Thursday 1 - Trachte - Arachadonic acid metabolites Flashcards Preview

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Flashcards in Thursday 1 - Trachte - Arachadonic acid metabolites Deck (22)
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1
Q

NSAID’s inhibit the synthesis of what?

A

Prostaglandins from arachadonic acid.

2
Q

Which enzyme is most likely to release arachidonic acid from the membrane

A

Phospholipase A2

3
Q

4 things that prostaglandins are made into from class

A

PGE2
PGF2
Prostacyclin
Thromboxane

4
Q

This arachadonic product causes inflamation, increased capillary permeability.

A

PGE2

5
Q

This arachadonic product signals for the start of your period, along with menstrual pain.

A

PGF2

6
Q

This arachadonic product inhibits clotting and prevents M.I.s

A

Prostacyclin

7
Q

This arachadonic product causes blood clotting and potentially M.I.s

A

Thromboxane A2

8
Q

COX2 inhibitors primarily block this arachidonic acid metabolite.

A

Prostacyclin

9
Q

This will be at the end of the drug name if it is a COX2 inhibitor

A

“coxib”

ie celecoxib (celebrex)

10
Q

3 Cyclooxygenase inhibitors (NSAIDS)

A

Acetylsalicylic acid (asprin)
Celecoxib (celebrex)
Ibuprofen

11
Q

4 Corticosteroids

A

Dexamethasone
Hydrocortisone
Methylprednisolone
Prednisone

12
Q

Non antiinflam. COX inhibitors

A

Acetaminophen

13
Q

5 things corticosteroids inhibit

A

Arachidonic acid, IL-1, IL-6, TNF, leukotrienes

they are transcriptional regulators

14
Q

Side effects of corticosteroids

A
osteoporosis
immune suppression
peptic ulcers
myopathy
cataracts
fluid accumulation, hyperglycemia
15
Q

What general class of drug inhibits both prostaglandins and leukotrienes?

A

Corticosteroids

16
Q

Leukotrienes

A

participate in allergic responses such as asthma

17
Q

What selectively prevents leukotriene synthesis?

A

Zileuton

18
Q

Relieves arthritis and reduces risk of MI?

A

acetylsalicylic acid

19
Q

Effective arthritis treatment with least risk of gastric ulceration?

A

celecoxib (celebrex)

20
Q

What F.A. may cause a bleeding tendency and resistance to M.I.

A

Fish oil (eicosapentaenoic acid)

21
Q

How do you treat the SYMPTOMS of rheumatoid arthritis?

A

inhibit prostaglandin synth. this only treats symptoms

22
Q

Major effects of corticosteroids

A

reduction in WBC

reduction in arachidonic acid liberation