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tolerance doses Flashcards

1
Q

what is the tolerance dose for the skin

A

55Gy

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2
Q

Dry Desquamation

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • skin
  • acute
  • 50Gy, 25#
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3
Q

Moist desquamation

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • skin
  • acute
  • 60Gy, 30 fractions
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4
Q

Hair loss

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • skin
  • acute
  • 20Gy, 10#
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5
Q

Atrophy, telangectasia, fragility, induration, ulcer

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • skin
  • Late
  • 55Gy, 25#
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6
Q

what is the tolerance dose to the lens of the eye

A

5Gy

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7
Q

Xeropthalmia

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • Lens of the eye
  • Sub-acute / late
  • 30Gy in 30#

Xeropthalmia is when the eye is unable to produce tears.

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8
Q

Decreased visual activity / blindness

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • lens of the eye
  • Late
  • 50Gy, 25#
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9
Q

Cataract

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • lens of the eye
  • late
  • 10Gy, 5#
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10
Q

what is the tolerance dose of the ears and tongue

A

60Gy

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11
Q

otitis media

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • Ears and Tongue
  • acute
  • 30Gy in 15#

otitis media is an ear infection

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12
Q

Loss of taste

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • ears and tongue
  • acute / sub-acute
  • 30Gy, 15#
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13
Q

Deafness

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • ears and tongue
  • Late
  • <60Gy, 30#
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14
Q

what is the maximum dose for the mouth, salivary glands

A

60Gy

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15
Q

decreased saliva

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • mouth, salivary glands
  • acute / sub-acute
  • 20Gy, 10#
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16
Q

Acute painful salitis

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • mouth, salivary glands
  • acute
  • 10Gy, 5#
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17
Q

Painful mucositis

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • mouth, salivary glands
  • acute
  • 40Gy, 20#
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18
Q

Permanent xerostomia

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • mouth, salivary glands
  • late
  • 50Gy, 25#

Permanent xerostomia - no saliva present in the salivary glands

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19
Q

Mucosal ulcer, severe fibrosis

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • mouth, salivary glands
  • Late
  • 60Gy, 30#
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20
Q

what is the tolerance dose of the larynx

A

65Gy

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21
Q

Persistent oedema, cartilage necrosis.

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • Larynx
  • sub-acute / late
  • 65Gy, 33#
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22
Q

what is the tolerance dose of the lung

A

30Gy (45Gy partial volume)

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23
Q

Pneumonitis

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • lung
  • sub-acute
  • 20Gy, 10#
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24
Q

Pulmonary fibrosis

  • What organ does it affect?
  • Is the side effect acute, sub-acute or late?
  • At what dose does this side effect occur?
A
  • Lung
  • Late
  • 30Gy
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25
What is the tolerance dose to the heart
40Gy
26
# pancarditis, pericarditis * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* heart * sub-acute * 40Gy, 20#
27
# pericardial stricture/effusion, mycardiopathy * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* heart * late * 45Gy, 23#
28
what is the tolerance dose of the stomach and bowel
45Gy
29
# Procitis with tenesmus * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* stomach and bowel * acute * 40Gy in 20# | procitis with tenesmus - inflamation and damage of the bowel
30
# Diarrhoea * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* stomach and bowel * acute * 20Gy in 10#
31
# Procitis with bleeding * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* stomach and bowel * acute * 50Gy in 25#
32
# strictures, ulcers, performation, fistulas * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* stomach and bowel * late * 45Gy in 23#
33
what is the tolerance dose of the rectum
40Gy or 60Gy with limited volume
34
what is the tolerance dose of the oesophagus
45Gy
35
# oesophagitis * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* oesophagus * acute * 30Gy in 15#
36
what is the tolerance dose of the liver
30Gy
37
# Hepatitis * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* Liver * Sub-acute * 25Gy in 12# | Hepatitis - inflammation of the liver.
38
# Liver failure, ascites * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* Liver * Late * 35Gy in 18# | Ascites - build up of fluid in the abdomen
39
What is the tolerance dose of the kidneys
1/3 each kidney 40Gy
40
# Nephritis * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* kidneys * sub-acute * 20Gy in 10# | Nephritis - inflammation of the kidneys
41
42
# Hypertension * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* kidneys * sub-acute / late * >20Gy in 10#
43
# stricture with obstruction * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* kidneys specifically the ureters * late * 75Gy in 38# | stricture - narrowing of the urethra
44
What is the tolerance dose of the bladder
60Gy
45
# cystitis * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* bladder * acute * 40Gy in 20# | urinary tract infection
46
# chronic cystitis, ulcer, contracture * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* bladder * late * 65Gy in 33# | contracture - shortening of muscle, tendons, skin etc...
47
# Impotence * What area does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* prosate * sub-acute / late * 60Gy in 30#
48
# Ulcer, Fistula * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* Vagina * Late * 90Gy in 45#
49
# Necrosis and perforation * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* uterus * late * >100Gy in 50#
50
# Hypopituitarism * What gland does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* Pituitary gland * Late * 45Gy in 23# | Hypoptituitarism - the pituitary gland does not make enough hormones.
51
# Hypothyroidism * What gland does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* thyroid gland * late * 45Gy in 23#
52
# Hypoadrenalism * What gland does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* adrenal glands * late * 60Gy in 30#
53
What is the tolerance dose of the gonads
3Gy
54
# Sterility, temporary amenorrhoea * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* gonads * acute / sub-acute * 3Gy | Amenorrhoea = absence of menstruation
55
# sterility, permanent amenorrhoea * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* gonads * late * 15Gy
56
What is the tolerance dose of the brain (including optic nerve)
50Gy
57
# Necrosis * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* Brain (including optic nerve) * late * 55Gy in 25#
58
What is the tolerance of the brain stem
45Gy
59
what is the tolerance dose of the spinal cord
44Gy in 10cm length
60
# L'Hermitte's syndrome * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* spinal cord * sub-acute * 45Gy in 23#
61
# Transverse Myelitis * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* Spinal cord * Late * 50Gy in 25# | Transverse myelitis - inflammation of the spinal cord
62
# Lymphoedema * What system does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* lympthics system * Late * 50Gy in 25#
63
# Atrophy and Induration * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* Breast * Late * 50Gy in 25#
64
# Atrophy * What does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* muscles * Late * >100Gy in 50#
65
# Necrosis and fracture * What does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* bone and cartilage * Late * 60Gy in 30#
66
What is the tolerance dose of bone and cartilage
60Gy
67
# Leukopaenia, thrombocytopenia * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* bone marrow * Acute * Dependent on location, site and dose
68
# immunodeficiency * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* bone marrow * acute / sub-acute * dependent on location, site and dose
69
# Marrow hyperplasia * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* Bone marrow * Late * 20Gy in 10# | Proliferation of hyperplastic haematopoietic marrow.
70
# Leukaemia * What organ does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* Bone marrow * late * dependent on location, site and dose
71
# Foetal death * What does it affect? * Is the side effect acute, sub-acute or late? * At what dose does this side effect occur?
* foetus * Acute / Sub-acute * 2-2.5Gy
72
when do acute side effects typically occur
occur during radiotherapy or a couple of weeks after.
73
when do sub-acute side effects typically occur
occur during 2-6 months after radiotherapy
74
when do late side effects typically occur
occur several months to years after radiotherapy

Tolerance doses radiotherapy (1 decks)

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