Thyroid

Question 1

Autoimmune disease associated with Hashimoto’s

Answer 1

Adrenal insufficiency (Schimdt)
DM
JIA
SLE
APS II

Question 2

Ddx hyperthyroidism

Answer 2

Graves
Thyroid autonomy- adenoma, activating mutation of G protein (McCune-Albright)
Thyroid inflammation- subacute thyroiditis, Hashimoto
Exogenous

Question 3

Graves’ disease antibodies

Class
Action

Answer 3

Bind TSH R
Stimulating thyroid hormone production

IgG

Question 4

Chronic lymphocytic thyroiditis presents as…

What proportion resolve

Antibody associated

Answer 4

Euthyroid goitre

50%

Anti-TPO

Question 5

Causes of congenital hypothyroidism

Answer 5

Primary: agenesis, dysgenesis, ectopic, dyshormonogenesis

Secondary: hypopituitism, hypothalamic abnormalities

Other: maternal iodine deficiency, goitrogen ingestion

Question 6

Proportion of solitary thyroid nodules malignant adolescence

Answer 6

20-40%

Question 7

Thioamide derivatives action

Thyroid storm treatment

Answer 7

Block synthesis of T3 & T4 not the release

Slow onset

Propanolol
Iodide
Steroids

Question 8

Investigations solitary thyroid nodule

Answer 8

USS

Scintiscan :

cold nodule - carcinoma or adenoma

Patchy uptake- hashimotos

Poorly functioning lobe - subacute thyroiditis