The Roles of Gene in Psychological Disorders

Question 1

What are some types of twin and family studies? What is molecular genetics, what are the different types?

Answer 1

Lecture 15, slide 4-6

Question 2

What is heritability? What have twin studies revealed about the heritability of PDs?

Answer 2

Lecture 15, slide 7-10

Question 3

What is a diathesis-stress model? Why may some individuals be more vulnerable to stressors?

Answer 3

Lecture 15, slide 12

Question 4

Discuss the genetic liability of PDs observed in twin studies?

Answer 4

Lecture 15, slide 13-14

Question 5

What is the issue with twin studies?

Answer 5

Lecture 15, slide 15

Question 6

Briefly discuss the human genome project.

Answer 6

Lecture 15, slide 17-23

Question 7

What are candidate gene studies?

Answer 7

Lecture 15, slide 24

Question 8

Discuss the SERT polymorphism in relation to PDs?

Answer 8

Lecture 15, slide 25-27

Question 9

Do specific genes and environments interact to cause depression? Use the 5-HTTLPR as an example. What do meta-analysis reveal about this, and why may the conclusions of meta-analysis be different?

Answer 9

Lecture 15, slide 29-30

Question 10

What is GWAS?

Answer 10

Lecture 15, slide 31

Question 11

What are SNPs?

Answer 11

Lecture 15, slide 32-33

Question 12

Why must lots of data be pooled when studying the effects of SNPs?

Answer 12

Lecture 15, slide 35

Question 13

What is the missing heritability problem?

Answer 13

Lecture 15, slide 36-37

Question 14

Why does the classification models of PDs matter?

Answer 14

Lecture 15, slide 38

Question 15

What are common variants? How were these variants found?

Answer 15

Lecture 15, slide 39-40.5

Question 16

What is a polygenic risk score? What are some clinical applications of PRS? What can PRS tell us?

Answer 16

Lecture 15, slide 40.5-43