Test Flashcards
(36 cards)
1
Q
How many patients are needed for a phase 1 drug trial?
A
20-100, healthy males
2
Q
How many patients are needed for a phase 2 drug trial?
A
100-300, have disease
3
Q
How many patients are needed for a phase 3 drug trial?
A
1000-3000 pts, does drug work better than something else
4
Q
What determines if a drug is bioequivalent?
A
Rate of absorption, extent of absorption
5
Q
How much is 1 grain?
A
65mg
6
Q
How much is 1oz in g?
A
30g
7
Q
How much is 1kg in lbs?
A
2.2lbs
8
Q
How many liters in a gallon?
A
3.785L
9
Q
qam
A
Every morning
10
Q
prn
A
When needed
11
Q
pc
A
After meals
12
Q
hs
A
At bedtime
13
Q
bid
A
Twice a day
14
Q
ac
A
Before meals
15
Q
stat
A
Immeadiately
16
Q
tid
A
3 times a day
17
Q
IA
A
Intra-arterial
18
Q
IM
A
Intramuscular
19
Q
IV
A
Intravenous
20
Q
IVPB
A
IV piggyback
21
Q
po
A
Orally
22
Q
pr
A
Rectally
23
Q
sc-sq
A
Subcutaneous
24
Q
vag
A
Vaginally
25
The route of drug administration is an important variable in determining what?
F, rate of onset of drug effect, duration of drug action
26
What effect does increased GI motility have on the rate of absorption?
Increases rate of absorption
27
Aside from the liver, what organ is the next biggest drug metabolizer?
Lung
28
Omeprazole, enalapril, and valacyclovir are all similar in what way?
They are inactive compounds that are metabolized to active drugs
29
Is phase 1 or phase 2 metabolism more easily induced/inhibitable?
Phase 1
30
Does Phase 1 or Phase 2 metabolism have more genetic variability?
Equal
31
What acronym are you going to use for inducers?
PCR STEP
32
What are inducers of drug metabolism?
Phenytoin, carbamazepine, rifampin, st johns work, tobacco, ethanol, phenobarbital
33
What acronym are you going to use for inhibitors?
CASE HOG
34
What are inhibitors of drug metabolism?
Cimetidine, azole antifungals, SSRIs, erythrromycin, HIV protease inhibitors, omeprazole, grapefruit juice
35
When are the maximal effect of enyzme induction seen?
7-10 days
36
What is the effect of rifampin on OCs?
Decreased OC plasma concentration
