Hindbrain
medulla oblongata, cerebellum, and pons
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Midbrain
integrates sensory signals and orchestrates responses to these signals.
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forebrain
cerebrum, thalamus, and hypothalamus
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cerebral cortex
thin layer of** grey matter** covering the cerebrum. The brain is divided into two hemispheres, with each responsible for multiple functions. The brain is divided into four main lobes, the frontal lobe, the parietal lobe, the occipital lobe, and the temporal lobes.
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parietal lobe
located slightly toward the back of the brain and the top of the head and is responsible for sensory input as well as spatial positioning of the body
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occipital lobe
ocated at the back of the head just above the brain stem. This lobe is responsible for visual input, processing, and output; nerves from the eyes enter directly into this lobe.
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temporal lobe
all auditory input, processing, and output.
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cerebellum
role in the processing and storing of implicit memories. Specifically, for those memories developed during classical conditioning learning techniques and any automatic responses.
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brainstem
midbrain, the pons, and the medulla oblongata are the three parts of the brain stem. respiratory, digestive, and circulatory functions
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Name the cranial nerves 1 through 12
olfactory, optic, oculomotor, trochlear, trigeminal, abducens, facial, vestibulocochlear, glossopharyngeal, vagus, accessory, hypoglossal
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meninges
comprised of the dura mater, arachnoid mater, and pia mater) line the cavity and surround the brain and the spinal cord and contain cerebrospinal fluid between the arachnoid mater and pia mater in the subarachnoid space. The meninges and cerebrospinal fluid protect and cushion the dorsal cavity.
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Which cranial nerves are both sensory and motor
Trigeminal, facial, glossopharyngeal, vagus
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cranial cavity
contains the brain, the 12 cranial nerves, and the pituitary gland.
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which cranial nerves are only motor
oculomotor, trochlear, abducens, accessory, hypoglossal
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CN adjusts pupil and lens of eye
oculomotor 3
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chewing
trigeminal, 5
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facial sensation
trigeminal
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facial expression
facial, 7
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taste other than ant 2/3 of tongue
glossopharyngeal
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anterior two/thirds of tongue
facial
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swallowing
glossopharyngeal (9), hypoglossal (12) and accessory (11), 10
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saliva CN
glossopharyngeal
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control of peripheral nervous system
vagus (10)
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tongue motor, speech
hypoglossal, 12
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sight
optic, 2
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movement of the head and neck
accessory
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smell
olfactory, 1
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what encloses the vertebral cavity
meninges
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spinal cord composition
exterior layer of white matter that surrounds an interior core of grey matter
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# [](http://)[](http://)[](http://)[](http://)[](http://)[](http://)[](htt vertebral cavity contains
vertebrae and spinal cord
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grey matter in spinal cord
Grey matter consists mostly of interneurons, but also contains motor neurons and glial cells. (The axons are mostly unmyelinated, giving the tissue its grey appearance.) The cell bodies of afferent neurons reside in dorsal root ganglia, just outside the spinal cord.
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white matter in spinal cord
glial cells and myelinated bundles of axons that form tracts to and from the brain. * There are no cell bodies or dendrites in white matter.
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afferent vs efferent nerve fiber pathways
Afferent fibers enter into the posterior/dorsal aspect of the spinal cord (a region called the posterior grey horn) through the anterior root, while efferent fibers exit on the anterior/ventral aspect (the anterior grey horn) through the posterior root.
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unique organelle to neurons
Granular Nissl bodies (made of rough ER and clusters of free ribosomes) synthesize proteins for use within the cell.
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spinal cord anatomy: | which side is the ganglia on? what does that side look like?
the tail of the butterfly is the posterior side w/ the dorsal root ganglion on that side. the grey is on the inside, white is on the outside. the ends are called 'horns'.the white area superficial to it is the funiculus. anterior median sulcus is the crack in the front. posterior median sulcus is the buttcrack.
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polysynaptic reflex
brain can override reflex interneurons
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monosynaptic reflex.
don't involve the brain can't stop the reflex from happening direct connection between sensory and motor
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the posterior pituitary houses what
The hypothalamus produces oxytocin and antidiuretic hormone (ADH), but these hormones are stored in and secreted by the posterior pituitary.
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schwann cell
myelin sheath of peripheral neurons they are a type of glial cells that form lipid rich layers the nucleus and cytoplasm is outside of the sheath Think won the race and you have to use arms and legs to win a race
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part of a cell that is absent in neurons
centrioles in mature neurons. they can't divide
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what type of neurons are unipolar
sensory
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what type of neurons are pseudounipolar
sensory
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where are bipolar neurons
retina and inner ear
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what neurons are multipolar
motor and interneurons
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where does the axon emerge
axon hillock
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what is the cytoplasm of the axon called
axoplasm
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what does the axoplasm lack
golgi, nissl, and ribosomes protein translation
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what are collaterals
axon splits and it allows neurons to interact with multple other cells
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non-myelinating schwann cells
when the axons are super skinny
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neurilemmal sheath
in the outer neurilemmal sheath of a schwann cell is where the nucleus and cytoplasm are. (neurons)
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what is responsible for mylein sheath of CNS
oligodendrocytes Think oligarch is the head. Oligarchs are OP they can work with multiple neurons.
