Thromboprophylaxis Flashcards Preview

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Flashcards in Thromboprophylaxis Deck (7)
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1
Q

Mechanical prophylaxis

A
  • Early ambulation after surgery is cheap and is effective
  • Compression stockings (contra -indicated in peripheral arterial disease)
  • Intermittent pneumatic compression devices
  • Foot impulse devices
2
Q

Low molecular weight heparin mechanism

A

Binds antithrombin resulting in inhibition of factor Xa

3
Q

LMWH use

A

In patients with normal renal function, low doses typically given in those with moderate to high risk of thromboembolic events. It is given as once daily subcutaneous injection

4
Q

Unfractionated heparin mechanism

A

Binds antithrombin III with affects thrombin and factor Xa

5
Q

Unfractionated heparin use

A

Effective anticoagulation, administered intravenously it has a rapid onset and its therapeutic effects decline quickly on stopping and infusion. Its activity is measured using the APTT. If need be it can be reversed using protamine sulphate

6
Q

Dabigatran mechanism

A

Orally administered direct thrombin inhibitor

7
Q

Dabigatran use

A

Used prophylaxis in hip and knee surgery. It does not require therapeutic monitoring. It has no known antidote and should not be used in any patient in whom there is a risk of active bleeding or imminent likelihood of surgery