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Testing Flashcards

(12 cards)

0
Q

Species of choice for repro tox tests

A

Rats

Lesser degree mice

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1
Q

What are the three Rs in animal testing

A

Replace
Reduce
Refine

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2
Q

Female repro test end points

A

Tract morph and receptors, ovum properties, blastocyst recovery,
Hormonal balance/receptor, cycle length/normalcy, fertility, uterine
Condition, implantation, lactation, maternal behavior

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3
Q

Male repro end points

A

Sperm structure and morph, sperm motility viability and count
Sperm DNA integrity, hormonal balance and receptor interaction
Fertility

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4
Q

What is the most important period for developmental tox tests

A

Organogenesis

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5
Q

Most dev tox test are done in what

A

Rat. However the rat plus rabbit is better. If get a neg test in rat go to rabbit to catch the ones the rat misses.

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6
Q

What is the model of choice for cutaneous testing

A

Until recently the albino rabbit however it was too sensitive and over predicted so now the albino rat and sometimes Guinea pigs are used.
When a non rodent is needed the mini pig is choice.
Sensitization is guinea pig

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7
Q

What does mouse spot test detect

A

Somatic gene mutation by alter coat color (colored spots)

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8
Q

What is the model for neuro tox tests

A

The rat. However, dogs guinea pigs and mini pigs are also used esp. For children comparison.

Rat has brain develop after birth that others do not a major disadvantage

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9
Q

What r the main transgenic systems used

A

Muta mouse lacZ

Big blue rat/mouse lacI

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10
Q

Advantages and disadvantages of in vitro

A

Adv. inexpensive,easy to maintain and manipulate, study direct cell effects in controlled environment

Disadv. Lack systemic effects EG. Growth factors, metabolism elimination, cell cell interaction

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11
Q

In vitro test should have end points that

A

Show dose response relationship
Are predictive of in vino pattern
Are objective and reproducible
Have internal controls

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