test 4

Question 1

temporal arteritis

Answer 1

inflammation and damage to the blood vessels that supply blood to the head; unknown cause;
feel a string like a pencil

Question 2

giant cell arteritis.

Answer 2

temporal-if the inflammation affects the arteries in your neck, upper body and arms, it is called

Question 3

immune system related diseases

Answer 3

autoimmune disease
hypersensitivity disorders (allrgis)
immunodeficencies
neoplasia (leukemias, lyphomoas, others)

Question 4

autoimmune disease

Answer 4

caused y erroneous attack of the immune system on SELF tissues

dont know most pathogenesis

Question 5

exs of autoimmune disease

Answer 5

rheumatoid arthritis
multiple sclerosis
type 1 diabetes
graves disease
mayasthenia gravis

Question 6

Autoimmunity

Answer 6

Immune responses directed against self antigens (self tissues). Does not necessarily lead to tissue damage

Question 7

Autoimmune disease

Answer 7

An inappropriate response of the immune system against self antigens which results in tissue damage

Question 8

B cells can produce

Answer 8

autantiobodies

Question 9

T cells can produce

Answer 9

autoantigens

Question 10

mechanisms to control autoimmunity 1

Answer 10

most autoantibodies are IgM with low affinity and are present in low concentrations. IgM antibodies remain intravascular

Question 11

mechanisms to control autoimmunity 2

Answer 11

autoantigens are often sequestered

Question 12

mechanisms to control autoimmunity 3

Answer 12

autoreactive t cells are deleted in thymus (neg selection) or in periphery (lack of costimulation, periphereal toleracne)

Question 13

mechanisms to control autoimmunity 4

Answer 13

autoreactive b cells are deleted in bone marrow

Question 14

mechanisms to control autoimmunity 5

Answer 14

autoreactive t cells need to be activated before they can do damage; they need to see their target in antigen presenting cells and need to get the right signasl to become harmless

Question 15

mechanisms to control autoimmunity 6

Answer 15

regulatory cells may control autorective cells

Question 16

Molecular mimicry

Answer 16

Sequence homology between microbial and self proteins. Immune system responds to microbes and cross-reactive autoimmunity to self-antigens develops.example: RHEUMATIC FEVER

Question 17

Failure of regulatory mechanisms:

Answer 17

failure of tolerance, lack of regulatory T cells, cytokine imbalances

Question 18

how do autoimmune diseases arise?

Answer 18

M.F.P.A.

Question 19

t cells mature and educated in

Answer 19

thymus

Question 20

genes and autoimmune disease

Answer 20

HLA(MHC) is the strongest link

Question 21

organ specific autoimmune disease

Answer 21

targets a specific organ

antibody mediated organ specific autoimmune disease

cell-mediated organ specific autoimmune diseases

Question 22

antibody mediated organ specific autoimmune diseases

Answer 22

Grave’s diease
Myasthenia gravis
Goodpasture’s syndrome

Question 23

cell mediated organ specific autoimmune disease

Answer 23

multiple sclerosis

type 1 disease

Question 24

systemic autoimmune disease

Answer 24

systemic lupus erthematosus

rheumatoid arthritis

Question 25

classification of autoimmune disease

Answer 25

organ specific (antibody or cell mediated ) auto immune dsease and systemic autoimmune diseases

Question 26

graves disease

Answer 26

stimulating autoantibodies

Question 27

Myasthenia gravis

Answer 27

blocking autoantibodies

Question 28

Good pasture's syndrome

Answer 28

destructive autoantibodies

Question 29

Graves' (Basedow) disease

Answer 29

production of autoantiobies agianst the TSH receptor. Binding of it mimics effect of TSH ad stimulates thyroid gland with release of high levels of thyroid hormones in the blood.