test 2 lec 3

Question 1

test 2 lec 3

name 4 different type of VDKC

Answer 1

Ia, Id,Ik,Im

Question 2

test 2 lec 3

which one of the VDKC are LVA?

Answer 2

Ia, Id,Im

Question 3

test 2 lec 3

which VDKC activate and inactivate rapidly?

Answer 3

Ia

Question 4

test 2 lec 3

which one of the VDKC is medium inactivating?

Answer 4

Id

Question 5

test 2 lec 3

which on of the VDKC is activated while the Na+ channels are activated?

Answer 5

Ia,Id

Question 6

test 2 lec 3

which one of the VDKC is considerd HVA? It is slow of fast inactivating?

Answer 6

Ik, slow inactivating

Question 7

test 2 lec 3

how long does Ik stay active?

Answer 7

as long as the membrane potential is strongly depolarized,

Question 8

test 2 lec 3

what is the function of Ik?

Answer 8

to bring the membrane potential back down in the resting potential taneg

Question 9

test 2 lec 3

how does Ik inactivate?

Answer 9

they help create condition that inactivate them , by bringing the membrane potentail near resting potential

Question 10

test 2 lec 3

which one of the VDKC in considered non-inactivating?

Answer 10

Im

Question 11

test 2 lec 3

which one of the VDKC is not inactivated by voltage change?

Answer 11

Im

Question 12

test 2 lec 3

which is the effect of voltage on Ik after its being activated?

Answer 12

nothing

Question 13

test 2 lec 3

which ion can block all kinds of VDKC?

Answer 13

Cs

Question 14

test 2 lec 3

which of the VDKC are blcoked by DTX?

Answer 14

Ia, Id, Ik

Question 15

test 2 lec 3

which one of the VDKC is activated by Retigabine?

Answer 15

Ia and Im

Question 16

test 2 lec 3

which is the ingridient that help reverse male-pattern baldness and what does it do?

Answer 16

Minoxidil and it activates the Id VDKC

Question 17

test 2 lec 3

which one of the VDKC are activated by adding a sugar to the extracellular side of it?

Answer 17

Ik,

Question 18

test 2 lec 3

how is Ik activated

Answer 18

by Glycosylation

Question 19

test 2 lec 3

which one of the VDKC is not blocked by DTX?

Answer 19

Im

Question 20

test 2 lec 3

which one of the VDKC is blocked by DTX?

Answer 20

Ia,Id,Ik

Question 21

test 2 lec 3

which scorpian toxin blocks VDKC Ia,Id,Ik?

Answer 21

DTX (dendrotoxin)

Question 22

test 2 lec 3

which drug blocks the fast , slow and medium inactivation VDKC?

Answer 22

TEA, 4-AP (4-aminoperidine)

Question 23

test 2 lec 3

which VDKC is blocked by TEA?

Answer 23

Ia,Id,Ik

Question 24

test 2 lec 3

which drug can activate Id?

Answer 24

Minoxidil

Question 25

# test 2 lec 3 what drug can activate Ia and Im?

Answer 25

retigabine

Question 26

# test 2 lec 3 what are the 2 drug that only blockes Im?

Answer 26

Linopiridine, muscarinic agonist

Question 27

# test 2 lec 3 which potassium channel is HVA and SI?

Answer 27

Ik

Question 28

# test 2 lec 3 whatmechanism is responsible for activation of VDKC?

Answer 28

Voltage-dependent conformational movement of negatively charged portions of the alpha subunits activate K influx

Question 29

# test 2 lec 3 which subunit of VDKC is responsible for the K influx?

Answer 29

alpha subunit

Question 30

# test 2 lec 3 which subunit is responsible for inactivation of VDKC?

Answer 30

Beta subunit which is inside the membrane

Question 31

# test 2 lec 3 how does B-subunit blockes the VDKC?

Answer 31

Inactivation involves voltage-dependent binding of any 1 of 4 positively charged _ball and chain_ portions of beta subunits to block K influx

Question 32

# test 2 lec 3 which one of the VDKC lacks B-subunit?

Answer 32

Im which is the non-inactivating one

Question 33

# test 2 lec 3 why is Im VDKC in called non-inactivating?

Answer 33

because it lacks B-subunit

Question 34

# test 2 lec 3 what is the Anomalous and Ih rectifier K channel made of?

Answer 34

4 seperated subunit with 2 Transmembrane segment each

Question 35

# test 2 lec 3 what is the structural difference of the tandom channel eith other VDKC?

Answer 35

4 different sets of subunits with 4 transmembrane segments each, dimerize (2 sets of 4) to yield a single protein with 2 pores

Question 36

# test 2 lec 3 which potassium channel is considered both rectifying and VDKC?

Answer 36

Ik

Question 37

# test 2 lec 3 how does Ik activates?

Answer 37

activate when membrane is depolarized, and it is a HVA channel

Question 38

# test 2 lec 3 which one of the Rectifying channel is Slow inactivating?

Answer 38

all of them, Ik, HA and Anomalous, Ih, tandom pore

Question 39

# test 2 lec 3 which one of the Rectifying channel has no known blocker?

Answer 39

Tandom pore

Question 40

# test 2 lec 3 how does anomalous and IH channels are activated?

Answer 40

they are hyperpolarization activated

Question 41

# test 2 lec 3 what does anomalous and Ih channel do to the membrane potential?

Answer 41

they bring the membrane back to the resting potential by generating the inward K+ current

Question 42

# test 2 lec 3 how does the 2 activators of Tandom pore?

Answer 42

Halothane and Isoflurane, they recryfie the membrane potential, they bring it down to resting potential ,explain how local anesthetics work

Question 43

# test 2 lec 3 does changing the membrane voltage affect the activation of tandom pore?

Answer 43

no

Question 44

# test 2 lec 3 what is the effect of voltage change on tandom pore?

Answer 44

They are not affected by voltage

Question 45

# test 2 lec 3 what is the side effect of the chronic exposure to the Halothane?

Answer 45

they cause sever liver damage to the people who is in operating room that is exposed in daily bases

Question 46

# test 2 lec 3 what decreases the current flow in Metabotropic-gated channels ?

Answer 46

kinase's activity (phosphorylation) decrease theoutward current to Metabotropic-gated channels

Question 47

# test 2 lec 3 what process can increase the current flow of Metabotropic-gated channels ?

Answer 47

phosphatases can increase the current flow to thoes channels.

Question 48

# test 2 lec 3 what are the four types of Metabotropic-gated channels?

Answer 48

Im,Iatp,Iahp,Isahp

Question 49

# test 2 lec 3 Metabotropic-gated channels are activated by:

Answer 49

they tight to ion channel which are activated indirectly by binding of ligand to receptor and binding of inactive G-protein to thoes receptor and then the exchange of GTP for GDP then the dissociation of alpha and beta-gamma subunit then _.. Read the process of G-protein life cycle

Question 50

# test 2 lec 3 what kinase is activated by CAMP?

Answer 50

PKA, it takes 4 CAMP to fully activates it, then that kinase can phosphorylate protein including these channels and inactivate them and decrease the flow of current.