The Pituitary Gland (Hypothalamus and the Pituitary Gland) Flashcards

(33 cards)

1
Q

what two organs are the ‘principal organisers of the endocrine system’

A

hypothalamus

pituitary gland

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2
Q

what connects the hypothalamus and the pituitary gland

A

a stalk called the infundibulum

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3
Q

the anterior pituitary is a direct extension of what type of tissue

A

epithelial origin - it is considered a true endocrine gland

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4
Q

the posterior pituitary is an extension of what type of tissue

A

it is an extension of the neural tissue

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5
Q

what are trophic hormones

A

trophic hormones govern the release of another hormone

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6
Q

both the hypothalamus and the anterior pituitary gland release trophic and non trophic hormones, true or false

A

true

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7
Q

not all hormones released by the hypothalamus are neurohormones true or false

A

false- all hormone released by the hypothalamus are neurohormones

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8
Q

all hormones released by the posterior pituitary are _________

A

neurohormones

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9
Q

all hormones released by the anterior pituitary are _________

A

classic endocrine hormones

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10
Q

what are trophic neurohormones

A

neurohormones secreted into capillaries travelling to anterior pituitary which govern release of anterior pituitary hormones

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11
Q

what are non-trophic neurohormones

A

neurohormones produced in the hypothalamus and travel to posterior pituitary (via axons of hypothalamic neurons) where they are released into BLOOD

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12
Q

what are the 5 hypothalamic “releasing hormones”

A

Thyrotrophin Releasing Hormone (TRH)

Corticotropin Releasing Hormone (CRH)

Growth Hormone Releasing Hormone (GHRH)

Gonadotrophin Releasing Hormone (GnRH)

Prolactin Releasing Hormone (PRH)

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13
Q

what are the 2 hypothalmic “inhibiting hormones”

A

Growth Hormone Inhibiting Hormone (GHIH) aka somatostatin

Dopamine aka Prolactin Inhibiting Hormone (PIH)

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14
Q

what is the hypothalamo-hypophyseal portal system

A

a network of tiny vessels which transfer trophic hormones from the hypothalamus to anterior pituitary

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15
Q

how is the anterior pituitary connected to the hypothalamus

A

via capillary portal system

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16
Q

what is the anterior pituitary also known as

A

adenohypophysis

17
Q

what is the posterior pituitary also known as

A

neurohypophysis

18
Q

the posterior pituitary stores and releases 2 peptide neurohormones what are they

A

vasopressin (ADH)

oxytocin

19
Q

where are the neurohormones released by the posterior pituitary synthesised

A

in the magnocellular neurons

20
Q

what is the function of vasopressin

A

regulates water balance

21
Q

what triggers the release of vasopressin

A

increase in plasma osmolarity

decrease in plasma volume/blood pressure

22
Q

what are the 2 sites of action of vasopressin

A

kidney collecting ducts (increases water reabsorption)

vascular smooth muscle (increased blood pressure)

23
Q

what is the function of oxytocin

A

milk ejection and uterine contraction

24
Q

what triggers the release of oxytocin

A

labour

suckling

25
what are the 2 sites of action of oxytocin
milk duct smooth muscle | uterine smooth muscle
26
what are first degree disorders
those in which the defect is in the cells that secrete the hormone
27
what are second degree disorders
those in which there is too little or too much trophic hormone from pituitary
28
what are third degree disorders
relate to hypothalamic defects
29
6 hormones are released from the anterior pituitary gland (they are all peptides) what are they
1. thyroid stimulating hormone (TSH) 2. adrenocorticotrophic hormone (ACTH) 3. Follicle stimulating hormone (FSH) 4. luteinising hormone (LH) 5. growth hormone (GH) 6. prolactin
30
what is the only anterior pituitary hormone that isn't a trophic hormone
prolactin
31
what is dexamethasone
similar to cortisol, it acts to lower the amount of ACTH released by the pituitary which in turn lowers cortisol secretion from the adrenal gland
32
what can excess cortisol cause
tissue breakdown Na+ retention insulin antagonsim
33
what tests can be used to diagnose Cushings
24hour urine free cortisol Dexamethasone test measuring plasma ACTH at the same time radiology