Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

305 Patho > Thyroiditis > Flashcards

Thyroiditis Flashcards

(50 cards)

Start Studying
1
Q

Thyroiditis, or inflammation of the thyroid gland,
encompasses a diverse group of disorders
characterized by some form of thyroid inflammation.

A

• (1) Hashimoto thyroiditis
• (2) Granulomatous (de Quervain) thyroiditis
• (3) Subacute lymphocytic thyroiditis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

HASHIMOTO THYROIDITIS (struma lymphomatosa) is a …. Disease

A

autoimmune

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Consequence of HASHIMOTO

A

destruction of the thyroid gland and gradual and
progressive thyroid failure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

The most common cause of hypothyroidism in areas of the world where ….. levels are sufficient

A

iodine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

HASHIMOTO THYROIDITIS

Ages

A

between 45 and 65 years of age

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

HASHIMOTO THYROIDITIS
Gender

A

More common in women than in men( a female predominance of
10:1 to 20: 1.)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

HASHIMOTO THYROIDITIS causes …in the pediatric population

A

nonendemic goiter

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

HASHIMOTO THYROIDITIS is cused by

A

Autoantibodies to thyroglobulin and thyroid
peroxidase(+)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What may cause Autoantibodies to thyroglobulin and thyroid peroxidase(+) in HASHIMOTO THYROIDITIS

A

. Abnormalities of regulatory T cells (Tregs) -
cytotoxic T lymphocyte-associated antigen-4 (CTLA4)
and protein tyrosine phosphatase-22 (PTPN22)
• Exposure to normally sequestered thyroid
antigens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

HASHIMOTO THYROIDITIS gross

A

➢ Diffuse enlargement ➢ Intact capsule ➢

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Cut surface if hoshimoto thyroiditis

A

pale, yellow-tan, firm, and somewhat nodular

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

HASHIMOTO THYROIDITIS LM

A

➢ A mononuclear inflammatory
infiltrate (small lymphocytes, plasma cells)
➢ Well-developed germinal centers
➢ Increase in interstitial connective tissue.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

fibrosis does not extend
beyond the capsule of the
gland in … but it does in…

A

HASHIMOTO THYROIDITIS
Reidel thyroiditis,

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

3 types of follicles in hashimoto thyroiditis

A

1.atrophied with no colloid
3.thyroid lined with hurthle cells
3.lymphoid follicles with germinal center formation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

HASHIMOTO THYROIDITIs mainly affects

A

Middle-aged women

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Clinical HASHIMOTO THYROIDITIS

A

Painless thyroid enlargement (symmetrical and widespread)

• Hypothyroidism ( gradually): T4 and T3 levels ↓, TSH↑

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

In some patients, thyroid hormones are released suddenly with…… and … may develop

A

disruption of thyroid follicles
transient thyrotoxicosis (“hashitoxicosis”)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

In transient thyrotoxicosis (“hashitoxicosis”)
Free T4 and T3 levels … TSH… and radioactive iodine uptake …

A

↑,

↓,

↓,

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Hashimoto thyroiditis increases the risk for

A

extranodal marginal zone B-cell lymphomas
within the thyroid gland

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

SUBACUTE LYMPHOCYTIC (PAINLESS) THYROIDITIS
Is most commonin

A

middle-aged adults and women

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

SUBACUTE LYMPHOCYTIC (PAINLESS) THYROIDITIS
Manifests as

Study These Flashcards
A

Mild hyperthyroidism and goiter enlargement of the gland

22
Q

Painless thyroiditis and postpartum thyroiditis are variants of

Study These Flashcards
A

autoimmune thyroiditis:

