Test 2

Question 1

Cmax correlates with:

Answer 1

both rate and extent of absorption

Question 2

bioavailability depends on

Answer 2

both rate and extent

Question 3

cpmax is decreased by

Answer 3

a decrease in rate of absorption

Question 4

If the absorption rate for formulation A was SLOWER than formulation B and relative rate of absorption for A was the same as B then:

Answer 4

cman for A would be less than B

Question 5

if the extent of absorption was LESS for product A than B and relative rate of absorption for A was the same as B then:

Answer 5

cmax for B would be higher than A

Question 6

Drug A and B bind to the same albumin molecule: A is already being given to pt. what is correct concerning giving drug B

Answer 6

at the same concentrations the drug with the higher Ka will have the lowest Fu

Question 7

two drugs compete for the same binding site on a protein. what condition would yield higher binding for A than B?

Answer 7

higher [A]

Question 8

when a drug undergoes hepatic metabolism, the kinetics appear first order when

Answer 8

[drug] are lower than the value of the Km

Question 9

the effect of Vmax on the rate of drug metabolism when a single bolus dose is given would show:

Answer 9

the observed half life for metabolism would be smaller for larger Vmax values

Question 10

What is the characteristic of simple competitive inhibition

Answer 10

having the same Vmax, but a larger Km when the inhibitor is present

Question 11

What 2 things are expected if plotting Cmax(axis) vs % dissolved at 30 minutes

Answer 11

1) as the % dissolved decreased, the max value would decrease
2) as the % dissolved increased, the max value would increase

Question 12

smoking is considered an environmental enzyme inducer for some drugs. if pt stops smoking after being stabilized on a drug, you expect

Answer 12

drug levels of drug to increase

Question 13

the classic full crossover bioavailability testing corrects for

Answer 13

the differences between people

Question 14

a repeated, full crossover design corrects for

Answer 14

BOTH the variability within the same subject and between different subjects

Question 15

if the full crossover design is not repeated, it does not correct for

Answer 15

variability within the same subject

Question 16

absolute bioavailability is obtained by comparing results from a particular drug product or dosage for and comparing it to

Answer 16

data from an IV bolus dose

Question 17

bioavailability of a drug deals with

Answer 17

rate and extent of absorption

Question 18

relative bioavailability compares

Answer 18

a new product or formulation to an existing formulation

Question 19

absolute availability could

Answer 19

be qual to zero

Question 20

can absolute bioavailability be equal to zero?

Answer 20

yes

Question 21

absolute bioavailability cannot

Answer 21

be greater than 1

Question 22

absolute availability (F)=1 when

Answer 22

ALL of drug is absorbed

Question 23

Tmax is

Answer 23

the time of peak plasma concentration

Question 24

AUC measures

Answer 24

the extent of drug bioavailability

Question 25

AUC is the area under the drug plasma levels time curve

Answer 25

and is equal to the amount of unchanged drug reaching the general circulation divided by the drug clearance

Question 26

Units for AUC are

Answer 26

concentration time

Question 27

AUC is not proportional if one of the pathways for elimination becomes saturated, which causes

Answer 27

prolonged half life

Question 28

Tmax is the best indicator of

Answer 28

the relative rate of drug absorption

Question 29

if the absorption rate for A was faster than B, but the extent of absorption was the same for A and B then tmax

Answer 29

for A would be less than B

Question 30

if bioavailability is less than 1, and the AUC obtained by a direct intraportal inject is the same as when you gave the same dose of drug orally:

Answer 30

the drug was subject to first pass metabolism

Question 31

An IV bolus dose and a capsule are given. Rate of urinary excretion is measured and plotted. this data:

Answer 31

can be used to estimate bioavailability of the capsule formulation

Question 32

in correlating cpm values in vivo with the % dissolved in vitro at time=20 minutes, we expect, if a correlation exists that

Answer 32

cpmax will be smaller if the dissolution rate is slower

Question 33

The boys whitney eqn predicts

Answer 33

if the particle size is smaller the dissolution rate will potentially be faster

Question 34

the absorption of a very lipid soluble, unionized drug molecule, will most like be eliminated by rate of

Answer 34

dissolution

Question 35

to pass the dissolution test in stage 1 (first 6 units)

Answer 35

no result is less than Q + 5%

Question 36

the absorption of a very lipid soluble, unionized but somewhat water soluble drug will be limited by rate of

Answer 36

perfusion

Question 37

dissolution rate of a weak acid

Answer 37

may be slower at a lower pH

Question 38

a drug that would be limited by diffusion rate rather than perfusion rate is most likely

Answer 38

a polar water soluble drug of a large size

Question 39

usually disintegration is

Answer 39

not rate limiting, but may be if intended

Question 40

clearance of a drug:

Answer 40

is constant for a physiologically stable person who eliminates the drug as a first order process

Question 41

clearance can be calculated by

Answer 41

extraction ration * blood flow

Question 42

compare drug elimination and clearance

Answer 42

elimination rate changes over time while clearance is constant

Question 43

renal cleraance eqn

Answer 43

GFR + active secretion - reabsorption

Question 44

oxidation, reduction and hydrolysis rxns are

Answer 44

phase I reactions

Question 45

the most frequently found conjugation reaction involves

Answer 45

glucuronic acid

Question 46

for a drug known to exhibit non linear pharmacokinetics, as dose increases:

Answer 46

the steady state concentration increases more than predicted amount of dose increase

Question 47

passive tubular reabsorption would be lowest for

Answer 47

a weak base at pH 2

Question 48

passive tubular reabsorption would be highest for

Answer 48

a weak acid at pH 3

Question 49

passive reabsorption of a drug:

Answer 49

reduces renal clearance

Question 50

ionization of a weak base

Answer 50

decreases its lipid solubility

Question 51

active secretion of a drug by the renal system:

Answer 51

increases renal clearance

Question 52

facilitated diffusion occurs

Answer 52

only in the presence of a carrier

Question 53

a carrier mediated process for a drug absorption

Answer 53

will saturated carrier at drug concentrations approximately twice the value of Km

Question 54

passive diffusion

Answer 54

rate increases in direct proportion to drug concentration

Question 55

all drugs are subject to some biliary clearance,

Answer 55

is subject to enhancement by active secretion into the bile

Question 56

A scatchard plot is used to determine

Answer 56

Ka and n

Question 57

the r in the protein binding equation what does it stand

Answer 57

equals ratio of moles of drug bound per total mole of protein

Question 58

the n in protein binding eqn refers to

Answer 58

the number of sites for a particular drug per protein molecule

Question 59

the apparent Vd will be very large when

Answer 59

the drug is more bound to tissues than plasma proteins

Question 60

IV administration is assumed

Answer 60

to be 100% bioavailable

Question 61

IM injections can be used

Answer 61

for oil based or insoluble components

Question 62

rectal admin provides:

Answer 62

good absorption from solutions retained long enough

Question 63

buccal route is preferred to oral when

Answer 63

drug is subject to high first pass metabolism

Question 64

a suspension drug form may be necessary for

Answer 64

aqueously insoluble or unstable drugs