Test 1 Flashcards
(31 cards)
the science of blood group systems and the possible antigen-antibody reaction in relation to the blood transfusion
immunohematology
oligosaccharides attach to cell membrane
glycolipid
oligosaccharides attach to protein structure
glycoprotein
antigens found in solution
substances
antibody production that is made in response to the antigens you are exposed to in nature
naturally occurring antibodies
antibody produced due to exposure to a foreign antigen from transfusion, pregnancy, transplantation
immune response antibodies
the science of blood group systems and the possible antigen-antibody reaction in relation to the blood transfusion
immunohematology
any substance that when introduced to the body can elicit an immune response
antigen
protein substance in serum secreted by plasma cells during an immune response, interacts with an antigen
antibody
ability of an antigen to stimulate an antibody response
immunogenicity
strength of a single antigen-antibody bond produced by the summation of attractive and repulsive forces
affinity
binding strength of a multivalent antigen with antisera produced in an immunized individual
avidity
measure of the strength of an antibody by testing its reactivity at increasing dilutions
titer
portion of the antigen molecule that reacts with the antibody
epitope
related to an antibody’s relative avidity for antigen; a specific reaction, cross reaction, or no reactions
specificity
antibodies produced in response to non self antigens
alloantibodies
antibodies produced in response to self-antigens
autoantibodies
antibody binding fragment-binding sites on the variable region
Fab region
crystallizable fragment-responsible for complement activation, fixation to skin, and placental transport
Fc region
Their function is to phagocytize foreign antigens
antigen presenting cells
antigen presentation and stimulating B cell product and function
no surface bound Ig
T lymphocytes
have monomeric IgM and IgD on their surface
Express HLA antigens
undergo clonal division producing plasma cells and memory B cells
B lymphocytes
don’t carry Ig on their surface
synthesize and secrete antibody with specificity determined by the parent B cell
plasma cells
repulsion between RBC’s due to negative charge
zeta potential