Thyroid Disease

Question 1

Commonest cause of congenital hypothyroidism? List other causes.

Answer 1

Thyroid dysgenesis/agenesis (75%)

Others:
Dyshormonogenesis (20%)
Transient neonatal hypothyroidism (10-20%)
Isoimmune (5%)

Question 2

Clinical presentation of neonatal hypothyroidism?

Answer 2

Lethargy
Poor feeding
Hypotonia
Jaundice
Poor temp control

Question 3

What is the risk of neonatal hyperthyroidism assoc. with Graves’ disease?

Answer 3

2%

Question 4

T/F Carbimazole and PRU suppress maternal thyroid stimulating antibodies

Answer 4

True

Question 5

T/F screening for congenital hypothyroidism is based on detecting low neonatal levels of T3 and T4.

Answer 5

False. TSH levels are assessed from a heel prick sample

Question 6

What is the Guthrie test?

Answer 6

Test for phenylketonuria.
Test for TSH assay done at same time.
Test is done after 48hrs of breastfeeding/an adequate milk diet