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1
Q

How can cannabis help people?

A

While more study is needed, research indicates that cannabis can be helpful with things such as:
Helping to relief pain
Helping to reduce anxiety
Improved sleep
Better overall wellness
Weight loss
Diabetes prevention

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2
Q

How does cannabis relieve aches and pains?

A

Essentially, it blocks the pain pathways in the brain.

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3
Q

What is CBD especially helpful with?

A

Reducing anxiety and helping with sleep.

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4
Q

How does cannabis help with weight loss?

A

It helps the body regulate insulin and boosts its efficiency in managing caloric intake.

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5
Q

How does cannabis help prevent diabetes?

A

It may help stabilize blood sugar levels.

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6
Q

How does cannabis protect the brain?

A

It acts as a neuroprotector.

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7
Q

How would you define/describe Medical Marijuana?

A

Medical marijuana is the therapeutic use of the cannabis plant and comes in various forms, including tinctures, topicals, edibles, vaping, and more.

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8
Q

What are some of the best Strains for Pain?

A

ACDC
Blueberry
Catatonnic
Northern Lights
White Widow

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9
Q

In a nutshell, what is the ECS?

A
  • A network of receptors, lipids, and enzymes.
  • It controls balance (homeostasis) and affects how we respond to cannabis.
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10
Q

How does CBD help dampen THC?

A

CBD is a partial antagonist of the CB1 and CB2 receptors, meaning it can be used to block or dampen THC when used in equal doses.

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11
Q

Is CBD psychoactive?

A
  • CBD is thought to be non-psychoactive, but this is not entirely accurate.
  • CBD affects both dopamine and serotonin receptors, and also “talks” to opioid receptors.
  • CBD is not addictive, but certainly has physiological effects, and therefore could be seen as having psychoactive effects of sorts.
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12
Q

In a nutshell, what are cannabinoids?

A
  • Cannabinoids are like messengers that talk to our body through receptors.
  • Some are made by our body (endocannabinoids), like anandamide and 2-AG. - Some come from plants, especially cannabis (phytocannabinoids), like THC and CBD.
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13
Q

What are the big six cannabinoids?

A

CBD
CBC
CBG
CBN
THC
THCV

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14
Q

What cannabinoids are psychoactive?

A
  • THC
  • CBD is a little bit psychoactive as it comes from old THC.
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15
Q

Tell me about CBG.

A

CBG is like a parent to THC and CBD.

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16
Q

What does THCV do?

A

THCV - changes its effects with different amounts.

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17
Q

In essence, what do cannabinoids do?

A

Cannabinoids tell our body what to do. For example, THC tells your brain you’re hungry.

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18
Q

What are the two types of cannabinoids?

A
  • Phytocannabinoids are made by the cannabis plant.
  • Endocannabinoids are made by the body.
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19
Q

Differences between cannabinoids and terpenes? (5)

A
  • Terpenes have strong smells.
  • Terpenes are found in many plants, cannabinoids mainly in cannabis (with some exceptions).
  • Cannabinoids affect the endocannabinoid system (ECS), terpenes don’t directly impact the ECS.
  • Terpenes can influence the entourage effect and how cannabinoids work in the body.
  • Both cannabinoids and terpenes are types of terpenoids, and terpenes might mimic cannabinoid effects.
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20
Q

What do terpenes do?

A

Terpenes can influence the entourage effect and how cannabinoids work in the body.

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21
Q

What are two types of terpenoids?

A

Both cannabinoids and terpenes are types of terpenoids.

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22
Q

What might terpenes mimic?

A

Terpenes might mimic cannabinoid effects.

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23
Q

What is the cannabimimetic effect?

A

When terpenes approximate the behavior and feeling of cannabinoids without necessarily affecting the ECS directly.

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24
Q

How do terpenes affect the entourage effect?

A

Terpenes affect receptor systems in the body, so they can contribute to the entourage effect.

