NSAID’s inhibit the synthesis of what?
Prostaglandins from arachadonic acid.
Which enzyme is most likely to release arachidonic acid from the membrane
Phospholipase A2
4 things that prostaglandins are made into from class
PGE2
PGF2
Prostacyclin
Thromboxane
This arachadonic product causes inflamation, increased capillary permeability.
PGE2
This arachadonic product signals for the start of your period, along with menstrual pain.
PGF2
This arachadonic product inhibits clotting and prevents M.I.s
Prostacyclin
This arachadonic product causes blood clotting and potentially M.I.s
Thromboxane A2
COX2 inhibitors primarily block this arachidonic acid metabolite.
Prostacyclin
This will be at the end of the drug name if it is a COX2 inhibitor
“coxib”
ie celecoxib (celebrex)
3 Cyclooxygenase inhibitors (NSAIDS)
Acetylsalicylic acid (asprin)
Celecoxib (celebrex)
Ibuprofen
4 Corticosteroids
Dexamethasone
Hydrocortisone
Methylprednisolone
Prednisone
Non antiinflam. COX inhibitors
Acetaminophen
5 things corticosteroids inhibit
Arachidonic acid, IL-1, IL-6, TNF, leukotrienes
they are transcriptional regulators
Side effects of corticosteroids
osteoporosis immune suppression peptic ulcers myopathy cataracts fluid accumulation, hyperglycemia
What general class of drug inhibits both prostaglandins and leukotrienes?
Corticosteroids
Leukotrienes
participate in allergic responses such as asthma
What selectively prevents leukotriene synthesis?
Zileuton
Relieves arthritis and reduces risk of MI?
acetylsalicylic acid
Effective arthritis treatment with least risk of gastric ulceration?
celecoxib (celebrex)
What F.A. may cause a bleeding tendency and resistance to M.I.
Fish oil (eicosapentaenoic acid)
How do you treat the SYMPTOMS of rheumatoid arthritis?
inhibit prostaglandin synth. this only treats symptoms
Major effects of corticosteroids
reduction in WBC
reduction in arachidonic acid liberation