Thyroid Disease

Question 1

Hashimoto thyroiditis

Answer 1

Hyper > hypothyroid
Moderately enlarged thyroid
\+Anti-thyroid peroxidase
\+Antithyroglobulin antibodies
Increased risk of NHL

Question 2

Subacute thyroiditis (De Quervain)

Answer 2

Hyper > hypothyroid
Tender thyroid
Self-limited, often follows flu-like illness
Assoc. w/ jaw pain, increased ESR

Question 3

Riedel thyroiditis

Answer 3

Hypothyroid
Hard, painless goiter
Fibrosis of thyroid and adjacent structures

Question 4

Goiter (other causes)

Answer 4

Iodine deficiency
Cyanide ingestion
Thyroid hormone insensitivity
Drug-induced

Question 5

Graves Disease

Answer 5

Hyperthyroid

Thyroid-stimulating immunoglobulin binds to TSH receptor

Question 6

Toxic multinodular goiter

Answer 6

Hyperthyroid

Mutated TSH receptor > follicles releasing thyroid hormone independently