TLR And ILs

Question 1

TLR 1

Answer 1

Lipoprotein

Question 2

TLR 2

Answer 2

PEPTIDOGLYCAN

GPI on parasites when dimerized with TLR1

Or

Lipoteichoic Acid when dimerized with TLR 6

Question 3

TLR 6

Answer 3

Zymosan on yeasts

Question 4

TLR 3

Answer 4

dsRNA

Question 5

TLR 4

Answer 5

LPS

Question 6

TLR 5

Answer 6

Flagellin (receptor found in GI epithelium)

Question 7

TLR 7

Answer 7

ssRNA

Question 8

TLR 8

Answer 8

ssRNA

Question 9

TLR 9

Answer 9

Unmethylated CpG seen in bacteria and some viruses

Question 10

TNF

Answer 10

Source: Macrophages and T cells

Effect: activate inflammation in endothelium and neutrophils, fever via hypothalamus, apoptosis in some cells

Question 11

IL-1

Answer 11

Source: Macrophages, endothelial cells

Effect: activate endothelium, fever via hypothalamus

Question 12

IL-12

Answer 12

Source: Macrophages and DC

Effect: activate NK and T, INF-g synth, Th1 differentiation

Question 13

IFN-g

Answer 13

Source: NK and T

Effect: activate macrophages

Question 14

Type I IFN (alpha and beta)

Answer 14

Source: macrophages (alpha) and fibroblasts (beta)

Effect: anti-viral state, increase MHC I, activate NK

Question 15

IL-10

Answer 15

Source: Macrophages, Th2

Effect: atTENnuate, inhibit IL-12 production

Question 16

IL-6

Answer 16

Source: macrophages, endothelial, T cells

Effect: APP synthesis in Liver, B cell stimulation

Question 17

IL-15

Answer 17

Source: Macrophages

Effect: NK and T proliferation

Question 18

IL-18

Answer 18

Source: Macrophages

Effect: IFN-g synth from NK and T

Question 19

IL-8

Answer 19

Effect: Chemoattractant for neutrophils