The Somatosensory System Flashcards

1
Q

The somatosensory system reports the body’s interactions with its immediate surroundings via “touch and feel” sensing of ______ against the skin, and via _____ sensations

A

contact pressure; thermal

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2
Q

Its peripheral receptors are “tuned” to _____ among different qualities of the various stimuli to which they are responsive, e.g. texture and shape, hot vs. cold, innocuous vs. noxious

A

discriminate

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3
Q

the structural organization that gives rise to “somatotopic mapping” ensures
that _____ of the stimulus as applied to the body can be accurately identified

A

location

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4
Q

somatosensory reporting relies upon two “design characteristics”: _____ and _____.

A

Discrimination and location of the stimulus

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5
Q

somatotopic mapping → gives rise to _____, but note that location of individual receptive
fields within each dermatome is also mapped

A

dermatomes

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6
Q

peripheral somatosensory neurons are located in the ______, and is classified as?

A

dorsal root ganglia; pseudo-unipolar

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7
Q

the ______fiber travels as part of a peripheral nerve to enter the spinal cord via a dorsal root

A

afferent sensory

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8
Q

whereas somatosensory signals from the skin project into the brain via _____, allowing precise perception of location on the body surface

A

labeled lines

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9
Q

What does not use the labeled line concept to provide sensory inputs to the brain?

A

Visceral receptors

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10
Q

_____ receptors are broadly distributed, but they give rise to relatively few centrally projecting fibers

A

visceral

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11
Q

non-nociceptive and nociceptive fibers arising from the viscera therefore have a relatively large receptive field, which means _____ discrimination of the precise location

A

poor

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12
Q

in addition, _____ afferent fibers tend to synapse on spinal relay neurons that also convey somatic (body surface) sensory input

A

visceral

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13
Q

visceral stimuli may therefore be perceived as originating from a _____ site → our brain may refer neural signaling arising from visceral receptors to a _____ location

A

somatic

This is why people who is having heart problems will show signs of shoulder and neck pain

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14
Q

Even for heart attack, the brain perceives the signal as signal from the _____ of the body, where as it’s from the heart. “Shoulder and neck pain”

A

surface

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15
Q

peripheral fibers conveying _____ somatosensory afferent

signals are classified alphabetically (“A” and “C”)

A

non-proprioceptive

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16
Q

What fiber type?
-large diameter, heavy myelin sheath (fastest conducting)
− these may also be referenced as _____.

A

A-alpha; “Type 1”

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17
Q

What fiber type?
-medium diameter, myelinated
− these may also be referenced as _____.

A

A-beta; “Type 2”

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18
Q

What fiber type?

-small diameter, myelinated

A

A-delta

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19
Q

What fiber type?

-unmyelinated (slowest conducting)

A

C fibers

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20
Q

fibers conveying PROPRIOCEPTIVE afferent signals from muscle are classified numerically [from type I (_____) to type IV (_____)]

A

largest; smallest

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21
Q

Large Aα and Aβ (or Type 1 and 2) somatosensory fibers convey _____ information from the skin

A

Mechanical

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22
Q

smaller Aδ and unmyelinated C somatosensory fibers convey _____ information and _____.

A

thermal; pain

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23
Q

Mechanoreceptors in the skin provide our sensation of _____ and _____.

A

touch; feel

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24
Q

glabrous skin of the hands and feet contain four types of mechanoreceptors:
Superficial? (2)
Deep? (2)

A

Superficial: Merkel’s disk and Meissner’s corpuscle

Deep: Ruffini corpuscle and Pacinian corpuscle

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25
Q
Superficial receptors (Merkel's disk and Meissner's corpuscle): Give rise to \_\_\_\_\_afferent fibers.
-Have no end organ
A

Aα (Type1)

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26
Q
Deep receptors  (Ruffini corpuscle and Pacinian corpuscle) 
•give rise to \_\_\_\_\_afferent fibers.
• are embedded within an end organ structure (sensory nerve ending).
A

Aβ (Type2)

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27
Q

the receptive field is the _____ to which an applied stimulus will
trigger signaling along a particular afferent sensory fiber

A

spatial domain

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28
Q

The size (surface area) of the Type 1 (Aa) fibers of the receptive field is determined by the distribution of the multiple receptors that collectively feed into one particular fiber, which are _____ exposed to the stimulus energy (force of applied pressure).

A

DIRECTLY

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29
Q

The size (surface area) of the Type 2 (Aβ) fibers of the receptive field is determined by the _____ within which the sensory nerve ending is embedded, through which the stimulus energy (applied pressure) is transmitted to the sensory nerve ending.

