tenecteplase

Question 1

Indications

Answer 1

STEMI when following the fibrinolytic pathway.

Question 2

Contraindications and cautions

Answer 2

Contraindications:
A Known severe allergy.

Cautions
LOTS CHECK CPGS.
More than 10 minutes of CPR

Question 3

Action

Answer 3

Tenecteplase is a fibrinolytic that accelerates the breakdown of blood clots. It converts the plasma protein plasminogen into the active enzyme plasmin, which breaks down the fibrin within blood clots.

Question 4

Route

Answer 4

IV / IO

Question 5

Dosage

Answer 5

Weight based:
reducing dose for age significantly reduces adverse side effects

Question 6

Side effects

Answer 6

Common adverse effects of tenecteplase:

– Bleeding. Tenecteplase commonly causes superficial bleeding, including epistaxis,
bruising and bleeding from IV sites.

– Dysrhythmia. It is common for dysrhythmia to occur if the coronary artery reperfuses.
Most commonly the rhythm is an accelerated idioventricular rhythm (AIVR) which does not require specific treatment. Other dysrhythmias should be treated using the appropriate
section of the CPGs.