Test 2

Question 1

RBC transfusions

Answer 1

Type 2

Question 2

Hemolytic Disease of Newborn

Answer 2

Type 2

prevent with anti-RhD commercial IgG Rhogam shot

Question 3

idiopathic hemolytic anemia

Answer 3

Type 2

Question 4

Thrombocytopenia

Answer 4

Type 2

Question 5

Cole agglutinin disease

Answer 5

IgM aggregates, Type 2

Question 6

Warm Agglutinins Disease

Answer 6

IgG aggregates (internal body temp)

Type 2

Question 7

drug induced hemolytic anemia

Answer 7

type 2

Question 8

pernicious anemia

Answer 8

type 2

Question 9

good pastures syndrome

Answer 9

type 2
antibody against GBM (glomerular basement membrane) followed by recruitment of PMNs, and NET which damages
tissues

Question 10

pancreatitis

Answer 10

antibody against islet cells

type 2

Question 11

rheumatic fever

Answer 11

strep antibody against heart

type 2

Question 12

thyroiditis

Answer 12

type 2

antibody against thyroglobulin

Question 13

pemphigoid

Answer 13

type 2

skin basement membrane

Question 14

primary biliary cirrhosis

Answer 14

type 2

mitochondria ; not disease causing

Question 15

Sjorgen Syndrome

Answer 15

type 2

salivary glands

Question 16

myasthenia gravis

Answer 16

acetylcholine receptor

Question 17

graves’ disease

Answer 17

hyperthyroidism, acts like TSH

type 2

Question 18

cryoglobulin vasculitis, raynauds

Answer 18

type 3

IgM aggregates

Question 19

hypersensitive allergic pneumonitis

Answer 19

type 3
starts of as th2 disease
can turn into type 4 granuloma bc organisms have intracellular phase,

Question 20

lupus

Answer 20

type 3

Question 21

CIC mediated glomerulonephritus

Answer 21

type 3
cic non-specifically deposits on GBM of kidney

different than good pasteurs syndrome

Question 22

farmers lung

Answer 22

can be type 3

Question 23

rheumatoid arthritis

Answer 23

type 3

IgM against IgG

Question 24

chronic hepatitis

Answer 24

type 3

persistent viral antigen( liver damage impedes CIC clearance)

Question 25

alcoholic cirrhosis

Answer 25

liver damage and impedes cic clearance type 3

Question 26

serum sickness

Answer 26

type 3

Question 27

anaphylaxis

Answer 27

can be type 1 or 3 occurs when sensitized individual is re-exposed to antigen if the individual is atopic, type 1 reaction ...antigen has direct access to circulation causing IgE and histamine release) type 3 competent causes histamine r lease

Question 28

major players in type 2 and type 3

Answer 28

``` c3b c3a c5a PMNs lysis ```

Question 29

skin testing

Answer 29

type 4 details if individual precious encountered antigen or immune competency of suppressed people

Question 30

causes of granulomas

Answer 30

can be infections (tb, mumps, leprosy) or non infections (wood, glass, metals, dust)

Question 31

irritant contact dermatitis allergic contact dermatitis

Answer 31

type 4 differentiate by T cell involvement/activation (only in allergic) via elispot assay or patch test

Question 32

scratch test | patch test

Answer 32

scratch used for type 1 (minutes) patch used for type 2 (days)

Question 33

why no antibody response in type 4 allergic contact dermatitis

Answer 33

no free antigen it’s a chemical, cause hapten formation but no free antigen for sIg to bind

Question 34

well demarcated lesions

Answer 34

type 4

Question 35

t/f little to no mast cell activation in type IV acute contact dermatitis

Answer 35

true also not much complement histamine release from complement binding mast cell in type 3 and 2 though treat by removing offending agent or topical anti inflammatory

Question 36

``` type IV a b c d ```

Answer 36

a: th1 cells recruit and activate macrophages...contact dermatitis b: eosiniphils cause asthma c: cd8 can cause contact contact dermatitis by hapten on MHC1 d: neutrophils , Behcet disease

Question 37

formaldehyde

Answer 37

type 4

Question 38

nickel

Answer 38

type 4

Question 39

how can you inherit allergies

Answer 39

leaky gap junctions, genes mhc haplotype parents have allergies

Question 40

non inherited characteristics of allergies

Answer 40

class switch from igg to ige , using il4 and il13 cytokines b cell with il4 and il13 receptors iga deficiency (allows allergens to bypass mucusol surfaces) presence and reactivity of Tregs (release il10 which prevents class switch) environment

Question 41

anaphylaxis

Answer 41

constriction of bronchial tubes , sometimes rash and fever , life threatening caused by histamine release from mast cells either by IgE binding (1) or C3a and C5a binding (3)

Question 42

wheal and flare

Answer 42

``` type 1 type 3 (from histamine release from mast cells via complement) ```

Question 43

allergic rhinitis

Answer 43

inflammation of the eye nose or throat

Question 44

c3 convertase

Answer 44

C3bBbP C1C2bC4b

Question 45

mutations in C1 inhibitor can cause

Answer 45

vasodilation bc too much C3a and C5a

Question 46

pleiotropic cytokine

Answer 46

IL4 class switch macrophage inhibitor t cell growth factor

Question 47

redundant cytokines

Answer 47

il4 il5 il2 b cell proliferation

Question 48

antagonistic cytokines

Answer 48

``` Il10 and IL4 perfect class switch ``` IFNy and Il10 macrophage activator and inhibitor

Question 49

autocrine cytokines

Answer 49

il2

Question 50

endocrine cytokine

Answer 50

IL1

Question 51

paracrine cytokine

Answer 51

IL 4 from t cell causes adjacent b cell to class switch

Question 52

how many types of cytokine receptor families

Answer 52

i i iii iv

Question 53

type and type ii property

Answer 53

have separating binding and signaling domain

Question 54

IL2 low intermediate and high

Answer 54

a by aby

Question 55

anakinra

Answer 55

receptor agonist

Question 56

entanercept and infliximab

Answer 56

tnf soluble receptor

Question 57

clinical uses of GM-CSF

Answer 57

bone marrow transplant cytopenias

Question 58

EPO

Answer 58

kidney dialysis | anemia from chemo

Question 59

cytokines clinically used for cancer

Answer 59

ifn-a

Question 60

cytokines clinically used to viral therapy like hep b and c

Answer 60

if a

Question 61

integrins function

Answer 61

cell cell | cell ecm interactions

Question 62

chemokines act via what receptor

Answer 62

g coupled protein

Question 63

chemokines jobs

Answer 63

chemotaxis degranulation angiogenesis