Test 1 Flashcards
1
Q
What kind of group is shown here
A
Alkyl group
2
Q
What kind of group is shown here?
A
Aromatic group
3
Q
What kind of group is shown here?
A
Hydroxyl group
4
Q
What kind of group is shown here?
A
Phenol
5
Q
What kind of group is shown here?
A
Ether
6
Q
What kind of group is shown here?
A
Ester
7
Q
Is an alkyl group hydrophobic or hydrophilic?
A
Hydrophobic
(just a group of carbons)
8
Q
Is an aromatic group hydrophilic or hydrophobic?
A
Hydrophobic
(a ring of C’s with alternating double bonds)
9
Q
What makes a hydroxyl group hydrophilic?
A
The ability of the OH dipole to create a dipole dipole bond with WATER
10
Q
Is a phenol hydrophobic or hydrophilic?
A
Hydrophilic
(an aromatic ring and an OH group that creates a dipole)
11
Q
Why is an ether only weakly hydrophilic?
A
Because it has a dipole between the O and C but no OH group so it can not donate an H bond
12
Q
Is an ester hydrophobic or hydrophilic?
A
Hydrophilic due to the resonance of the two O’s and the double bond
13
Q
What are the boding capabilities of alkyl groups?
A
Vander Waals
14
Q
What are the bonding capabilities of aromatic groups?
A
Vander Waals but specifically pi-pi stacking
15
Q
What are the bonding capabilities of a hydroxyl group?
A
Dipole-dipole (hydrogen bonding)
Ion-dipole
16
Q
What are the bonding capabilities of phenols?
A
Dipole-dipole
Hydrogen bonding
Pi-pi stacking (vander waals)
17
Q
What are the bonding capabilities of an ether?
A
H bonding
Vander waals
18
Q
What are the bonding capabilities of an ester?
A
H bonding
Van der Waals
19
Q
Is an alkyl group an h bond acceptor or donator?
A
Neither
20
Q
What is the pKa of alkyl group?
A
None
21
Q
Is a hydroxyl group an h bond acceptor or donator?
A
Both but has no pKa or acidic properties
22
Q
What is the pKa of a phenol?
A
9-10 (pKa is brought down due to the resonance of double bonds)
23
Q
Is phenol an H bond acceptor or donator?
A
Both (weak acid)
24
Q
Is an ether a h bond acceptor or donator?
A
Acceptor only
Does not have an H on the O
25
Is an ester an H bond acceptor or donator?
Acceptor only
26
What functional group is shown here?
Carboxylic acid
27
What functional group is shown here?
Aromatic ether
28
What bonding capabilities does a carboxylic acid have?
H bonding
Ion dipole
29
Is a carboxylic acid an H bond donor or acceptor
Both
30
What is the pKa of a carboxylic acid?
2-5
31
Is an aromatic ether acidic basic or neither?
Neither
32
Is an aromatic ether an H bond acceptor or donor?
Acceptor
33
What bonding capabilities does an aromatic ether have?
H bonding
Pi pi stacking
34
What functional group is shown here?
Aromatic ester
35
What functional group is shown here?
Sulfhydryl/ thiol
36
What functional group is shown here?
Thioether
37
What functional group is shown here?
Sulfonamide
38
What functional group is shown here?
Sulfonylurea
39
What functional group is shown here?
Alkyl amine
40
What functional group is shown here?
Aromatic amine
41
What functional group is shown here?
Aromatic heterocycle
Pyrrole
42
Is a carboxylic acid hydrophilic or phobic?
Hydrophilic
43
Is a thiol hydrophilic or phobic?
Hydrophilic
44
What bonding capabilities do aromatic esters have?
Pi pi stacking
H bonding
45
What are the bonding capabilities of a thiol?
H bonding
46
Is a thiol an h bond acceptor or donor
Both
47
Is a thiol acidic or basic and what is the pKa
Mildly acidic
10-11
48
Is a thioether hydrophilic or hydrophobic?
Hydrophilic
49
What are the bonding capabilities of a thioether?
H bonding
Vander Waals
50
Is a thioether an h bond acceptor or donor?
Acceptor
51
Is a thioether acidic or basic?
Neither
52
Is a sulfonamide hydrophilic or hydrophobic?
Hydrophilic
53
What bonding capabilities does sulfonamide have?
H bonding
Ion dipole
54
Is a sulfonamide an H bond acceptor or donor?
Both
55
Is a sulfonamide an acid or a base?
Acid
56
hat is the pka of a sulfonamide?
4-11 (resonance)
57
Is sulfonylurea hydrophilic or hydrophobic?
Hydrophilic
58
What are bonding capabilities of sulfonylurea?
H bond
Ion dipole
59
Is a sulfonylurea an h bond acceptor or donor?
Both
60
Is sulfonylurea acidic or basic
Acidic
61
What is the pKa of a sulfonylurea?
5-6
62
Is an alkyl amine hydrophobic or hydrophilic?
Hydrophilic
63
Is aromatic amine hydrophilic or hydrophobic?
Hydrophilic
64
Is pyrrole hydrophilic or hydrophobic?