23
Q

autoimmune thyroiditis is caused by

Study These Flashcards
A

Antithyroid peroxidase antibodies Family history of other autoimmune diseases

24
Q

1/3 of cases of SUBACUTE LYMPHOCYTIC (PAINLESS) THYROIDITIS

Study These Flashcards
A

Hypothyroidism, histology like Hashimoto

25
SUBACUTE LYMPHOCYTIC (PAINLESS) THYROIDITIS Clinical
Slightly symmetrical enlargement of the thyroid gland, usually normal size Painless goiter, transient overt hyperthyroidism, or both • Transition from hyperthyroidism to hypothyroidism
26
SUBACUTE LYMPHOCYTIC (PAINLESS) THYROIDITIS LM
Lymphocytic infiltration with large germinal centers within the thyroid parenchyma and patchy disruption and collapse of thyroid follicles
27
GRANULOMATOUS THYROIDITIS (De Quervain thyroiditis) Age
The ages of 40 and 50
28
GRANULOMATOUS THYROIDITIS (De Quervain thyroiditis) Gender
Affects women considerably more often than men (4:1)
29
GRANULOMATOUS THYROIDITIS (De Quervain thyroiditis) Trigger
Viral infection Upper respiratory infection
30
Seasonal incidence of GRANULOMATOUS THYROIDITIS (De Quervain thyroiditis)
Peak in summer
31
Associated viruses
coxsackievirus, mumps, measles, adenovirus, and other viral infections (+)
32
GRANULOMATOUS THYROIDITIS (De Quervain thyroiditis) causes…. ….is effective in this damage.
tissue damage. secondary viral antigen or thyroid antigen stimulating cytotoxic T lymphocytes which damage follicle cells
33
Difference of GRANULOMATOUS THYROIDITIS (De Quervain thyroiditis) from autoimmune thyroid disease:
➢ The immune response is initiated by the virus ➢ Does not continue on its own ➢ Process is limited
34
GRANULOMATOUS THYROIDITIS (De Quervain thyroiditis) gross
➢ Unilateral or bilateral thyroid gland enlargement ➢ Hard yellow-white thyroid gland - adheres to surrounding tissue
35
Histological changes in GRANULOMATOUS THYROIDITIS (De Quervain thyroiditis) differ according to
the stage of the disease.
36
Histo Initial GRANULOMATOUS THYROIDITIS (De Quervain thyroiditis)
Follicular disruption and microabscesses
37
Advanced stage: GRANULOMATOUS THYROIDITIS (De Quervain thyroiditis) Histo
Plasma cells associated with damaged thyroid follicles, multinuclear giant cells (surround naked colloid pools or fragments)
38
Late stage: GRANULOMATOUS THYROIDITIS (De Quervain thyroiditis) Histo
Chronic inflammation and fibrosis
39
GRANULOMATOUS THYROIDITIS (De Quervain thyroiditis) clinical
• Pain • Thyroid enlargement • Transient inflammation and hyperthyroidism (ends in 2-6 weeks even without treatment) • Hypothyroidism • Time to return to normal thyroid function with recovery: 6-8 weeks
40
in granulomatius T3,T,TSH, iodine
( T3 T4⬆️ TSH ↓), radioactive iodine uptake↓ Hyperthyroidism
41
RIEDEL THYROIDITIS
Extensive fibrosis involving the thyroid and contiguous neck structures
42
Riedel manifests as
Diffuse, stony, and painless goiter
43
RIEDEL THYROIDITIS Age
Between 30-50 years old
44
Gender reidel thyroiditis
Female to man ratio:4:1
45
.. clinically mimics thyroid carcinoma.
RIEDEL THYROIDITIS
46
RIEDEL THYROIDITIS may be associated with fibrosis in other sites in the body Like
(retroperitoneal and mediastinal fibrosis, sclerosing cholangitis, pancreatitis
47
RIEDEL THYROIDITIs manifestes as
Initial euthyroid, then hypothyroid
48
RIEDEL THYROIDITIS is another manifestation of
a systemic autoimmune IgG4-related disease
49
LM OF RIEDAL
Lymphocytes, plasma cells(IgG4), a few eosinophils, neutrophil infiltration Extensive fibrosis, extraglandular involvement
50
Differential diagnosis: Of riedal
Sjögren Lymphoma Anaplastic carcinoma

305 Patho (1 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions