Thrombophilia Flashcards
(9 cards)
What is thrombophilia?
Inherited or acquired coagulopathy that predisposes people to thrombosis
What are the symptoms of thrombophilia?
Normally find out that you have thrombophilia after having a blood clot
- Stroke at young age
- Repeated miscarriages
- Pregnancy problems
- MI
When does screening for thrombophilia occur?
- After having DVT or PE
- After pregnancy
- Have to be off anticoagulants for 3 weeks +
What are the most common inherited thrombophilias?
Factor V Leiden
Protein C deficiency
Protein S deficiency
Antithrombin deficiency
What is the most common autoimmune thrombophilia?
Antiphospholipid/Hughes’ syndrome
What happens in Factor V Leiden thrombophilia?
Gene affects factor V which makes it not able to be broken down by protein C
- This prolongs the clotting process
Is the risk of blood clots the same for all patients with Protein C or S deficiency?
Risk of blood clot forming varies between families as each family has a different alteration in the PC or PS gene.
What happens in antithrombin deficiency?
Antithrombin cannot effectively inhibit thrombin
What is the usual treatment for thrombophilia?
- Low-dose aspirin
- Anticoagulants
