Test 2

Question 1

Coagulation proteins (factors)
2 forms

Answer 1

1. Inactive form-in circulation-Zymogen
2. Activated from-interact to from fibrin clot
   * designated bu Roman Numerals

Question 2

Purpose of coagulation proteins?

Answer 2

to reinforce the platelet plug

Question 3

Where are all the factors produced?

Answer 3

Liver

Question 4

Activated form?

Answer 4

“a”

Question 5

Factor I

Answer 5

Fibrinogen

Question 6

Factor II

Answer 6

Prothrombin

Question 7

Factor III

Answer 7

Tissue Factor (tissue thromboplastin)

Question 8

Factor IV

Answer 8

Ionized Calcium

Question 9

Factor V

Answer 9

Labile Factor (proaccelerin)

Question 10

Factor VII

Answer 10

Stabile factor (serum prothrombin conversion accelerator SPCA), proconvertin.

Question 11

Factor VIII

Answer 11

Antihemophilic factor, factor VIII:C (coagulation portion)

Question 12

Factor IX

Answer 12

Christmas Factor, Plasma thromboplastin component (PTC), antihemophilic factor B

Question 13

Factor X

Answer 13

Stuart-Prower Factor

Question 14

Factor XI

Answer 14

Plasma Thromboplastin Antecedent (PTA)

Question 15

Factor XII

Answer 15

Hageman Factor (contact factor)

Question 16

Factor XIII

Answer 16

Fibrin-stabalizing factor (FSF)

Question 17

Fitzgerald factor

Answer 17

High-Molecular Weight Kininogen (HMWK)

Question 18

Fletcher factor

Answer 18

Prekallikrein

Question 19

Coagulation proteins classified by function?

Answer 19

1-Substrates
2-Co-factors
3-Enzymes

Question 20

Substrates

main substrate?

Answer 20

Fibrinogen

Question 21

Co-factors?

Answer 21

1-Factor V-labile factor

2-VIII:C-antihemophilic factor (AHF)

Question 22

Enzymes?

Answer 22

Serine proteases-includes all except XIII (IIa,VIIa,IXa,Xa,
XIa,XIIa, and prekallikrein)

Transaminases-includes only Factor XIIIa (creates cross linking)

Question 23

Classified by Physical Properties?

Answer 23

1-Contact proteins

2-Vitamin K dependent (Prothrombin Proteins)

Question 24

Contact Protiens

Answer 24

not consumed in normal clotting process

• involved in initial phase of intrinsic activation
• includes XII,XI,prekallikrein,HMWK

Question 25

Vitamin K Dependent (prothrombin proteins)

Answer 25

1-Factors-1,7,9,10 (Factor 7 has shortest half life) | 2-inhibitors-protein C and S

Question 26

Vitamin K deficient patients have decreased/increased | production of functional prothrombin proteins & inhibitors.

Answer 26

decreased | *PT monitors Coumadin

Question 27

Coumarin, Coumadin, Warfarin

Answer 27

- inhibit Vit K reduction yielding inactive factors | * only active in vivo (unlike heparin)

Question 28

Acquired Vitamin K deficiencies commonly seen in?

Answer 28

- post surgical procedures - high dose antibiotic use - liver disease

Question 29

Fibrinogen or Thrombin sensitive proteins

Answer 29

Includes Factors: I,V,VIII:C and XIII

Question 30

Thrombin acts no all factors in the fibrinogen group | factors: I,V,VIII:C and XIII

Answer 30

- enhances activity of factors V & VIII:C - Activates factor XIII - converts fibrinogen to fibrin

Question 31

Actions of Thrombin

Answer 31

- Procoagulant effects - Coagulation inhibitor effects - Initiates Tissue Repair

Question 32

Procoagulant effects

Answer 32

- Positive feedback: factor V & VII - Converts Factor 1 to soluble fibrin monomer - Activates XIII - Induces platelet activation & aggregation by promoting secretion of serotonin & TXA2

Question 33

Coagulation inhibitor effects

Answer 33

- binds to Antithrombin (AT), if heparin present AT enhanced 200x - Promotes release of t-PA (Tissue Plasminogen Activator) - Binds to thrombomodulin-activates protein C (neg feedback on Va & VIIIa)

Question 34

Initiates Tissue Repair

Answer 34

- Induces chemotaxis | - Stimulates proliferation of smooth muscle & endothelial cells

Question 35

Extrinsic Pathway

Answer 35

Measured by Protime (PT)

Question 36

Type of anticoagulant affects Extrinsic Pathway?

Answer 36

Coumadin

Question 37

Reagents used in PT (Protime)?

Answer 37

Thromboplastin & Calcium

Question 38

Extrinsic Pathway initiated by...

Answer 38

tissue factor (provides a phospholipid surface not normally found in blood) as it enters the vascular system.