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what is different about oligodendrocytes
they can myelinate tons of axons
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conditions from damaged myelin
MS leukodystrophies
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white or grey matter in the CNS
mostly white in the CNS white in the CNS is myelinated grey matter is unmylinated
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Nodes of Ranvier
uninsulated gaps between myelinated portions of the axon
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downsides of myelinated axons
less neuroplasticity
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can glial cells divide?
yes | nearly all brain tumors come from them
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are there more glial cells or neurons?
glial cells
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glial cells in PNS
schwann, satellite
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glial cells in CNS
astro,micro,oligo, ependy
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astrocytes
* most abundant * anchor * helps exchange of meterials between capillaries and neurons * uptake of excess ions
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microglia
few extensions phagocytes - dead debris and immune
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oligodendrocytes
extensions wrap around axons of CNS neurons mylein sheath
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ependyma
epithelial lining of ventricles central canal of spinal cord CSF circulate between brain and spinal cord
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Schwann cells
produce myelin sheath that insulate PNS
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Synapse that is axodendritic
terminate on the dendrite of a postsynaptic neuron
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axosomatic
terminates on a POSTsynaptic soma
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axoaxonic
synapse that is rare. terminates on a POSTsynaptic axon.
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most synapses are what kind of junction
chemical unidirectional and they use neurotransmitters
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what is unique about electrical synapses
the bidirectional electrical synaptic junctions do not use neurotransmitters. they are linked only by gap junctions that allow the flow of ions between cells. -electrical synapses are rare, faster, always excitatory
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ach does what
stim skeletal muscle
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# [](http://)[](http://)[](http://)[](http://)[](http://)[](http://)[](htt NE does what
mood and sleep
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dopamine
mood, attention, reward, and movement
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histamine
promotes wakefulness in the hypothalamus
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serotonin
mostly inhibitory. sleep, mood, hunger, arousal
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GABA
inhibitory NT
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Glutamate
excitory NT
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what organs are under the control of the somatic (voluntary) nervous system
posture, eye movements
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# [](http://)[](http://)[](http://)[](http://)[](http://)[](http://)[](htt skeletal muscle pump vs thoracic pump
sk msk - large peripheral veins have valves that prevent backflow, and skeletal muscle pump forward thoracic- During inspiration, contraction of the diaphragm and intercostal muscles expands the thoracic cavity. The increased volume results in a decrease in pressure, which is transmitted to the right atrium. This drop in pressure helps the blood to return to the heart. when the pressure in the thoracic cavity decreases, the pressure in the abdominal cavity increases, squeezing the blood in the inferior vena cava toward the heart.
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where do thermoreceptors send info
POSTERIOR hypothalamus
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is shivering endothermic or exothermic
exothermic reaction releases energy in the form of heat to warm the body
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features of a skeletal muscle cell
These muscles are striated; the muscle fibers have alternating regions of light and dark bands. A single skeletal myocyte is cylinder- shaped and has many nuclei.
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features of a smooth muscle cell
. Smooth muscle tissue is found in the walls of hollow organs and vessels and aids in the movement of substances such as food and blood. The cells are spindle-shaped, non-striated, and uninucleate.
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cardiac muscle cell features
exhibits myogenic activity. Cardiac muscle tissue is found in the walls of the heart and is required for the pumping of blood. The cells are branched, striated, and usually uninucleate (but may have two nuclei). They are connected to each other by intercalated discs with gap junctions that allow the cells to communicate.
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T tubules
tunnel-like invaginations of the sarcolemma, the plasma membrane of striated muscle cells
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what role do T tubules play in muscles
When an action potential propagates along the sarcolemma, the T-tubules help to depolarize the cell by carrying the impulse to the sarcoplasmic reticulum (SR)
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what is the sarcoplasmic reticulum
sarcoplasmic reticulum (SR) surrounds the myofibrils in a muscle cell. The SR is a form of smooth endoplasmic reticulum that is specialized to store and release calcium ions.
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t tubules
t-tubules are sandwiched between two enlarged chambers of the SR called terminal cisternae. extension of the sarcolemma
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how does a muscle relax at the SR
ATP powered calcium pumps in the SR membrane pump calcium back into the SR to relax the muscle
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what is a sarcomere
The structure of the contractile apparatus is similar among striated muscle tissues and consists of a repeating unit
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contractile apparatus
a unit within muscle tissue that is specialized for contraction
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what makes up a myofibril
Tens of thousands of these sarcomeres lie end to end to form a myofibril.
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what is a z line
boundary that seperates sarcomeres -point of anchorage for actin thin filaments.
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do actin change length during muscle contraction
The filaments themselves do not change length during contraction their arrangement allows them to slide over each other when myosin heads pull on the thin filaments, causing the sarcomeres to shorten and the muscle to contract.
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# [](http://) how many filaments surround a thick myosin filament
6
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does smooth muscle contain sarcomeres
while smooth muscle cells do contain actin and myosin, the filaments are disorganized, and no sarcomeres are present.
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what is SO type 1
muscle fibers slow twitch oxidative
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What type of muscle fibers do most muscles have
a blend of fast (II) and slow twitch (I)
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maintaining posture uses what type of muscle fibers
type 1, slow twitch
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between 3 types of muscle fibers, explain use
1 = low intensity aerobic, or posture 2a= running 2b= short bursts of sprinting or heavy lifting
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of three muscle fibers, give diameter
slow 1 = smallest fast 2a = intermediate fast 3 a= largest
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between three types of muscle fiber, explain conc. of mitochondria
1 = high 2a = moderate 2b = low
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between the three muscle fibers, explain myoglobin
myoglobin binds oxygen. type 1 is for aerobic capacity, so it has the most myoglobin. myoglobin gives it a red color. type 2a is for anaerobic and aerobic. middle amount of myoglobin. pink color. 2b is anaerobic. least amount of myoglobin. white color.
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between the three muscle fiber types, what is contractile velocity versus force production
type 1 = force production low, and slow velocity type 2a= moderate force production, rapid velocity type 2b= high force production, rapid velocity
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capillary density of three muscle fiber types
high density type 1 mod density type 2a low density type 2b
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direction of current through the heart
SA, AV, bundle of his, his branches, perkinje fibers
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how does an AP flow in the heart
As the impulse travels through the sarcolemma of a cardiac muscle cell, voltage- gated calcium ion channels open, allowing the entry of extracellular Ca2+ The inflow of Ca2+ triggers the release of even more Ca2+ from the sarcoplasmic reticulum. | cardiac cells have a prolonged AP compared to skeletal
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# [](http://) what increases HR and decreases HR 5 items total
Sympathetic stimulation increases heart rate, while parasympathetic stimulation (the vagus nerve) decreases heart rate. The endocrine system influences heart rate as well. Epinephrine secreted from the adrenal medulla and thyroxine from the thyroid gland both increase heart rate.