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25
What is something that is very important to determine the effect a particular cultivar (chemotype) of cannabis has?
Terpene makeup of a variety of cannabis is very important to determine the effect a particular strain of cannabis has.
26
What is the ECS is involved with?
The ECS is involved with sleep, appetite, immune function, and virtually every critical life function
27
Where is the endocannabinoid system (ECS) found?
All humans and many animals have an endocannabinoid system (ECS).
28
What is the ECS a network of?
The ECS is a network of receptors, lipids, and enzymes.
29
What does the ECS do?
It controls balance (homeostasis) and affects how we respond to cannabis.
30
What is the ECS sometimes referred to?
The ECS is sometimes called "the master regulator."
31
What are the three main parts of the ECS?
The ECS has three main parts: endocannabinoids, enzymes, and receptors. (EER)
32
What is CBD known for?
cannabidiol (CBD), known for promoting relaxation
33
What is THC known for?
THC is known for its intoxicating effects
34
What is CBD short for?
Cannabidiol
35
What is THC short for?
Tetrahydrocannabinol
36
What happens when the ECS is out of balance?
When the ECS is imbalanced, it can lead to problems, even diseases.
37
What is the body's version of cannabinoids?
Endocannabinoids
38
What are the primary endocannabinoids?
- Anandamide (AEA) - 2-AG
39
What is anandamide? What does anandamide do?
- Anandamide is the human body’s naturally occurring THC. - It interacts with the body similarly to THC, which induces euphoric highs in many individuals.
40
What does 2-AG do?
2-AG can have both pain-killing and anti-inflammatory effects.
41
Where is 2-AG mostly found in humans?
At relatively high levels in the central nervous system (CNS).
42
Where do endocannabinoids bind?
Endocannabinoids bind to receptors all over the body, including the immune system, nervous system, and skin. (INS)
43
Tell me about the main endocannabinoids.
- Anandamide is similar to THC and makes you feel happy. - 2-AG can reduce pain and inflammation, found in the nervous system.
44
Where is 2AG mainly found?
The central nervous system (CNS).
45
Where are cannabinoid receptors found?
Cannabinoid receptors are found in every cell in the human body.
46
What do cannabinoid receptors make the ECS work like? Where does this happen?
Cannabinoid receptors make the ECS work like a mainframe. This happens in the central and peripheral nervous systems (CNS and PNS).
47
What do cannabinoids and endocannabinoids, communicate directly or indirectly with?
Receptors
48
What receptors do cannabinoids and endocannabinoids communicate directly or indirectly with?
A wide range of receptors, including: CB1 CB2 dopamine opioid serotonin GPR55 many more. (CCDOSG)
49
Where are CB1 receptors are most dense?
CB1 receptors are most dense in the central nervous system (CNS).
50
What is CB1 mainly responsible for?
CB1 receptors are mainly responsible for how cannabinoids interact with the brain.
51
Give an example of how CB1 might work.
Molecules like THC bind to CB1 receptors and cause psychoactive “high” effects.
52
What causes the psychoactive "high" effects?
When molecules like THC bind to CB1 receptors.
53
How exactly do cannabinoids have this "high" effect on brain cells?
Cannabinoids that bind to CB1 receptors can decrease the release of two proteins called glutamate or GABA (gamma-aminobutyric acid).
54
What does glutamate do?
Glutamate stimulates or excites the nervous system.
55
What does GABA do?
GABA calms down the nervous system.
56
Are glutamate and GABA at the same levels usually?
No, when glutamate levels are high, GABA levels are often low, and vice-versa.
57
What is the simple glutamate and GABA equation?
Glutamate = go, GABA = stop
58
What does THC block the production of?
THC blocks the production of GABA.
59
What happens when THC blocks the production of GABA? What does this create?
- It means that fewer “stop” signals are transmitted. - This creates a buildup of the “go” signal glutamate, which can increase the overall amount of dopamine circulating in the body, which then causes a psychoactive “high.”
60
What are several effects the activation of CB1 causes?
Impacts our sense of time Increases appetite and desire for food Pain-killing or pain-distracting effects Affects mood (up or down) Anti-nausea effects (TAMPA)
61
Where are CB2 receptors mostly found?
CB2 receptors can be found most densely in the immune system.
62
What does research indicate CB2 may be most crucial in helping with?
CB2 may prove crucial for people with cancerous tumors and precancerous cells.
63
What does CB1 activation affect?
THC's "high" effect Time perception Appetite Mood (up or down) Pain relief Anti-nausea (TAMPA)
64
Where are CB2 receptors found?
immune system some brain cells the gut PNS (peripheral nervous system)
65
What system does CB2 activate? What does that have to do with cancer?
immune response - cell death - cell development
66
What can CB2 help with?
autoimmune disorders arthritis pain inflammation (AAPI)
67
What role do enzymes play in the ECS?
Enzymes help break down cannabinoids and endocannabinoids to stop any excess, to help maintain the ECS balance.
68
What does the ECS do? Give examples.
The ECS is involved in regulating many of life’s most essential processes. This includes: Reward perception. Reproduction. Inflammatory response. Immune system function. Appetite. Pain sensation. Mood. Memory. The pleasurable effects of exercise. And, of course, mediating the pharmacological and experiential impact of cannabis. AMMPIIRR

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