Test 1

Question 1

phosphatidylserine (PS)

Answer 1

cytoplasmic surface

Question 2

phosphatidlylethanolamine (PE)

Answer 2

glycerophospholipid with ethanolamine

Question 3

phosphatidlycholine (PC)

Answer 3

glycerophospholipid with choline

Question 4

phosphatidylinositol (PI)

Answer 4

precursors to signaling molecules

Question 5

phosphatidlyglycerol (PG)

Answer 5

glycerophospholipid with glycerol

Question 6

diphosphatidylglycerol (DPG)

Answer 6

prominent in mitochondrial inner membrane, cardiolipin

Question 7

phospholipase

Answer 7

hydrolyze phospholipid

Question 8

PLA1

Answer 8

breaks ester bond between C1 and FA

Question 9

PLA2

Answer 9

breaks ester bond between C2 and FA

Question 10

PLB

Answer 10

breaks ester bond between C1 or C2 and FA

Question 11

PLC

Answer 11

breaks ester bond between C3 and phosphate

Question 12

PLD

Answer 12

breaks ester bond between phosphate and base

Question 13

sphingophospholipids

Answer 13

eukaryotic cells, nerve cells, extracellular

Question 14

sphingoglycolipids

Answer 14

extracellular

Question 15

cerebroside

Answer 15

sphingoglycolipid, 1 sugar, extracellular

Question 16

globoside

Answer 16

sphingoglycolipid, >1 sugar

Question 17

ganglioside

Answer 17

sphingoglycolipid, >1 sugar, sialic acid, blood groups

Question 18

sterol

Answer 18

fused ring nucleus, polar group, acyl tail, eukaryotes

Question 19

cholesterol

Answer 19

animal membranes, precursor

Question 20

sterol function

Answer 20

rigid membrane, reduces permeability, adjusts membrane packing, affects transition temp

Question 21

phase transition

Answer 21

change of state liquid to gel

Question 22

chaperones

Answer 22

interact with hydrophobic residues at end of chain

Question 23

hsp70

Answer 23

act early, bind to exposed hydrophobic patches

Question 24

hsp60

Answer 24

act late, large barrel structures

Question 25

proteasome

Answer 25

protein recycling

Question 26

ubiquitin

Answer 26

destruction tag, C-terminal gly bonds to polypeptide, n terminal lys links to more ubiquitin

Question 27

E1

Answer 27

ubiquitin activating enzyme, forms thioester bond at C terminus

Question 28

E2

Answer 28

ubiquitin conjugating enzyme

Question 29

E3

Answer 29

ubiquitin ligase, transfers ubiquitin to target protein

Question 30

degron

Answer 30

degradation signal

Question 31

N end rule

Answer 31

powerful degradation signal created by cleavage of peptide bonds which creates new N-terminus

Question 32

kinase

Answer 32

phosphorylates

Question 33

phophatase

Answer 33

remove phosphate

Question 34

Type 1 membrane protein

Answer 34

transmembrane, C inside

Question 35

Type 2 membrane protein

Answer 35

transmembrane, C outside

Question 36

Type 3 membrane protein

Answer 36

multiple transmembrane domains

Question 37

Myristic acid

Answer 37

cytoplasmic face, bound to acyl chain, amide bond formed with N gly, static anchor

Question 38

Palmitic acid

Answer 38

cytoplasmic face, bound to acyl chain, thioester with cys, dynamic anchor

Question 39

polyisoprene anchors

Answer 39

cytoplasmic face, anchor signal transduction or protein targeting

Question 40

farnesyl

Answer 40

polyisoprene, 3

Question 41

geranylgeranyl

Answer 41

polyisoprene, 4

Question 42

glycophosphatidylinositol (GPI)

Answer 42

protein anchor, extracellular face, long lived proteins

Question 43

GPI structure

Answer 43

C terminus - phosphoethanolamine - sugar - phosphatidylinositol

Question 44

Porin

Answer 44

Beta barrel transmembrane protein

Question 45

glycophorin

Answer 45

type 1 membrane, links to membrane skeleton