Hydrophilic
65
What are the bonding capabilities of an alkyl amine?
H bonding
66
What are the bonding capabilities of an aromatic amine
H bonding
Ion dipole
Pi pi stacking
67
What are the bonding capabilities of a pyrrole?
Pi pi stacking
H bonding
Ion dipole
68
Is an alkyl amine an h bond acceptor or donor?
Both
69
Is an aromatic amine an h bond donor or acceptor?
Both
70
Is a pyrrole an h bond acceptor or donor?
Both
71
Is an alkyl amine acidic or basic and what is its pKa?
Basic 9-11
72
Is an aromatic amine basic or acidic and what is the pKa?
Weakly basic
2-5
73
Is a pyrrole basic or acidic and what is the pKa?
Weakly basic
1-3
74
What functional group is shown here?
Indole
75
What functional group is shown here?
Imidazole
76
What functional group is shown here?
Pyridine
77
What functional group is shown here?
Amide
78
What functional group is shown here?
Amidine
79
What functional group is shown here?
Guanidine
80
What functional group is shown here?
Carbamate
81
What functional group is shown here?
Urea
82
What functional group is shown here?
Carbonate
83
Is an indole hydrophilic or hydrophobic?
Hydrophilic
84
Is an Imidazole hydrophilic or hydrophobic?
Hydrophilic
85
Is a pyridine hydrophilic or hydrophobic?
Hydrophilic
86
Is an amide hydrophilic or hydrophobic?
Hydrophilic
87
Is an amidine hydrophilic or hydrophobic?
Hydrophilic
88
Is a guanidine hydrophilic or hydrophobic?
Hydrophilic
89
Is a carbamate hydrophilic or hydrophobic?
Hydrophilic
90
Is urea hydrophilic or hydrophobic?
Hydrophilic
91
Is carbonate hydrophilic or hydrophobic?
Hydrophilic
92
What are the bonding capabilities of an indole?
H bonding
ion dipole
pi pi stacking
93
What are the bonding capabilities of imidazole?
H bonding
Pi pi stacking
Ion dipole
94
What are the bonding capabilities of pyridine?
H bonding
Pi Pi stacking
95
What are the bonding capabilities of amide?
H bonding
96
What are the bonding capabilities of guanidine?
H bonding
Ion dipole
97
What are the bonding capabilities of amidine?
H bonding
ion dipole
98
What are the bonding capabilities of carbomate?
H bonding
99
What are the bonding capabilities of urea?
H bonding
100
What are the bonding capabilities of Carbonate?
H bonding
101
H bond acceptor donor both or neither - indole?
both
102
H bond acceptor donor both or neither - imidazole?
both
103
H bond acceptor donor both or neither - pyridine?
acceptor
104
H bond acceptor donor both or neither - amide?
Both
105
H bond acceptor donor both or neither - guanidine?
Both
106
H bond acceptor donor both or neither - amidine?
Both
107
H bond acceptor donor both or neither - carbamate?
both
108
H bond acceptor donor both or neither - urea?
both
109
H bond acceptor donor both or neither - carbonate?
acceptor
110
Acid basic neither and pka - indole?
Weakly basic 2
111
H bond acceptor donor both or neither pKa - imidazole?
Highly basic 13-14
112
H bond acceptor donor both or neither pKa - pyridine?
Weakly basic 5-6
113
H bond acceptor donor both or neither pKa -amidine?
Basic 10-11
114
H bond acceptor donor both or neither pKa - amide?
Neither
115
H bond acceptor donor both or neither pKa - Guanidine?
Very basic 12-13
116
H bond acceptor donor both or neither pKa - carbomate?
neither
117
H bond acceptor donor both or neither pKa - urea??
neither
118
H bond acceptor donor both or neither pKa - carbonate?
neither
119
What interactions happen in vander waals?
Momentary uneven charges between carbons
120
Are vander waals distant dependent or independent?
Very distant dependent
121
What functional groups can do pi pi stacking?
Aromatic rings
122
What is happening during dipole induced dipole?
Electrons are shifting in the molecule in molecule with dipole that creates a temporary dipole in the non dipole molecule
123
What is the most common interaction of weak bonds?
Dipole dipole interactions
124
What drugs would need to have covalent bonds?
Chemotherapy
Antifungal
Anti bacterial
125
Why are covalent bonds toxic in the body?
They are not reversible so cannot be excreted
126
What does pKa represent?
How well the molecule can stabilize a charge
127
What is solvation and dissolution?
ability to be solvated and dissolved in the body
128
Where do hydrophilic drugs go in the body?
In the plasma
Plasma is majority water
129
What is a negative of a hydrophilic drug?
The drug cannot cross the membrane to be metabolized
130
Does a hydrophilic drug have high or low levels of excretion?
High
131
Does a hydrophilic have a long or short duration of action?
short
132
Where do hydrophobic drugs go in the body?
To the fatty parts of the body
Go to albumin in the blood
133
Which drug has a higher volume of distribution- hydrophilic or hydrophobic?
Hydrophobic
134
What is metabolism?
The body getting rid of things that arent itself like a drug
