test 7 prostacyclin analogues Flashcards
1
Q
Prostacyclin mechanism of action
A
- PGI2 attaches to the G-protein and activates it
- signals adenylyl cyclase to produce cAMP
- cAMP goes on to activate protein kinase
- results in smooth muscle relaxation
2
Q
Epoprostenol (Flolan)
A
o PGI2 analogue
o It is a potent vasodilator used for pulmonary hypertension. Mimics prostacyclin from endothelial cells; decreases resistance to blood flow and increases oxygen delivery. Given by IV route.
