thrombocytopenia

Question 1

what is it?

Answer 1

Acquired – reduced production, increased destruction

Question 2

What causes peripheral platelet destruction?

Answer 2

• Coagulopathy – Disseminated intravascular coagulation
• Autoimmune – Immune thrombocytopenic purpura (ITP)
• Hypersplenism

Question 3

What causes functional platelet defects?

Answer 3

• Drugs – e.g. aspirin, NSAIDs

* Renal failure

Question 4

vWF deficiency

Answer 4

• Hereditary autosomal dominant, common

* Variable severity – generally mild