things to remember Flashcards

Question

Eravacycline:

Answer 1

``` Eravacycline: Same + Anaerobes • Streptococcus • VRE • MSSA • MRSA • GNR • Anaerobes ```

Answer 2

inhibit both DNA gyrase and Topoisomerase (prevents DNA from Replicating) Bactericidal black box warning and lots of bad ADR's

Answer 3

Ciprofloxacin -bacteriocidal *DOSE ADJUST RENAL* • VSE • GNR*bold • Psuedomonas*bold

Answer 4

Levofloxcain-bacteriocidal → RESPIRATORY FLUROQUINOLONE *DOSE ADJUST RENAL* * Streptococcus * VSE * GNR* * HNM* * Psuedomonas* * Atypicals

Answer 5

``` Moxifloxacin → Respiriatory Covers: • Streptococcous • GNR* • HNM* • Pseudomonas* • Atypical • Anaerobes ```

Answer 6

``` Oxifloxacin – bacteriocidal Covers: • Streptococcous • MSSA • GNR* • HNM* • Pseudomonas* ```

Answer 7

``` Delafloxacin → Respiratory Fluroquinolone Dose adjust renal Covers • Streptococcus • MSSA • MRSA • GNR* • HNM* • Pseudomonas* • Atypical ```

Answer 8

inhibits protein synthesis prevents tRNA binding to 50s ribosomal subunit bacteriostatic streptococcus H+ Atypicals H. pylori think Jersey shore StHAHp clarith and erytho inhibit drug metabolism by CYP enzymes dose adjustment liver

Answer 9

inhibit protein synthesis (prevents tRNA binding to 50s ribosomal subunit) bacteriostatic streptococcus MSSA GP+ multiple day dosing to avoid side effects -associated with c. diff infections Dose adjustment LIVER

Answer 10

GP+ anaerobes esp. C. diff ADRs peripheral neuropathy GI intolerance metallic tase

Answer 11

inhibits formation of nucleic acids by inhibiting folic acid synthesis SMX inhibits pteroate ***TMP inhibits folate reductase → dosing is based on this component ``` streptococcus MSSA MRSA GNR HNM ```

Answer 12

irreversibly bind with 30s subunit causing mRNA to be misread Bacteriocidal ``` Synergistic coverage for GPC endocarditis streptococcus VSE VRE MSSA MRSA ``` by themselves GNR Psuedomonas MONITOR PEAKS AND TROUGHS --HAVE POST ANTIBIOTIC EFFECT (2-4hrs)

Answer 13

high bolus at beginning

Answer 14

give smaller doses more frequently

Answer 15

SUSCEPTIBLE GNR → used to treat UTI's (CYSTITIS) *** CrCl must be greater than 50 -- dependent on renal function to be therapeutic in bladder

Answer 16

Metabolized within the bacterial cell to reactive intermediates that destroy DNA and ribosomal proteins Bacterialcidal

Answer 17

binds to 5Os subunit and doesn't let 30s attach → no protein synthesis occurring bacteriostatic ``` Streptococcus VSE VRE MSSA MRSA GP+ anaerobes ``` ADR's thrombocyopenia and serotonin syndrome Dose adjust liver

Answer 18

binds with calcium and creates holes in phospholipid membrane bacterialcidal ``` Streptococcus VSE VRE MSSA MRSA GP+ anaerobes ``` particularly used for MRSA and VRE infections

Answer 19

``` VSE VRE MSSA MRSA GP+ anaerobes ``` particularly used for VRE infections Liver bactericidal

Answer 20

bactericidal inhibits RNA polymerase and prevents RNA production can develop resistance when used for long time Induces CYP enzymes and increases clearance of many drugs MSSA MRSA +HN LIVER

Answer 21

Inhibits enzyme Mur A→ inhibits cell wall synthesis bacterialcidal ``` VSE VRE MSSA MRSA GNR (accept acinobacter) Pseudomonas ``` only therapeutic in bladder → used for mild UTI's

Answer 22

binds to RNA polymerase and doesn't let transcription occur covers specifically C-diff (refractory c-diff) very $$$

things to remember Flashcards

(46 cards)