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# [](http://)[](http://)[](http://)[](http://)[](http://)[](http://)[](htt what is oxygen debt
is the amount of oxygen required to restore metabolic conditions to resting levels. The amount of oxygen required to accomplish exercise, and to replenish the levels of ATP and creatine phosphate, is called oxygen debt.
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# [](http://)[](http://) explain the use of atp during rest and not at rest
Muscle activity is powered by the hydrolysis of ATP. In a resting state, aerobic respiration provides enough ATP for muscles to function. Stored ATP is quickly used up during intense exercise, and a molecule called creatine phosphate phosphorylates ADP to produce ATP
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explain anaerobic respiration during exercise
Anaerobic respiration also supplies ATP relatively quickly, but only for a short amount of time. If oxygen is available, aerobic respiration synthesizes ATP. When oxygen levels become depleted, lactic acid (a byproduct of anaerobic respiration) begins to accumulate.
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explain lactic acid buildup
The buildup of lactic acid, along with the depletion of ATP and oxygen, causes muscle fatigue. Lactic acid that does not remain in the muscles is brought to the liver, where it is converted into glucose. The amount of oxygen required to accomplish this task, and to replenish the levels of ATP and creatine phosphate, is called oxygen debt.
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autonomic nervous system - is the preganglion neuron bigger or post ganglion bigger
Postganglionic nerve fibers are shorter than presynaptic fibers, and they extend to the effectors
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autonomic nervous sustem - what NT sympathetic and NT parasympathetic
Preganglionic neurons of both the sympathetic and parasympathetic systems release acetylcholine (ACh)
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what do post gnaglion of autonomic nervous system release
Ach for parasympathetic, and NE for sympathetic
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# [](http://)[](http://)[](http://)[](http://) sympathetic nervous system effects
The sympathetic division induces a fight or flight response, which causes heart rate and blood pressure to increase, and blood to be diverted away from the digestive system.
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parasympathetic nervous system effects
The parasympathetic division induces a rest and digest response, which causes heart rate and blood pressure to decrease, and promotes digestion.
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what part of the brain is responsible for voluntary movements
motor cortex initiates
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what is the lower part of the brain stem responsible for
The lower part of the brainstem called the medulla oblongata sends signals to involuntary muscles that play a role in digestion, vasodilation/vasoconstriction, heart rate, respiratory rate, and other visceral functions.
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# [](http://)[](http://)[](http://)[](http://)[](http://)[](http://)[](htt where does the stimulus for skeletal muscle contraction come from
motor neurons communicated through the NMJ (neuromuscular junction)
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can a single motor neuron form synapses with multiple muscule cells or just one?
A single motor neuron can form synapses with multiple muscle cells The neuron and the muscle cells that it innervates are collectively called a **motor unit**.This arrangement allows a large group of cells to contract together.
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what is a motor pool
All the motor neurons that innervate the same muscle make up a motor pool
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define epedidymis
The epididymis is a convoluted tube attached to the outside of a testicle that nourishes sperm as they finish maturing, and stores them until ejaculation
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# [](http://)[](http://)[](http://)[](http://)[](http://)[](http://)[](htt explain NMJ
When an action potential reaches an axon terminal, voltage-gated calcium ions in the membrane are opened, and Ca2+ enters. These ions bind to synaptic vesicles that store acetylcholine (ACh), causing them to fuse with the membrane and release ACh into the synaptic cleft. ACh binds to nicotinic receptors on a folded portion of the sarcolemma known as the motor end plate. The permeability of the muscle cell changes, and the cell depolarizes. The action potential is taken into the muscle cell via T-tubules, causing calcium channels in the sarcoplasmic reticulum to open. The release of calcium into the sarcoplasm causes the muscle to contract. | see page 144
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Do women produce oocytes as they go, or before birth?
The ovaries produce much higher levels of estrogen than male gonads. They contain all of the oocytes that they will ever have before birth, and only one is released per month during ovulation.
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# [](http://)[](http://)[](http://)[](http://)[](http://)[](http://)[](htt what is vas deferens
sperm duct from epididymis | heads to the ejaculatory duct then urethra
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define seminal vesicles and components of what they produce
secrete fluid into the ejaculatory duct that makes up roughly 60% of the volume of semen. The contents of this mildly alkaline fluid include fructose, prostaglandins, and proteins
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# [](http://)[](http://)[](http://)[](http://)[](http://)[](http://)[](htt define prostate gland
Secretions of the prostate gland (about 30% of semen volume) nourish the sperm and increase their motility.
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Cowper's glands
lubrication 2-5% of semen volume
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describe the spongy tissue in the penis
a pair of corpora cavernosa and the corpus spongiosum that surrounds the urethra a cavern is created by two walls or two corpora cavernosa
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define scrotum
the sac that protects the sperm-producing testes and keeps them at the proper temperature
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describe ovulation and fertilization
ovaries produce oocytes, and also secrete sex hormones. When an oocyte is released during ovulation, it is “captured” by the fallopian tube, also known as the uterine tube or oviduct, which is not directly connected to the ovaries. Fertilization typically occurs in the fallopian tube, and implantation of the fertilized egg usually occurs in the endometrium of the uterus.
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describe tunica albuginea and its compartments
fibrous layer of connective tissue surrounding the testes.Thin layers of tissue extend from the tunica albuginea and divide the testes into 250 to 300 compartments called lobules. Each lobule contains one to four seminiferous tubules, the sites of spermatogenesis
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# [](http://)[](http://)[](http://)[](http://)[](http://)[](http://)[](htt define bartholins glands
Bartholin’s glands produce a fluid that lubricates the vagina
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how are ovaries held in position
peritoneal ligaments
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# [](http://)[](http://)[](http://)[](http://) describe the different cell types in the tunica albuginea
epithelial lining of these tubules consists of the spermatogenic cells that give rise to sperm, as well as the cells that nourish them (sustentacular cells, also called **Sertoli** cells). Interstitial cells (**Leydig** cells) around the seminiferous tubules produce testosterone, which stimulates the production of sperm.
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describe the structure of seminiferous tubules
The seminiferous tubules join together to form a network of channels called the **rete testis**. Rete Testis bring maturing sperm cells to the efferent ducts where they exit the testes and enter the epididymis
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layers of tissue on ovary also the sections of the ovary
germinal epithelium (cuboidal, simple), superior tuniva albuginea (inferior) cortex and medulla
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# [](http://) describe the cortex of the ovary
granular appearance due to the presence of thousands of nourishing follicles in various stages of development. Each of these saclike follicles contains an oocyte.
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oocyte development
Initially, the oocyte is surrounded by a single layer of follicular cells, but as the follicle matures, the cells give rise to a multi-layer of estrogen-producing granulosa cells. After ovulation, a gland called the corpus luteum forms, and it secretes progesterone and small amounts of estrogen. This gland disappears unless pregnancy occurs. | happens in the cortex of the ovary
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describe the medulla of the ovary
The interior of the ovary, or medulla, is made of loose areolar connective tissue, and contains many blood vessels, lymphatic vessels, and nerves that enter and leave through the hilum.
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what are wolfian ducts and mullerian ducts
Wolffian ducts give rise to male internal reproductive structures, and Mullerian ducts give rise to female internal reproductive structures. As one system develops, the other is broken down. ## Footnote women go to the mall, men are wolves
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# [](http://)[](http://)[](http://)[](http://)[](http://)[](http://)[](htt what gene on chromosomes is responsible for male organs and repression of female organs?
SRY
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when do the genitalia become evident
7 weeks after conception
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# [](http://)[](http://)[](http://)[](http://)[](http://)[](http://)[](htt describe what happens in the brain during puberty
. At puberty, there is a surge in development as the hypothalamus releases gonadotropin releasing hormone (GnRH). This triggers the secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the **anterior** pituitary gland.These gonadotropins increase the production of sex hormones, which allow the male and female reproductive organs to mature.
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what happens to the body during puberty
Spermatogenesis begins in males, and ovulation and menstruation begin in females. Secondary sex characteristics emerge as well. Males develop facial, axillary, and pubic hair, and the voice deepens as the larynx grows. Females develop pubic hair, begin to ovulate and menstruate, and develop wider hips.
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# [](http://)[](http://)[](http://)[](http://) three phases of womens reproductive cycle
follicular phase, ovulation, luteal phase
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follicular phase of womens repro cycle
During the follicular phase, FSH stimulates the maturation of the follicle, which then secretes estrogen. Estrogen helps to regenerate the uterine lining that was shed during menstruation.
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ovulation
Ovulation, the release of a secondary oocyte from the ovary, is induced by a surge in LH.
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luteal phase
The luteal phase begins with the formation of the corpus luteum from the remnants of the follicle. The corpus luteum secretes progesterone and estrogen, which inhibit FSH and LH. Progesterone also maintains the thickness of the endometrium. Without the implantation of a fertilized egg, the corpus luteum begins to regress, and the levels of estrogen and progesterone drop. FSH and LH are no longer inhibited, and the cycle renews.
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three phases of the uterine cycle
the proliferative phase, secretory phase, and menstrual phase.
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# [](http://)[](http://)[](http://)[](http://)[](http://)[](http://)[](htt proliferative phase
regeneration of the uterine lining
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secretory phase
endometrium becomes increasingly vascular, and nutrients are secreted to prepare for implantation
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menstrual phase
Without implantation, the endometrium is shed during menstruation.
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describe pregnancy from beginning to end
Pregnancy: When a **blastocyst** implants in the uterine lining, it **releases hCG.** This hormone prevents the corpus luteum from degrading, and it continues to produce estrogen and progesterone. These hormones are necessary to maintain the uterine lining. By the second trimester, the **placenta secretes enough of its own estrogen and progesterone** to sustain pregnancy. The levels of estrogen continue to increase throughout pregnancy, while progesterone decreases.
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Describe the process of parturition ## Footnote giving birth
first, **increased levels of fetal glucocorticoids**, which act on the placenta to **increase estrogen and decrease progesterone. ** second, **stretching of the cervix** stimulates the release of oxytocin from the posterior pituitary gland. Oxytocin and estrogen stimulate the release of prostaglandins, and **prostaglandins and oxytocin increase uterine contractions**. This positive feedback mechanism results in the birth of the fetus.
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describe the process of lactation
During pregnancy, levels of the hormone **prolactin increase**, but its effect on the **mammary glands** is inhibited by estrogen and progesterone. After parturition, the levels of these hormones decrease, and prolactin is able to stimulate the production of milk. Suckling stimulates the release of oxytocin, which results in the ejection of milk.
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5 layers of epidermis superficial to deep
stratum corneum, lucium, granulosum, spinosum, basale dont forget basement membrane
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what cells are in stratum basale
keratinocytes. they are the stem cells. cells differentiate more towards the surface. usually contains just a single layer of cuboidal or columnar cells that adhere to the basement membrane. These are the most nourished cells because they are closest to the capillaries of the dermis.
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stratum spinosum
8-10 layers of spiny cells connected by desmosomes There is limited mitotic activity in the deeper portion of this layer.
