test 3. 6 gastric dis Flashcards
3 types of gastric parietal cell receptors
how does stomach cells protect themselves from acid
- mucus has bicarb that keeps around pH7
- cells have intracellular bicarb
- adaptive cytoprotection where they will increase prostaglandins if exposed to acid
- fast cell turnover
- increased blood flow
4 areas that control vomiting
CRTZ is outside BBB- effected by things in the blood
FB in proximal GI tract will cause
hypochloremic metabolic alkalosis
* from vomiting out all the HCl
gastric tumor types for dogs and cats
cat: lymphoma
dog: adenocarcinoma
antral pyloric hypertrophy presents as
chronic vomiting which worsens with time- can be projectile
- congential- boxers bostons, young to middle age
- acquires- older small male- maltese, shih tzu
surgery- excellent prognosis
pythiosis is caused by
fungus like- pythium insidiosum
* found in stagnant water in southeast US
* form granulomas that can cause obstruction
* hard to resect- poor prognosis
how do NSAIDs cause gastric ulcer
COX2 and COX1- prostaglandins
how do mast cells cause gastric ulcer
release histamine which bind to H2 receptor on parietal cell and increase HCl production
how does addisions cause ulcers
decrease in mucosal blood flow= less bicarb brought to the cells= more acid
— are proton pump inhibitors
omeperazole, pantoprazole
- blocks the H/K ATPase pump on the parietal cell- prevents the release of H into the stomach= Hcl can not be formed
— can be used to protect against gastric ulcer form NSAID use
misoprostol - synthetic prostaglandin
when to do surgery for gastric ulcer
gastric perf
too much blood loss
medical treatment not working
what are some causes of functional delayed gastric emptying
- infiltrative/inflammatory disease: lymphoma, IBD
- electrolyte abnormalities
- drugs: opiods, anticholingergics
- idiopathic
