Thrombolytic Drugs Flashcards Preview

Pharmacology - Test #4 > Thrombolytic Drugs > Flashcards

Flashcards in Thrombolytic Drugs Deck (13):
1

How do tissue plasminogen activators work?

Cleave Arg-Val bond to activate Plasmin

2

Plasmin is turned off by

alpha2-antiplasmin

3

tPA is inhibited by...

PAI-1 and PAI-2

4

Difference in how streptokinase and recombinant tPA work

Strep - Forms activator complex with plasminogen
tPA -- Catalyzes conversion of plasminogen to plasmin

5

Indications for thrombolytic therapy

MI asap
Ischemic thrombotic stroke (w/in 3 hrs, exclude hemorr.)
PE

6

Three major forms to tPA

Alteplase
Reteplase
Tenecteplase

7

Important differences in Reteplase and Tenecteplase from Alteplase

Tenec -- Recombinant, longer 1/2 life, more fibrin specific
Rete -- More potent, but loss of binding domain -> less specific

8

Difference in where tPAs work?

Alt and Tenec -- cleave plasminogen that is already bound to fibrin
Rete -- hits plasmin and plasminogen everywhere

9

Important details about tPAs

IV admin
1/ life of 5/10 mintues
Can cause bleeding probs

10

How do anti-fibrinolytic agents work

Act as a lysine analog to bind the receptor on plasminogen and plasmin to blockade plasmin binding to fibrin

11

Clinical used of anti-fibrinolytic agents

Treat bleeding associated with thrombolytic therapy
Adjunct therapy in hemophilia
Re-bleeding from intracranial aneurysms

12

Major risks of anti-fibrinolytic agents

Intravascular thrombosis as result of fibrinolysis inhibition
Thrombi formed during therapy are not easily lysed

13

Name the two main anti-fibrinolytic agents

Aminocaproic Acid
Tranexamic acid