A

end-organ structure

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30
Q

The cutaneous mechanoreceptors are also classified as either _____ or _____ adapting to “report” different characteristics of the applied stimulus

A

slowly; rapidly

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31
Q

slowly adapting:
• _____ signaling (at a relatively steady frequency) throughout the duration that the stimulus is applied
• continued reporting → the stimulus is _____

A

maintains; sustained

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32
Q

rapidly adapting:
• maintains signaling just while the
stimulus intensity is _____
• reports “_____” and “_____”, and more generally, variations in the stimulus intensity

A

changing; “stimulus on” and “stimulus off”

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33
Q

Merkel’s disk and Meisner’s corpuscle are _____ mechanoreceptors.

A

superficial

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34
Q

Which type of mechanoreceptors consist of a individual mechanosensitive nerve terminals associated with a small
flattened non-neural epithelial cell (the “end organ”)?

A

Superficial mechanoreceptors: Merkel’s disk and Meisner’s corpuscle

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35
Q

Which type of mechanoreceptor’s receptive field for both types is relatively small, providing relatively fine spatial
resolution → good discrimination of location?

A

Superficial mechanoreceptors: Merkel’s disk and Meisner’s corpuscle

36
Q

Superficial mechanoreceptors: Merkel’s disk and Meisner’s corpuscle
• afferent fibers are classified as either ___ or _____.

A

Aα; Type 1

37
Q

Merkel’s disks are ______: responsive to continually applied pressure

A

slowly adapting (SA1)

38
Q
Meissner’s corpuscles are \_\_\_\_\_: responsive to repetitive, low
frequency stimuli (sensitivity is to light touch)
A

rapidly adapting (RA1)

39
Q

Pacinian and Ruffini corpuscles are _____ mechanoreceptors.

A

Deep

40
Q

Which type of mechanoreceptors has a large, specialized end organ that creates a relatively LARGE receptive field?

A

deep mechanoreceptors: Pacinian and Ruffini corpuscles

41
Q

deep mechanoreceptors: Pacinian and Ruffini corpuscles

• afferent fibers are classified as either _____ or _____.

A

Aβ; Type 2

42
Q

Ruffini’s corpuscles are ______: signaling sustained pressure

A

slowly adapting (SA2)

43
Q

Pacinian corpuscles are ______: signaling changes in pressure (e.g. vibrations)

A

rapidly adapting (RA2)

44
Q

slowly adapting mechanoreceptors report steady applied pressures, to enable discrimination of the _____ and _____ of objects pressing against the skin

A

shape; size

45
Q

the _____ of signaling reports the intensity of the stimulus (i.e. how forceful the pressure is being applied to the skin surface)

A

frequency

46
Q

_____ adapting mechanoreceptors report changing stimulus energy, e.g.
that caused by vibration or motion

A

rapidly

47
Q

somatotopic mapping and transmission of sensory information from each receptive field via labeled lines contributes to discernment of? (2)

A
  • points of contact with the object being grasped

* the size and shape of objects that we grasp

48
Q

the mixed population of receptor types allows discernment of (2)

A
  • surface texture

* movements of the object relative to the surface of the fingers and hand

49
Q

Hair follicle receptors:
• each follicle is innervated by _____ nerve ending
• deformation (bending) induces a _____ potential
• may be both slowly and rapidly adapting

A

a single; generator

50
Q

Cutaneous thermoreceptors individually respond to changes within a _____ range of surface (skin) temperature

A

limited

51
Q

T/F: individual thermoreceptors respond to either heat (↑ temperature) or cold
(↓ temperature), but not to both; more so to cold than to heat

A

TRUE

52
Q

Thermoreceptors are limited in their individual response ranges, based
upon skin temperature (Ts):
– heat receptors [warm to hot]: 95 to 110°F (___ fibers) – cold receptors [cool to cold]: 85 to 60°F (___ fibers)

A

C; Aδ

53
Q

thermoreceptors are most sensitive to changes in temperature; most adapt _____ to sustained temperature

A

rapidly

54
Q

___ threshold cold receptors detect rapid drops in temperature below 88°F; ___ threshold cold receptors/nociceptors detect rapid drops in temperature in the lower range (down to and below 32°F)

A

low; high

55
Q

Warm receptors report increases in temperature above 97°F, but are _____ rapidly adapting that cold receptors, are also much _____ sensitive to temperature change than cold receptors, providing _____ sensitivity to warming than to cooling

A

less

56
Q

separate cold and heat nociceptors generate the perception of _____ to either cold [Ts below 60°F] or heat [Ts above 110°F]

A

pain

57
Q

We are only aware of _____ in temperature, thermoreceptors are _____ adapting.

A

change; rapidly

58
Q

Thermoreceptors can also be fired off by ______.

