Thrp (HIV) Flashcards by C Hill

Lamivudine (3TC)

Epivir - NRTI
with our without food

Well tolerated

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Emtricitabine (FTC)

Emtriva - NRTI
with or without food

AE: Hyper-pigmentation of palms and soles

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Tenofovir (TDF)

Viread - NRTI
With or without food

AE: GI, Renal insufficiency, potential for osteopenia

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Zidovudine (ZDV)

Retrovir - NRTI

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Abacavir (ABC)

Ziagen - NRTI
with or without food

Dec Efficacy with VL >100,000 copies/mL DONT USE
AE: Hypersensitivity rxn: DO **HLA-B5701 Testing
MI risk: A weak association, NOT an Absolute CI

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Didanosine (ddl)

Videx - NRTI

hight risk of AE: Lactic acidosis with hepatic steatosis

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Stavudine (d4T)

Zerit - NRTI

Greatest AE: Lactic acidosis with hepatic steatosis

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Ritonavir (RTV)

Norvir - “Booster” (old - Protease Inhibitor)

TAKE AT SAME TIME AS P.I.
AE: GI intolerance, Hepatitis, Peresthesias

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Cobicistat

In combo’s - “Booster”

TAKE AT SAME TIME AS P.I.
AE: Inc SrCr and get changes is eGFR but not aGFR
GI < RTV (well tolerated)

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Tenofovir + Emtricitabine

Truvada

Preferred NRTI combo *THE NRTI Back-Bone; always

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Abacavir + Lamivudine

Epizicom

Alternative to preferred NRTI combo

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Zidovudine + Lamivudine

Combivir

Alternative to preferred NRTI combo *Preferred in Prego

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Efavirenz (EFV)

Sustiva - NNRTI *Prefereed in Naive Pts
On and EMPTY stomach (food inc SE)

AE: CNS (vivid dreams, subside due to dec blood [ ] as a result of the auto-induction effect from drug) Skin rash (tx anti-H, Teratogen (NEVER IN PREGO OR POTENTIAL PREGO), Inc LFT/LDL/TC/TG/HDL, False+ for cannabinoid and BDZ

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Nevirapine (NVP)

Viramune - NNRTI

Preferred in Prego

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Delavirdine (DLV)

Rescriptor - NNRTI

Inferior NNRTI and NOT USED

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Etravirine (ETR)

Intelence - NNRTI

Only in Tx-experienced pts (Consider if Resistance)

Rilpivirine (TMC278)

Edurant - NNRTI *alt. to preffered in Naive Pts
WITH food

AE: Skin rashe (watch and Tx Anti-H) Depressive Ds.

AVOID in pts with VL>100K or CD4<200

Efavirenz + Tenofovir + Emtricitabine

Atripla * preferred Regim

Rilpivirine + Tenofovir + Emtricitabine

Complera

Atazanavir (ATV)

Reyataz - Protease Inhibitor (Always boosted with RTV) Preferred Regimen [Unboosted = alternative] in Tx-Experirenced pts
Take WITH Food
*Only PI that is NOT BID dosing
Preferred in Prego

AE: Best tolerated PI, least hyperlipidemia
N/V, Diarrhea
Gall stone Dz (inc. fluid intake), fat maldistribution (hump) Nephrolithiasis, hyperbilirubenemia

Darunavir (DRV)

Prezista - Protease Inhibitor (Always boosted with RTV) Preferred Regimen in Tx-Experirenced pts
Take WITH Food
BID

AE: Well tolerated PI, least hyperlipidemia
N/V, Diarrhea
Rash (sulfer moiety, monitor), hepatotoxicity, Fat maldistribution

Fosamprenavir (FPV)

Lexiva - Protease Inhibitor (Always boosted with RTV)

AE: hyperlipidemia N/V, Diarrhea

Lopinavir/Ritonavir

Kaletra - Protease Inhibitor (Always boosted with RTV)
Preferred in Prego

AE: hyperlipidemia N/V, Diarrhea

Sauinavir (SQV)

Invirase - Protease Inhibitor (Always boosted with RTV)

AE: hyperlipidemia N/V, Diarrhea

Tipranavir (TPV)

Aptivus - Protease Inhibitor (Always boosted with RTV) AE: hyperlipidemia N/V, Diarrhea

Dolutegravir (DTG)

Tivicay - Integrase Inhibitor (newest agent but probably be new preferred agent) With OR without food AE: Hypersensitivity, insomnia, HA elevated Cr (well tolerated)

Elvitegravir (EVG)

- Integrase Inhibitor ONLY available as a compnent of "single Tablet Regimen" Stribild (combo = with food) AE: N/D elevated Cr (Well tolerated

Stribild

an "STR" - Tenofovir/Emtricitabine/Elvitegravir/Cobicistat With food Alternative regimen in Tx-naive pts with CrCl>70mL/min BUT artificial Cr boost??

Raltegravir (RAL)

Isentress - Integrase Inhibitor **Preferreed agent in Tx-Naive pts (IN COMBO with emtricitabine) * Can be used in Tx-Experienced pts IF naive to Integrase Inhibitors With OR without food AE: N/D, significant HA requiring d/c

Enfuvirtide (t20)

Fuzeon - Fusion Entry Inhibitor (injection) | Indicated in Tx-Experienced pts only (not used)

Maraviroc (MVC)

Selzentry - CCR5 antagonist entry inhibitor Can use in Tx- Naive pts IF* (mosty Tx-experienced) Use requires "Trofile" co-Receptor assay: Tests to see if virus strain uses CCR5 co-recepter to enter the CD4+ cell - if so can use Rx If test shows virus is an X4 virus then has mutated to use CXCR4 co-receptor (more virulent) AE: Cough,