The NRC Guide

Question 1

T/F At Least one of the IACUC Members must be a qualified veterinarian.

Answer 1

True

Question 2

How often should an IACUC inspect a facility?

Answer 2

At least once every 6 months

Question 3

Animal should be housed with a goal of maximizing ____ behavior and minimizing ____ behavior.

Answer 3

species-specific; stress-induced

Question 4

T/F Personnel are permitted to eat or drink in the animal rooms as long as proper ppe is being used.

Answer 4

False

Question 5

Name a special PPE requirement for people working in noisy areas.

Answer 5

hearing protection\ear plugs

Question 6

T/F A regularly scheduled program of pest control and monitoring is required in animal facilities.

Answer 6

True

Question 7

T/F In the Guide, the word “should” is used to express a strong recommendation for achieving a goal.

Answer 7

True

Question 8

Why is it recommended that nonhuman primates, dogs, and cats be group housed?

Answer 8

Because they are social animals

Question 9

How many hourly room changes does the Guide recommend in an animal room?

Answer 9

10 - 15

Question 10

Tuberculosis and B virus infection are examples of _____ diseases that necessitate specific guidelines in the handling of nonhuman primates

Answer 10

zoonotic

Question 11

T/F Cat cages should be 12 inches high.

Answer 11

False

Question 12

HEPA is the acronym for _________.

Answer 12

High Efficiency Particulate Air

Question 13

Would is be acceptable for the animal facility secretary to serve on the IACUC as the public member?

Answer 13

No

Question 14

If social animals must be housed alone, other forms of _____ should be provided.

Answer 14

enrichment

Question 15

If floor drains are present in animal rooms, the drainpipes should be at least ______ inches in diameter.

Answer 15

4

Question 16

High levels of repetitive, unvarying behavior in laboratory animals are know as ________.

Answer 16

stereotypies

Question 17

How does the *Guide *define major surgery?

Answer 17

Penetrates and exposes a body cavity or produces substantial impairment of physical or physiological function or involves extensive tissue dissection or transection

Question 18

Name three benefits of group- or pair-housing conspecifics.

Answer 18

Essential for normal development in many species; companion might buffer the effects of a stressful situation; reduce behavioral abnormalities; increase opportunities for exercise; expand species-typical behavior and cognitive stimulation

Question 19

For species that produce urine with high concentrations of minerals, cage surface must be treated with what type of chemical before washing?

Answer 19

acid solution

Question 20

The physical environment immediately surrounding an animal is called its ______.

Answer 20

microenvironment

Question 21

The IACUC must ensure compliance with the guidelines and regulations found in _______, ________, and _________.

Answer 21

the Guide; the Animal Welfare Regulations; the PHS Policy

Question 22

A diet with non-stabilized vitamin C has a shelf life of only ______ months.

Answer 22

3

Question 23

T/F An occupational health and safety program is not required as part of the overall animal care and use program.

Answer 23

False

Question 24

T/F Newly received animals do not need a stabilization period, but larger animals due.

Answer 24

False

Question 25

If animals are placed on restricted fluids for a study, what monitoring procedures are necessary?

Answer 25

Daily monitoring for the animal's fluid intake, hydration status, and body condition. Depending on the species, it may be necessary to weigh the animal weekly or more frequently.

Question 26

T/F The* Guide* recommends that animal technicians should be responsible for laundering the clothing they wear in the animal facility.

Answer 26

False

Question 27

T/F Technicians working with macaques should have access to bite and scratch emergency care stations.

Answer 27

True

Question 28

T/F The *Guide* recommends the used of chemicals designed to mask animal odors in animal rooms.

Answer 28

False

Question 29

What type of animals are particularly susceptible to phototoxic retinopathy?

Answer 29

Albino rodents

Question 30

T/F A table in the *Guide* shows how often bedding should be changed for rodents

Answer 30

False

Question 31

Most animal food can be used up to about ____ months after manufacture.

Answer 31

6

Question 32

T/F Although the *Guide* recommends that animal rooms have a regular light/dark cycle, it does not recommned the use of a time-controlled lighting system.

Answer 32

False

Question 33

What is the acceptable range of relative humidity in an animal room?

Answer 33

30% - 70%

Question 34

T/F The *Guide* does not address the issue of staff training.

