thrombosis & embolism Flashcards
describe process of thrombosis
process of thrombus formation
endothelial injury
stasis/turbulent blood flow
hypercoagulability of the blood
(virchow’s triad)
thrombin
unique molecule that functions as both procoagulant and anticoagulant
define thrombus
solidification of blood constituents formed within vascular system during life
explain significance of Virchow’s triad
explain relationship between atheroma and thrombosis
list factors causing thrombosis
injury to vein , eg surgery, broken bone, trauma
lack of movement ie after surgery
inherited blood clotting disorders
central venous catheter
list factors causing embolism
pulmonary : blood clots traveling to lungs from deep veins
cardiac : atrial fibrillation
different types of embolism
pulmonary cardiac thromboembolism fat embolism air embolism septic embolism
aetiology of thrombosis
multifactorial
virchow’s triad !!!!!!!
normal blood flow
LAMINAR
abnormal blood flow
STASIS : stagnation of flow
TURBULENCE : forceful, unpredictable
virchow’s triad
changes in blood vessel wall
changes in blood constituents
changes in pattern of blood flow
define embolism
movement of abnormal material in the bloodstream and its impaction in a vessel, blocking its lumen
define embolus
detached intravascular solid, liquid, gaseous mass
most emboli are dislodged thrombi (thromboembolism)
types of embolus
thrombus fat gas tumour trophoblast septic material amniotic fluid bone marrow foreign bodies
