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Flashcards in TEN Deck (8)
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1
Q

TEN - presentation, examination finding

A

scalded appearance to skin over extensive area
systemically unwell
Nikolsky’s sign - epidermis separates on mild lateral pressure

2
Q

drugs that can induce TEN

A

anticonvulsants - phenytoin + carbamazepine
allopurinol
penicillin / antibiotics
NSAIDs

3
Q

How long after ingestion of a drug can TEN occur?

A

2 months - mainly anticonvulsants that take this long

4
Q

Oxygen sats cut off for treatment

A

94-98% is the aim - give O2 if below this

5
Q

TEN - management

A

conservative:
ICU
stop precipitant
v greasy ointment + non adhesive dressing

1° - IV immunoglobulin
other - ciclosporin / cyclophosphamide, plasmapheresis, steroids

6
Q

TEN - outcomes

A

septic shock + multi-organ failure

long term:
scarring
psychological + not wanting meds
inability to sweat
eye complications
chronic erosion mouth + genitals
7
Q

What scoring system is used for TEN?

A

SCORTEN - for mortality prediction

8
Q

Risk of patch testing

A

Patch testing can trigger sensitivity (not necessarily TEN, more for allergies)
TEN Can’t happen first time trying a drug
But cross-sensitivity can mean reaction to a new drug is due to sensitisation to a different drug had previously (?)