The Case of the Swollen Belly Flashcards

(52 cards)

1
Q

5 F’s of enlarged abdomen

A
fluid
flatus (obstruction)
faeces
fat 
foetus
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2
Q

caput medusae

A

swollen abdo wall veins due to portal hypertension

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3
Q

abdominal paracentesis

A

puncture of the abdomen for aspiration of fluid in the peritoneal cavity

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4
Q

how much fluid filtered into large body cavities per day?

A

how much fluid filtered into large body cavities per day?

20L

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5
Q

how much fluid is reabsorbed back into circulation?

A

how much fluid is reabsorbed back into circulation?

90%, rest returns as lymph fluid

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6
Q

why does fluid leave capillaries?

A

high pressure pushes fluid into interstitial space

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7
Q

why does fluid reenter venous circulation?

A

low pressure causes reabsorption

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8
Q

what 4 things affect Qf/filtration/reabsorption rate of fluid?

A

change in hydrostatic pressure
change in oncotic pressure
change in permeability
change in exchange area

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9
Q

Where are serous membranes located?

A

pericardium
pleura
peritoneum
tunica vaginalis of testis

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10
Q

are effusions always pathological?

A

yes, but only clinically detectable once a certain size

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11
Q

transudate

A

plasma filtrate forced into tissues, low protein content

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12
Q

what causes transudate?

A

↑ Hydrostatic pressure
or
↓ Oncotic pressure

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13
Q

what causes exudate?

A

increased vascular permeability, change in exchange area

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14
Q

exudate

A

unfiltered plasma with high protein content

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15
Q

what causes hydrostatic pressure change?

A

portal hypertension

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16
Q

what causes 80% of portal hypertension?

A

liver cirrhosis

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17
Q

Other causes of portal hypertension (aside from liver cirrhosis)

A

alcoholic hepatitis

chronic cardiac failure

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18
Q

what causes oncotic pressure change?

A

hypoalbuminuria (caused by nephrotic syndrome, malnutrition, protein losing enteropathy)

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19
Q

what affects exchange area or vascular permeability?

A

malignancy, infection

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20
Q

Serum Albumin Ascites Gradient (SAAG)

A

a value which suggests portal hypertension if >1.1g/dl, if lower not portal hypertension

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21
Q

diagnostic technique for ascites

A

ascitic aspiration

22
Q

risk of ascitic drainage (5)

A
bleeding
infection
pain
leakage at drainage site
procedure failure
23
Q

Seldinger technique

A

A technique that involves inserting a needle with a syringe, then inserting a guide wire into the needle, removing the needle, making an incision, and inserting a catheter over the guide wire; the guide wire is then removed

24
Q

what does pale yellow watery fluid aspirated suggest?

A

transudate

Low protein

25
what does brown aspirated fluid suggest?
haemorrhage
26
what does turbid and white/yellow aspirated fluid suggest?
infection or malignancy
27
what does green aspirated fluid suggest?
bile
28
what cells might be present in effusions?
``` mesothelial cells macrophages lymphocytes neutrophils eosinophils plasma cells artefacts ```
29
Ferruginous bodies
asbestos fibers coated with iron, usually seen trying to be absorbed by 2 macrophages
30
what do lupus cells look like morphologically?
what do lupus cells look like morphologically? | large macrophages with an engulfed nucleus
31
what does lymphocytes all at same stage of maturation in an effusion suggest?
lymphoma
32
Features of mesothelioma
DIFFUSE nodular pleural thickening (not discrete) Often unilateral Thickening of fissures
33
DIFFUSE nodular pleural thickening (not discrete) Often unilateral Thickening of fissures = features of…
Features of mesothelioma
34
melanoma markers
S-100, HMB-45, melan A, SOX-10
35
small cell carcinoma of the lung markers
Napsin A, TTF-1
36
what is seen on doppler US in portal hypertension?
reversal of flow in portal vein
37
issues with iodine contrast for CT
can cause allergic reactions | contrast induced nephropathy
38
fine needle aspiration (FNA)
biopsy technique that uses a narrow hollow needle to obtain tiny amounts of tissue for pathologic examination
39
benefits of FNA
outpatient, minimal discomfort rapid results excellent cell preservation
40
2 ways of fixing cytology samples
air dry | alcohol fixation
41
can you use formalin in cytology
no destroys the cells
42
Cytospin
- cytological technique specifically designed to concentrate cells on a slide in a uniform monolayer using high speed centrifuge. The monolayer distribution improves the morphological appearance of the cell present
43
3 causes of lymph node enlargement
reactive lymphadenitis, metastatic malignancy, lymphoma
44
causes of reactive lymphadenopathy (5)
``` HIV mononucleosis SLE RA syphilis ```
45
causes of granulomatous lymphadenitis
``` TB cat scratch disease leprosy silica lymphoma sarcoid ```
46
breast adenocarcinoma cytology
diffuse cell pattern | proliferation spheres
47
stomach adenocarcinoma cytology
signet ring cells | dispersed single cells
48
lung adenocarcinoma cytology
highly vacuolated papillary groups dense cytoplasm
49
Colorectal Adenocarcinoma cytology
tall columnar cells | nuclear palisading
50
features of air dried slide samples
cytoplasmic features visible | metachromasia
51
features of fixed slide samples
features of fixed slide samples transparent nuclear detail and keratinisation hyperchromasia
52
hyperchromasia
abundant DNA, extremely dark staining