Answer 34

False

Question 35

According to the *Guide*, who is ultimately responsible for the animal care and use program

Answer 35

The Instiutional Offical

Question 36

What is the acceptable general standard of air changes per hour in a secondary enclosure?

Answer 36

10 - 15

Question 37

The period of restraint of any animal should be the ____ required to accomplish the research objectives.

Answer 37

minimum

Question 38

What is the recommended practice for storing feed and bedding?

Answer 38

Off the floor on pallets, racks, or carts | USDA also requires that feed bags be stored away from contact with walls

Question 39

T/F Toe-clipping is the preferred method of identification for small rodents.

Answer 39

False

Question 40

Standard laboratory animal diets can be stored for 6 months after milling date except for diets that contain __________.

Answer 40

Vitamin C

Question 41

T/F The HVAC system should be capable of adjusting dry-bulb temperature by +/- 2 ^oF (+/- 1 ^oC)

Answer 41

True

Question 42

How often should watering devices be checked?

Answer 42

Daily

Question 43

T/F Chemicals can be used to disinfect primary enclosures.

Answer 43

True

Question 44

An animal housed in a stall inside of a barn. What would be considered the primary enclosure for this animal?

Answer 44

The stall

Question 45

Assessing the health status of animals in the research program is the responsibility of the ______.

Answer 45

Attending Veternarian

Question 46

Who should be identified as the "official responder" for the animal facility in an instiution's disaster plan?

Answer 46

Colony manager or veternarian

Question 47

Unless otherwise justified, methods for euthanasia of animals should be consistent with thte most up-to-date version of the ____ Guidelines for the Euthanasia of Animals.

Answer 47

AVMA

Question 48

Is it correct to assume that the microenvironment of all the animals housed in similar cages in the same room is similar?

Answer 48

No

Question 49

T/F According to the *Guide*, bedding should not be autoclaved.

Answer 49

False

Question 50

The height of a mouse cage should be ____ inches.

Answer 50

at least 5

Question 51

What are the recommended dimesnsions for doors within the animal facility?

Answer 51

at least 42 inches wide by 84 inches high

Question 52

Feed should not be stored at temperatures above ____ ^oF.

Answer 52

70

Question 53

T/F An aseptic surgical suite should include a special room or area for the surgeon to scrub hands and don surgical garb.

Answer 53

True

Question 54

The height of a guinea pig cage should be ________ inches.

Answer 54

at least 7 inches

Question 55

In animal rooms, the relative humidity should be maintained in the ________ to ________ range.

Answer 55

30% to 70%

Question 56

T/F Cage size recommendations in the *Guide* are the same as those in the Animal Welfare regulations.

Answer 56

False

Question 57

T/F Significant saving of staff time is the most usual acceptable justification for the use of restraint devices.

Answer 57

False

Question 58

In general, the *Guide* recommends that animals should not be exposed to temperatures below ____ or above _____.

Answer 58

40^oF (4.4^oC); 85^oF(29.4^oC)

Question 59

What is the difference between experimental and humane endpoints?

Answer 59

Experimental endpoints are when the goals and objectives of the study are reached, humane endpints are when pain or distress in the animal is prevented, terminated, or relieved.

Question 60

The seperation of newly recieved animals from those already in the facility is called ____.

Answer 60

Quarantine

Question 61

Sanitation of an animal cag involves which three tasks?

Answer 61

Bedding change, cleaning, and disinfecting cages

Question 62

T/F The IACUC can approve space allocations that are smaller than those listed in the *Guide*.

Answer 62

True

Question 63

What is the water temperature traditionally required for the final rinse in washing cages?

Answer 63

180^oF(82.2^oC)

Question 64

What type of drug must be used with neuromuscular blocking agents during surgery?

Answer 64

General anesthetic

Question 65

T/F Animal activity typically implies motor activity but also includes social interaction and cognitive activity.

Answer 65

True

Question 66

T/F Photoperiod is a critical regulator of reproductive behavior in many species of animals.

Answer 66

True

Question 67

What is the light level most commonly used in animal rooms?

Answer 67

325 lux (30 foot-candles) about 1 meter above the floor

Question 68

T/f The *Guide* and the Animal Welfare Act Regulations use the same formula to determine minimum floor space caging requirements for dogs.