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straum granulosum
The stratum granulosum consists of two to five layers of slightly flattened cells containing granules of keratohyalin. The cells in the superficial portion of this layer lose their nuclei.
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stratum lucidum
The stratum lucidum consists of two to five layers of dead, flattened keratinocytes and is only present in the palms and the soles of feet. These cells contain eleidin, a translucent, water-resistant protein derived from keratohyalin.
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stratum corneum
most superficial layer, and it consists of 15 to 30 layers of dead, keratin-containing squamous cells. This layer helps to prevent water loss from the body.
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keratinocytes
MC epidermis cell type. arise from stratum basale. they flatten and die as they move superiorly. produce keratin, which hardens the cell to create water resistance.
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melanocytes
produce melanin, a pigment that gives skin its color and protects against UV radiation.
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merkel cells
cutaneous receptors detect light touch. located in stratum basale. markers must use light touch or you get ugly marker blobs
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fibroblasts
secrete collagen, elastin, ECM
370
skin absorbs what
using eccrine glands, reabsorb sodium ions before losing it through perspiration
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langerhans cells
antigen presenting cells of the immune system (phagocytes). MC stratum spinosum
370
adipocytes
fat cells
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mast cells
antigen presenting cells play a role in the inflammatory response produce histamine
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skin excretes what
urea and ammonia through sweat
371
function of hypodermis
anchor skin to underlying organs
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macrophages
phagocytitc cells engulf pathogens
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1st line of defense vs 2nd line of defense against environment
1st line is the skin 2nd line is macrophages and immune system
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where are the arrector pilli
smooth type muscle in the dermis
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sweat glands 2 types
eccrine and apocrine
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apocrine
lies deeper in the dermis and empty onto hair follicles play NO role in thermoregulation (Apocrine is Aimless) activate at onset of puberty in response to sex hormones found only in certain places of the body
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hypodermis consists of
loose connective tissue esp. adipose to protect from heat and cold
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subcutaneous tissue aka
hypodermis considered seperate from skin
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how is heat lost from capillaries
radiation primarily. conduction and convection can also cool the body, assuming temp in environment is c ooler
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how does body warm up via vasoconstrict
adrenal medulla releases NOR and EPI which causes vasoconstrict
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eccrine
lies more superficial in the dermis, and drumps onto the skin directly. found everywhere help in thermoregulation release of sweat regulated by the hypothalamus men>women
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What are nails
dense plates of hardened keratinocytes that protect the distal ends of fingers and toes grows from nail matrix
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response of body to mechanical abraison
the stratum basale responds by increasing the rate of mitosis, which soon leads to an overdevelopment of the stratum corneum (hyperkeratosis). The buildup of dead cells forms a protective pad called a callus.
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what sensory receptors do nails have
pressure, but nothing else
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what happens to skin during mechanical abrasion
protected by keratin filled celled of epidermis but cells in stratum corneum are sloughed off. in place of the sloughed off cells, keratinocytes and glycolipids glue together to form a seal.
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Hair function
shield from UV, cushioning, insulation trap foreign particles sensory receptors in response to injury
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how does the skin prevent microorganisms preventatively
"acid mantle" secretions of sweat and sebacious glands mix together to form low pH & enzymes to help prevent infections also the good bacteria living on the surface can outcompete the bad bacteria deep in the layers of the skin are dendritic cells to phagocytize
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does the endocrine system have specificity
Only cells with receptors that are specific to the secreted hormones are affected. This specificity allows hormones to control targeted tissues and organs, often other endocrine glands (these are called tropic hormones).
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organs with endocrine function
hypothalamus, pineal gland, pituitary gland, thyroid, parathyroid glands, thymus, adrenal glands, gonads, and pancreas. Certain cells within the heart, kidneys, gastrointestinal tract, and placenta also have endocrine functions.
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GnRH does what
stimulates anterior pituitary to release LH and FSH
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exocrine glands
exocrine glands release non- hormone products such as sweat, oil, tears, and bile through ducts to their target locations—usually a cavity or epithelial surface inside or outside the body. Unlike hormones, exocrine products do not bind to receptors.
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define hypothalamus
the link between the nervous system and the endocrine system. It is located in the brain, **superior** to the pituitary and inferior to the thalamus. The hypothalamus communicates with the pituitary by secreting “releasing hormones” (RH) and “inhibiting hormones” (IH)
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define hormones
Hormones are molecules that bind to receptors and deliver regulatory messages. Many of these signaling molecules are steroids derived from cholesterol. These include the sex hormones and corticosteroids. The rest are non-steroids and include amines, peptides, and proteins.
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TRH does what
thyrotropin releasing hormone stimulates TSH
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intermediate pituitary
melanocyte
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posterior pituitary gland produces
release oxytocin where its also stored, vasopressin, ADH (stored) | prolactin is produced in anterior pituitary, not posterior oxytocin squi
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pituitary
“master gland” located within the sella turcica of the sphenoid bone, beneath the hypothalamus. This pea-sized gland hangs from a thin stalk called the infundibulum, and it consists of an anterior and posterior lobe, each with a different function.
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what does LH do
Targets the gonads—stimulates the production of sex hormones; surge stimulates ovulation in females
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what does FSH do
Targets the gonads—stimulates the maturation of sperm cells and ovarian follicles
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define pineal gland
situated between the two hemisepheres of the brain where the two halves of the thalamus join secretes melatonin
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thyroid gland
attachment between the two lobes is called the **isthmus**. The isthmus is on the anterior portion of the trachea, with the lobes wrapping partially around the trachea
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T3
triiodothyronine cell metabolism
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calcitonin
lowers blood calcium
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T4
thyroxine cell metabolism
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Thymus gland location and function
Located between the sternum and the heart, embedded in the mediastinum. It slowly decreases in size after puberty. releases Thymosin; Targets lymphatic tissues— stimulates the production of T- cells
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parathyroid gland does what
targets bone and kidney - raises blood calcium
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location pancreas anatomy
The head of the pancreas is situated in the curve of the duodenum and the tail points toward the left side of the body. The pancreas is mostly posterior to the stomach.
