Thrombotic Disorders Flashcards
(23 cards)
what are the elements of haemostasis
primary haemostasis
blood coagulation
fibrinolysis
explain what happens in primary haemostasis
primary plug vessel wall constriction vasoconstriction platelet activation tissue factor platelet adhesion platelet aggregaton
explain what happens in blood coagulation
insoluble fibrin formation
fibrin cross linking
explain what happens in fibrinolysis
urokinase
tissue plasminogen activator
breakdown of fibrin clot
plasmin breaking down fibrin
what is a thrombus
clot arising in the wrong place
what is a thromboembolsim
movement of a clot along a vessel
what are the 3 parts of virchows triad
stasis
hypercoagulbility
vessel damage
what are factors causing stasis
bed rest
travelling
what are factors of vessel wall damage
atheroscerlosis
what are factors causing hypercoagulbilty
preganncy-vessel wall damage
trauma
what types of thrombus are there
arterial
venous
microvascular
what is an arterial thrombus
platelets and fibrin
tissue becomes ischameic
what are types of arterial thrombus
coronary thrombosis
CV thromboemobilsm- stroke
peripheral embolism-limbs
how do you manage an arterial thrombus
primary-lifestye
acite-thrombolysis
what is a venous thrombus
red
fibrin and RBC
what is a venous thrombus
red clot
fribin and RBC
what are examples of venous thrombus
deep vein thrombosis
pulmonary embolism
visceral venous thrombosis
superficial vein
what are the investigation for a venous thrombosis
wells score geneva score doppler d dimer CT
what is the management for a venous thrombosis
prevent clot extensoon prevent embolism prevent reoccrance LMWH warfarin thrombolysis
what is microvascular thrombus
platelets and or fibrin resulting in diffuse ischaemia
what causes microvasular thrombus
malignancy
septiceamia
prgenancy
what are examples of inheritable thrombophilia
factor V leiden-antithrombin
Prothrombin
explain factor v leiden
block factor 8
block facto 5