Answer 68

False

Question 69

Which type of housing is recommended for rodents: cages with wire floors or solid-bottom cages with bedding?

Answer 69

solid-bottom caging with bedding

Question 70

In the United States, responsibilty for reviewing and investigating animal welfare concerns lies with what groups/ and or individuals?

Answer 70

The IO and the IACUC

Question 71

Regardless of quarantine duration, newly recieved animals should be given a period for ____, ____, and ________ stabilization.

Answer 71

physiologic; psychologic; nutritional

Question 72

What is the general purpose for using special cages and ventilation equipment such as filter top cages, ventilated racks, and cubicles?

Answer 72

To minimize the spread of airborne disease agents between cages or groups of cages.

Question 73

Why are cedar shavings not recommended choice for bedding?

Answer 73

They emit aromatic hydrocarbons that induce hepatic microsomal enzymes and cytotoxicity, reported to increase the incidence of cancer

Question 74

T/F Light can affect an animal's physiology, morphology, and behavior.

Answer 74

True

Question 75

For what reasons are animals typically seperated by species, for example in seperate rooms?

Answer 75

To prevent disease transmission between species; to prevent anxiety and stress between incompatible species.

Question 76

T/F Multiple major surgeries on a single animal may be permitted if scientifically justified and approved bt the IACUC.

Answer 76

True

Question 77

T/F Restraint devices may be used as alternative methods of housing animals.

Answer 77

False

Question 78

T/F Negative air pressure in a room is used to prevent the accidental release of infectious agents outside the room.

Answer 78

True

Question 79

T/F Microenviromental conditions can affect the animal metabolically and physiologically and alter the animal's susceptibility to disease.

Answer 79

True

Question 80

Who should review the enrichment program on a regular basis to ensure it is benefical to animal wellbeing and consistent with the goals of animal use?

Answer 80

The IACUC, researchers, and the veternarian

Question 81

What is the responsibility of the IACUC?

Answer 81

Oversight and evaluation of the animal care and use program, procedures, and facilities

Question 82

What is the definition of laboratory animal in the *Guide*?

Answer 82

Any vertebrate animal used in research, teaching, or testing

Question 83

T/F The IACUC is responsible for hiring the animal facility staff.

Answer 83

False

Question 84

What disease should be routinely tested for in people who work near or have contact with nonhuman primates?

Answer 84

Tuberculosis

Question 85

The organization which developed the *Guide for the Care and Use of Laboratory Animals* is ________.

Answer 85

Institute for Laboratory Animal Research (ILAR)

Question 86

T/F Aeseptic technique during surgical procedure is required if non-survival surgery is being performed.

Answer 86

False

Question 87

Room illumination should provide for nueroendocrine regulation of ________ and ________ cycles.

Answer 87

diurnal; circadian

Question 88

T/F Rats and guinea pigs requuire the same minimum cage height according to the *Guide*.

Answer 88

True

Question 89

Which word is used in the *Guide* to describe aspects of an animal care program that are considered imperative?

Answer 89

Must

Question 90

How often should qualified personnel observe an animal's health and well-being during weekends and holiday periods?

Answer 90

Atleast once a day

Question 91

What width does the *Guide* recommend for animal facility corridors?

Answer 91

6 - 8 Feet

Question 92

T/F The attending veterinarian is responsible for approving the animal use protocols.

Answer 92

False

Question 93

Physical contact and communication among members of the same species refers to the ________ environment.

Answer 93

Social

Question 94

____ filters should be used to remove air-borne particles from recycled air.

Answer 94

HEPA (High Efficancy Particulate Air)

Question 95

T/F the *Guide* states that other animals should not be present when an animal is euthanized.

Answer 95

True

Question 96

The physical environment of a secondary enclosure, such as a room or barn, is referred to as the ______________.

Answer 96

Macroenvironment

Question 97

T/F The *Guide* does not recommend temperature ranges for specific species.

Answer 97

False

Question 98

The illumination level in an animal room must be sufficent to allow for ____, ____, and ____.

Answer 98

Good housekeeping practices; Adequate inspection of the animals; Safe working conditions for personnel

Question 99

Exposure to sound louder than ____ decibels can lead to increased adrenal weight and reduced fertility in rodents.

Answer 99

85

Question 100

T/F Irradiated diets can be considered as an alternative to autoclavavle diets.

Answer 100

True