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insulin definition
Targets the liver, muscle, and adipose tissue—decreases blood glucose
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GHIH
GHIH - somatostatin. inhibits secretion of insulin and glucagon
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Gastrin
Targets the stomach—stimulates the release of HCl
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glucagon
targets the liver - increases blood glucose
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adrenal medulla
inner part of the gland targets blood vessels, liver, and lungs—increase heart rate, increase blood sugar (fight or flight response)
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Secretin
Targets the pancreas and liver— stimulates the release of digestive enzymes and bile
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Calcitrol
Targets the intestines—increases the reabsorption of Ca2+ released by the kidneys
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CCK—cholecystokinin
Targets the pancreas and liver— stimulates the release of digestive enzymes and bile
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adipose tissue releases what
Targets the brain—suppresses appetite
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ANP
atrial natriretic peptide; Targets the kidneys and adrenal cortex— reduces reabsorption of Na+, lowers blood pressure
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ovaries produce
estrogen, progesterone, inhibin
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Inhibin
targets anterior pituitary inhibits the release of FSH
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what does progesterone do
Targets mainly the uterus and mammary glands—stimulates uterine lining growth, regulates menstrual cycle, required for maintenance of pregnancy
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Placenta responds to which hormones
Estrogen, progesterone, inhibin and hCG
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what does estrogen do
Targets the uterus, ovaries, mammary glands, brain, and other tissues—stimulates uterine lining growth, regulates menstrual cycle, facilitates the development of secondary sex characteristics
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hCG action
Targets the ovaries—stimulates the production of estrogen and progesterone
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Testes produce what and what does it do
Targets the testes and many other tissues— promotes spermatogenesis, secondary sex characteristics testosterone inhibit targets anterior pituitary, inhibin
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describe hormones classification
Hormones can be broadly classified into lipid-soluble hormones (steroids) and water-soluble hormones (non-steroids).
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Steroid hormones characteristics
* Steroid hormones are derived from cholesterol, and their base structure consists of four fused carbon rings. * They are released by the adrenal cortex, testes, ovaries, and the placenta. * Major types of steroid hormones include the sex hormones (estrogens, androgens, progesterone) and the corticosteroids (glucocorticoids and mineralocorticoids). * Since these * hormones are lipid-soluble, they can diffuse through the cell membrane and bind to the nuclear receptors that regulate transcription.
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non steroid hormone characteristics
Non-steroid hormones tend to elicit faster responses than steroid hormones. They cannot diffuse into the cell and instead bind to receptors on the cell membrane, activating second-messenger systems. classified into amines, peptides, and proteins.
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amines
Amines are derivatives of the amino acids tyrosine or tryptophan, and include epinephrine, norepinephrine, thyroxine, and melatonin.
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peptide hormones
Peptide hormones are short chains of amino acids. Common examples include oxytocin, somatostatin, and antidiuretic hormone.
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protein hormones
Protein hormones such as insulin, growth hormone, and parathyroid hormone consist of longer chains—generally over 100 amino acids.
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glycoprotein hormones
Hormones can also be glycoproteins. Follicle-stimulating hormone, thyroid-stimulating hormone, and luteinizing hormone all have carbohydrate attachments. FSH TSH LH
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layers of connective tissue surrounding the kidney
renal fascia, the adipose capsule, and the innermost renal capsul
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where is the renal capsule
most inferior surrounds the renal cortex
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where are majority of nephrons housed
renal cortex tubules dip into the medulla
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ultrafiltration
what happens in the renal cortex nonspecific filtration of blood under high pressure. It is also responsible for the majority of the reabsorption of water.
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# [](http://)[](http://)[](http://)[](http://)[](http://)[](http://)[](htt what does the renal hilum contain
BV and nerves
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glomerulus
ball of capillaries inbetween the renal artery and vein
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what parts of nephron are inside the cortex
renal corpuscles, convuluted tubules cortical labryrinth
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what part of the nephron is inside of the renal medulla
loop of henle
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medullary rays
The thick, straight portions of the proximal and distal tubules, as well as the collecting ducts
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how does urine get from the medulla to the pelvis
it passes through a renal papilla at the apex of the upside down pyramid, then it moves through calyces (ducts) to the renal pelvis.
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Renal corpuscle
filters the blood. has bowwman's capsule wrapped around a glomerulus. | glomerulus is the tangled clump of capillaries
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what portion of nephrons are long and what are short
About **85%** of nephrons (cortical nephrons) have short loops of Henle that extend **only slightly into the medulla**. The remaining **15%** (juxtamedullary nephrons) have **longer** loops that extend deeper.
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is the collecting duct inside of the nephron
no! the nephron is considered seperate.
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renal tubule
collects and concentrates filtrate continuous with bowman's capsule. diff regions that differ in structure and function
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describe the capillaries in the glomerulus
fenestrated capillariesare lined with a thin layer of epithelial cells
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what are mesangial cells
Mesangial cells contract to regulate blood flow, and also support the capillary network.
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How does material move from bowmans capsule into the capillaries
Gaps between the pedicels (filtration slits) allow the passage of tiny molecules and ions.
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what makes up the filtration membrane
the endothelial cells of the capillaries, the basement membrane, and the pedicels
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cells & function from the PCT
The proximal convoluted tubule extends from Bowman’s capsule, and this coiled tube is characterized by cuboidal cells with dense microvilli that aid in reabsorption and secretion. There are only sparse microvilli in the rest of the tubule.
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is there high or low solute concentration in the medulla
high, and it helps reabsorb water (loop of henle)
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Bowman's capsule structure
outer layer of epithelial cells that form the parietal layer, and it has a visceral layer of podocytes with processes called pedicels that wrap around the capillaries.
