Thrombin Inhibitor Flashcards Preview

Pharmacology - Blood > Thrombin Inhibitor > Flashcards

Flashcards in Thrombin Inhibitor Deck (5)
Loading flashcards...
1
Q

What are examples of thrombin inhibitors?

A

Dabigatran

2
Q

What are indications for the use of thrombin inhibitors?

A
  • Prophylaxis of venous thromboembolism following surgery
  • Prophylaxis and treatment of DVT and PE
  • Prophylaxis of stroke and systemic embolism in non-valvular AF
3
Q

What are contraindications of thrombin inhibitors?

A
  • Active bleeding
  • Oesophageal varices
  • Malignant neoplasms
  • Recent brain/spine surgery
  • Recent intracranial haemorrhage
  • Severe liver disease
  • Pregnancy and breastfeeding
4
Q

What is the mechanism of action of dabigatran?

A

Dabigatran is a competitive direct inhibitor of thrombin, thereby inhibiting the coagulation cascade as thrombin is the enzyme required to convert fibrinogen to fibrin

5
Q

What are adverse reactions of thrombin inhibitors?

A
  • Abdominal Pain
  • Diarrhoea
  • Dyspepsia
  • Nausea
  • Haemorrhage