Teratogens Flashcards
Growth restriction, mental retardation
Midfacial hypoplasia, smooth philthrum of lip
Renal and cardiac defects, ASD
Fetal alcohol syndrome
Female virilization, advanced genital development
Androgens
Microcephaly, neural tube defects
Fingernail hypoplasia
IUGR, developmental delay
Carbamazepine
Bowel artresia
Heart, limb, face, GU malformations
IUGR
Microcephaly, cerebral infarctions
Cocaine
Cerebral atrophy, microcephaly, mental retardation
Spasticity, seizures, blindness
Organic mercury
Clear cell adenocarcinoma of the vagina/cervix
Vaginal adenosis
Abnormalities of cervix/uterus/testes
Infertility
DES
Increased SAB rate
Stillbirth
Lead
IUGR Mental retardation, microcephaly Cardiac defects Fingernail hypoplasia Dysmorphic craniofacial features
Phenytoin
Ebstein’s anomaly
Lithium (congenital heart disease)
Increased SAB rate (chemotherapy drug)
MTX
Increased SAB rate
Microtia, thymic agenesis, craniofacial dysmorphism, micropthalmia, cleft lip/palate
CV defects
Mental retardation
Vitamin A
Fetal renal tubular dysplasia
Neonatal renal failure
Oligohydramniosis, IUGR
Lack of cranial ossification
ACE- inhibitors
Hearing loss (CN VIII damage)
Streptomycin and kanamycin
Microcephaly and mental retardation
Radiation
b/l limb deficiencies
Anotia/micronotia (absence of auricle)
Cardiac and GI abnormalities
Thalidomide