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what is the bowman's space
the cavity between the two layers of bowman's capsule fluid from the blood leaves the fenestrated capillaries and passes through the filtration membrane and collects in Bowman’s space the final place fluid goes before entering the renal tubule
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describe the ascending limb in the loop of henle
The ascending limb widens into a thick portion composed of larger epithelial cells. The loop is lined with simple squamous epithelial cells, with the exception of the thick ascending limb which is lined with simple cuboidal cells.
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explain what is absorbed where in the loop of henle
1. descending limb (which reabsorbs **water**) that plunges into the medulla, a U-turn that curves back toward the cortex, 2. ascending limb (which reabsorbs **ions**)
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DCT
cuboidal cells, which is involved in absorption and secretion, but not to the extent of the proximal convoluted tubule. It is also shorter in length.
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collecting duct shape
The collecting duct is the final site of reabsorption in the kidney, and it is shared by multiple nephrons The distal tubule empties filtrate into the collecting TUBULE, which merges with other collecting tubules to form the collecting DUCT
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collecting tubule cell types
1. Collecting tubules are lined with simple cuboidal epithelium, but these cells elongate to form columnar cells as they get closer to the duct. 2. Some of these cells are principal cells, which reabsorb sodium ions and water (under ADH and aldosterone control). 3. Other cells are intercalated cells, and they play an important role in acid-base balance and the reabsorption of sodium ions. Both these types of cells can also be found toward the end part of the distal tubule, but there are fewer microvilli than in the collecting duct.
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where does filtrate go after the collecting duct
The filtrate that passes through the collecting duct enters the minor calyces at the apex of a medullary pyramid.
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describe hydrostatic pressure of blood in glomerulus
nonspecific filtration is driven by the hydrostatic pressure of the blood. This pressure is higher than in other capillaries because the efferent arterioles that exit the glomerulus have a smaller diameter than the afferent arterioles that enter.
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what can pass through the fenetrated capillaries in the glomerulus
Water and small solutes from the blood are forced through fenestrations in the capillaries, leaving behind larger in the filtrate
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how are solutes moved in the nephron
primary active transport, secondary active transport, or diffusion, and water is reabsorbed by osmosis.
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what is the 3 layered filtration membrane
The first layer is the endothelial lining of the capillaries. Fenestrations in the capillaries prevent the passage of blood cells. The second layer is the basement membrane, which excludes plasma proteins such as albumin. The third layer is the visceral lining of Bowman’s capsule. Small filtration slits between the podocytes allow only the smallest of particles to pass.
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in the glomerulus, what is the same?
The concentration of a solute in the glomerular **filtrate** is the same as the concentration in the **blood**. on average, about 1/5 of the blood is filtered, but this varies depending on the pressure.
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Secretion/reabsorption for PCT
1. secretion: for H+, creatinine, NH4, drugs, toxins, all active transport! 2. reabsorption: 60-70% of the volume of all filtrate. glucose, aa, vitamins, Na, cl, k, ca, mg, hco, phosphate, water, urea
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secretion/reabsorb in descending limb loop of henle
secretion: urea reabsorption: water
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DCT secretion/reabsorb
secretion: K, H reabsorb: Cl, Ca, Na, Water (no mg, no k) but water is variable permeability; depends on aldosterone
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collecting duct reabsorb/secrete
secretion: K, H reabsorb: urea, bicarb, na, water water is variable and depends on aldosterone and ADH
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loop of henle ascending secret/reabsorb
secretes none reabsorption: na, cl, k mg, ca (not water)
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describe the countercurrent mechanism ## Footnote memorize paragraph
the use of active transport to move solutes out of the ascending loop of Henle (which is impermeable to water) into the medullary interstitium. The osmotic gradient that is created causes water to diffuse out of the descending limb (which is permeable to water), concentrating the filtrate. The recycling of urea also helps to maintain a high medullary osmolarity. The descending loop of Henle and the collecting duct are both permeable to urea, but the descending limb and the distal tubule are not. Urea enters the descending loop from the interstitium, and travels through the renal tubule to the collecting duct, where it reenters the interstitium.
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does urine become less or more concentrated after aldosterone is increased
urine becoems more concentrated because water goes into the blood instead of the urine
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what actions move urine from the kidney to the bladder
peristalsis and gravity
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what parts of the urinary system are lined with transitional epithelium
ureters, bladder, and sup. portion of the urethra it allows expansion
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countercurrent multiplier vs countercurrent exchanger
1. countercurrent multiplier: occurs in the loop of henle- creating osmotic gradient in medulla to reabsorb water. 2. countercurrent exchange: occurs in the vasa recta- maintains osmotic gradient through opposite blood flow in hairpin vasa recta shape. going down, the blood picks up ions. going up, the blood leaves ions. this preserves the medullary osmolarity without created a new gradient, since the solutes are taken but then put back.
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Contraction of the bladder is controlled by
parasympathetic stretch receptors send signal to sacral cord
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how does the body urinate
A circular smooth muscle called the internal urethral sphincter relaxes, and (if the timing is appropriate) the voluntary external urethral sphincter relaxes as well. Urine flows from the bladder, through the urethra, and out of the body in a process called micturition.
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where is the internal urethral sphincter muscle located
between the bladder and the urethra
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how does the internal urethral sphincter work
its made of smooth muscle and its continuous with the detrusor muscle. The sympathetic nervous system keeps the IUS contracted until the micturition reflex is triggered. The IUS relaxes as a result of sympathetic inhibition, allowing urine to pass through
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how does external urethral sphincter work
made of skeletal muscle and under the control of the somatic nervous system. A conscious decision can be made to relax the EUS under appropriate circumstances. Involuntary contraction of the detrusor forces urine out of the body, and the voluntary contraction of abdominal muscles can increase the rate of flow by compressing the bladder.
