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Flashcards in The "-ITIS" Lecture Deck (21)
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1
Q

Describe 3 classic symptoms of esophagitis.

A
  1. “Indigestion” and chest discomfort
  2. Frequent Heartburn
  3. “Food sticking” in the chest not going down into the stomach (Dysphagia).
2
Q

Why might a patient with chronic esophagitis have microcytic anemia and low iron? What are some ways to manage this?

A

Long-standing esophagitis can result in inflammation and bleeding resulting in mild anemia.

  1. Use of a PPI can shut down H+ secretion to prevent further aggravation of inflammation.
  2. Dietary changes such as abstaining from caffeine and eating before bed might help too.
3
Q

What 2 other differential diagnoses are often associated with esophagitis for a middle-aged man, with a sedentary life-style, a FH of heart issues and GERD?

A
  1. Coronary artery disease (often mimicks GERD symptoms)

2. Esophageal stricture/malignancy (dysphagia alarm symptom)

4
Q

What is the purpose of a stress thallium test? Describe how it works.

A

This is to evaluate if someone has an occlusion to the heart while running on a treadmill. Inject someone with nuclear material and scan to see if there’s a ring. If there is not, there may be some non-perfused cardiac tissue.

5
Q

Define the pathophysiology of Gastroesophageal Reflux Disease.

A

GERD is an issue with the lower esophageal sphincter (LES) that is not closed properly increasing the incidence of gastric reflux. The right crux of the diaphragm plays a major role in closure of LES.

6
Q

What is a hiatal hernia?

A

Hiatal hernia is the pouching of stomach up through the diaphragm and into the chest. This results in the loss of the ability to keep the sphincter tight.

7
Q

List at least 3 major factors that lead to GERD.

A
  1. Descreased LES resting pressure (abnormal tone and relaxation).
  2. Hiatal Hernia
  3. Impaired distal esophageal mucosal defense.
8
Q

Describe what a gastroenterologist might do to deal with an esophageal stricture.

A

Put a balloon down the esophagus to dilate (blow-up) the stricture as an intervention for dysphagia.

9
Q

Describe the clinical significance of Barrett’s Esophagus. What might a patient with this condition be at risk of developing?

A

Barrett’s esophagus is the onset of intestinal metaplasia in the esophagus. This is the replacement of squamous epithelium with columnar (intestinal) epithelium as a defense mechanism. This can progress towards a carcinoma if development becomes dysplastic.

10
Q

What are the 3 alarm symptoms of esophagitis, that can be detected from endoscopy?

A
  1. Dysphagia
  2. Bleeding resulting in mild anemia.
  3. Weight loss
11
Q

Name 3 or more clinical signs/symptoms of Acute cholecystitis.

A
  1. Positive + Murphy’s Sign (tenderness @ RUQ upon inspiration)
  2. Elevated triglycerides and WBC count
  3. Nausea/ vomiting
12
Q

What are the factors that distinguishes Biliary Colic form Acute Cholecystitis?

A
  1. RUQ pain lasting less than 4 hours (goes away)
  2. Stone lodged in cystic duct can fall out, relieving the patient.
  3. Radiation of epigastric pain
13
Q

A closeup of the crystals in the gallstone of someone with Acute Cholecystitis would indicate what?

A

Lithogenic (rock-like) bile and cholesterol crystals “shaped like the state of Utah”.

14
Q

Describe the changes in morphology of the gallbladder in Acute Cholecystitis.

A

Thickened wall of gall bladder that has poor contractility, chronic inflammation, stone lodged in cystic duct

15
Q

About ____% of the time, the cystic duct can be obstructed by a gallstone. Whereas, about ___% of the time, acute cholecystitis is ________.

A

90% of cholecystitis is due to an obstruction of cystic duct.
10% of cholecystitis cases are acalculous (no gallstones)

16
Q

Some prominent risk factors (name 5) for Acute Cholecystitis include:

A
  1. Diabetes + high triglycerides
  2. Pregnancy (high estrogen = high cholesterol)
  3. Family history increasing risk of occurence
  4. Rapid weight loss diets
  5. Cirrhosis (decreased bile salt production)
17
Q

Why would a patient with Acute Cholecystitis have elevated transaminases?

A

Inflammed gallbladder sits in the fossa below the liver. This inflammation can spread to the liver causes elevation of LFT’s.

18
Q

What is the BEST treatment for someone with Acute Cholecystitis? Why?

A

Removal of the gallbladder (Cholecystectomy) is teh best treatment for patients, given they lower their fat intake. We can live well without a gallbladder.

19
Q

What are the 4 clinical signs/symptoms associated with Acute Pancreatitis?

A
  1. Epigastric pain
  2. Vomiting and dehydration (high BUN)
  3. Elevated WBC counts
  4. > 3x normal amylase and lipase lab values.
20
Q

Describe the main causes and pathophysiology of Acute Pancreatitis.

A

90% of the time caused by Alcohol (toxin) or Cholelithiasis (gallstones in Sphincter of Oddi). Auto-digestion of pancreas can occur from inappropriately activated pancreatic enzymes resulting in edema and inflammation.

21
Q

What are the 3 best treatments for Acute Pancreatitis?

A
  1. Gut rest/ IV support = stop the patient from eating and provide supportive care
  2. Removal of gallbladder for gallstone-induced pancreatitis.
  3. Alteration of life style and nutrition (lower fat intake)