A

botanics/chemicals (hot peppers)

59
Q

Pain is the perception of _____ (tissue damaging) stimuli

A

noxious

60
Q

nociceptors transduce painful stimuli arising from all three somatosensory
modalities:
• _____ → both sharp and sustained pressure
• _____ → hot (Ts > 110°F) and cold (Ts < 60° F)
• _____ → irritants, e.g. acid, inflammatory molecules

A

mechanical; thermal; chemical

61
Q

_____ nociceptors are responsive to a combination of the above modalities.

A

Polymodal

62
Q

_____generally consist of free nerve endings with little or no
specialized structures. There is little to no “modulation” (either focusing or spreading out) through an accessory structure to the receptor

A

Nociceptors

63
Q

What differentiates a nociceptor from a non-nociceptive somatosensory receptor is the receptor’s _____

A

stimulus threshold

64
Q

Nociceptors have a _____ stimulus threshold, compared to non- nociceptive receptors

A

higher

65
Q

a greater stimulus intensity is therefore required to initiate signaling from _____

A

nociceptors

66
Q

nociceptive signaling is conveyed from the periphery into the CNS via ___ and ___ fibers

A

Aδ; C

67
Q

Nociceptive signaling: -Aδ fibers arise from mechanical and thermal nociceptors; convey _____sensation of pain

A

sharp (short lasting)

68
Q

Nociceptive signaling: -C fibers arise from polymodal receptors; convey ___ or ___ pain

A

dull; diffuse

69
Q

______ → is reflected as the strength of the nervous signaling that the receptor generates in response to a given strength of stimulus intensity.

A

receptor sensitivity

70
Q

Mechanoreceptor normally respond to that amount of force by signaling at 10 Hz:
• if the response is now 14 Hz → _____ sensitivity
• if the response is now 7 Hz → _____ sensitivity

A

increased; decreased

71
Q

Receptor sensitivity is determined by the receptor’s stimulus threshold:
• lower stimulus threshold→______ sensitivity
•higher stimulus threshold→______ sensitivity

A

higher (more responsive) ; lower (less responsive)

72
Q

_____ → sensitization (an increase in the receptor sensitivity)
• in effect, the stimulus threshold for these receptors is reduced, which leads to:
− a perception that a given stimulus is more painful than normal
− what is normally a non-noxious stimulus may now be perceived as painful

A

hyperalgesia

73
Q

_____ → desensitization (a reduction in the receptor sensitivity)
in effect, the stimulus threshold for these receptors is elevated, which leads to:
− a perception that a given stimulus is less painful than normal
− what is normally a noxious stimulus may now be perceived as non-painful

A

analgesia

74
Q

_____ hyperalgesia may arise from sensitization of peripheral nociceptors, e.g. by various chemical substances

A

primary

75
Q

Secondary hyperalgesia may arise from a change in the strength of _____ of peripheral afferent signals arising from the nociceptors to the second order relay neurons

A

synaptic transmission

76
Q

released neuropeptides such as substance P and CGRP may also stimulate inflammation by sensitizing and/or activating surrounding nociceptors.
→ ______

A

neurogenic inflammation

77
Q

During hyperalgesia; uninjured tissue’s nociceptor stimulus threshold are relatively _____

A

High

78
Q

During hyperalgesia; injured tissue’s nociceptor stimulus threshold are _____

A

reduced

79
Q

The SURROUNDING mechanical hyperalgesia may be due to sensitization of C-fiber nociceptors, as well as from _____ sensitization of C-fiber neurotransmission within the spinal cord.

A

secondary (2nd order neurons) Surrounding= Not localized/within the area, into spinal cord

80
Q

secondary hyperalgesia may arise from sensitization of the dorsal horn synaptic relay for _____nociceptive signaling

A

ascending

81
Q

Analgesia is _____ sensitivity to a painful stimulus

A

reduced

82
Q

_____: pain due to a stimulus that does not normally provoke pain
→ usually due to sensitization within the CNS, causing non-nociceptive inputs (e.g. light touch) to activate pain pathways via spinal interneurons

A

allodynia

83
Q

______: pain initiated or caused by a primary lesion or dysfunction within the central nervous system
→ disease, trauma, or space-occupying lesions that alter normal function of tracts, nuclei and cell bodies of the nervous system in a way that stimulate nociceptive pain pathways

A

central pain

84
Q

_____: pain in the distribution of a nerve or nerves
→ typically described as lancinating (tearing, darting, sharply cutting) or paroxysmal (sudden recurrence, spasms), occurring spontaneously or triggered in response to minimal stimuli (allodynia)

A

neuralgia

85
Q

_____: pain initiated or caused by a primary lesion, dysfunction, or transitory perturbation in the peripheral or central nervous system
→ normally resulting from sensitization of nociceptors, dorsal root ganglia, and dorsal horn neurons and interneurons, presenting clinically as spontaneous pain, hyperalgesia, and allodynia

A

neurogenic pain