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describe RAAS
When granular juxtaglomerular cells of the **afferent** arterioles of the kidneys detect a drop in blood pressure, they secrete an enzyme called renin. Renin interacts with a plasma protein called angiotensinogen, producing angiotensin I. As angiotensin I enters the capillaries of the **lungs**, it is acted on by another enzyme that converts it to angiotensin II. This hormone raises blood pressure by promoting vasoconstriction and stimulating the **adrenal cortex** to release aldosterone. Aldosterone increases the reabsorption of sodium, which increases water reabsorption, causing the blood volume and pressure to increase.
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im i am thirsty, does my osmoles of the blood go up or down
it will go up, because concentration of ions is higher
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how is osmoles detected in the blood
When **osmoreceptors in the hypothalamus** detect an increase in osmolality, signals are sent to the pituitary gland to release ADH. ADH causes the collecting ducts in the kidneys to be more permeable to water, and water crosses the epithelium from the urine into the interstitium where it is returned to the blood. As a result, the blood osmolality decreases, and urine osmolality increases.
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how CO2 travels in RBCs
CO2 + H20 = H2CO3 = HCO3 + H
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what are the waste products of the kidneys
ammonia, urea, uric acid, creatinine
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ammonia
toxic base from aa breakdown converted to urea by liver
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urea exits how
concentration of urea in the medulla which promotes reabsorption of water reabsorbed in the descending loop of henle
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uric acid
byproduct of the catabolism of purine nucleotides, and most of it is reabsorbed in the proximal tubule by active transport. Like urea, only a small percentage is excreted
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creatinine
Creatinine is produced in the muscles as a byproduct of the metabolism of creatine phosphate. It is filtered by the kidneys and excreted. Unlike urea and uric acid, creatinine is not reabsorbed by the tubules.
448
fever and inflammation: specifc or non specific?
nonspecific, innate immune system
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chemical barriers to infection
low pH of gastric juice, interferons that block viral replication, lysozyme in tears, and other antimicrobial proteins such as defensins, collectins, and complements.
448
first barriers to infection
skin and mucous membranes (mechanical)
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where do T cell mature
thymus
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what does T reg do
Regulatory (suppressor) T cells inhibit T and B cells to stop the immune response.
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thymus
site for T cell DIFFERENTIATION
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bone marrow does what two things
hematopoietic stem cells that ive rise to ALL WBC and RBC but site of DIFFERENTIATION for B cells
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MALT - location and what does it do
Mucosa-associated lymphoid tissue refers to the small clusters of lymphatic cells that are found in the **tonsils, appendix, and Peyer's patches of the small intestine.** T cells, B cells, and macrophages provide protection against pathogens.
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spleen red pulp vs white pulp
Splenic cords of the **red pulp** contain an abundance of **macrophages and lymphocytes** that help to filter aged blood cells, pathogens, and debris from the blood. The **white pulp **is a lymphatic tissue that consists almost entirely of **B and T cells**, and it provides a place for these lymphocytes to proliferate.
453
lymph nodes do three things
1. Provide a place for lymphocytes and other WBCs to proliferate (cortex contains B cells and macrophages, medulla contains T cells). 2. Filter the lymph of microorganisms, toxins, and wastes. 3. B cells produce antibodies that assist in the immune response.
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lymphatic system organs include
adenoids (in face), tonsils, lymph nodes, R lymphatic duct entering vein, spleen, BM, lymph vessel, thymus
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what is lymph?
Lymph is a clear liquid similar in composition to plasma. It is transported in one direction (toward the neck) where it is emptied into the subclavian veins. Lymph consists of white blood cells and the fluid that leaks out of the blood capillaries.
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what are lymph vessels' characteristics
Lymphatic vessels are similar in structure to veins; they have thin walls, and also have valves to prevent backflow. Their walls are more porous, however, allowing the lymph to drain into them for circulation lymph moves by contraction of muscle
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what happens at lymph nodes
lymphocytes are there to filter out foreign substances
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primary and secondary lymphatic organs
The primary organs of the lymphatic system (bone marrow and thymus) produce mature lymphocytes. There are also secondary organs (such as the spleen and tonsils) that house lymphocytes.
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how antibodies destroy pathogens
1. pathogens **agglutinate** (clump together) before being destroyed. 2. Antibodies can also **neutralize** the antigen by blocking its ability to attach to cells 3. or cause it to become insoluble and **precipitate** out of solution. 4 Sometimes, they activate **complement**—a system of proteins that enhances the effectiveness of the immune response. 5 Other cells of the immune system can be called to action, and phagocytosis can be enhanced in a process called **opsonization**. 6 Antibodies also promote **inflammation** to help slow the spread of infection.
459
fluid distribution between blood and tissues is a...
key function of the immune system. Greater hydrostatic pressure in the blood vessels (as compared to the interstitial fluid) causes fluid to leak out of the vessels into the surrounding tissues. Porous lymphatic capillaries collect excess interstitial fluid (now called lymph) for delivery to the right and left subclavian veins. As it travels through the lymphatic system, the lymph passes through lymph nodes where it is filtered and cleansed. Eventually, it reaches either the right lymphatic duct (which drains into the right subclavian vein) or the thoracic duct (which drains into the left subclavian vein), returning fluid back into the blood. If pressure is too great in the lymphatic vessels, edema will occur as fluid leaks back into the tissues.
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where is lymph found in the GI
The villi of the small intestine harbor specialized lymph capillaries called lacteals that absorb fats. These fats are transported in the form of chylomicrons, which give the lymph (called chyle) a whitish appearance.
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where does the thoracic duct drain into
the left subclavian vein
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where does the right lymphatic duct drain
right subclavian
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where do cells go that leaked out of the bloodstream
the lymph
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