Topic 1 - Lifestyle, Health and Risk Flashcards

(53 cards)

1
Q

Open circulatory system

A

Consists of a heart, fluid and large cavity.
e.g. insects
The heart pumps blood into cavities that surround organs. Substances are able to diffuse between blood and cells. When the heart relaxes, blood is moved into the heart from the cavity through small, valved spaces.

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2
Q

Closed circulatory systems

A

Where blood is enclosed in blood vessels.
Generates higher blood pressure, forcing blood along narrow vessels instead of large cavities. Therefore the blood travels quicker and is more efficient at delivering substances to places in the body.
e.g. vertebrates
heart -> arteries -> aterioles -> capillaries -> venules -> veins -> heart

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3
Q

Single circulatory systems

A

The heart pumps deoxygenated blood to the gills.
Gaseous exchange happens in the gills - diffusion of CO2 from blood into the water surrounding the gills, and diffusion of O2 from the water to the blood into the gills.
e.g. fish

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4
Q

Double circulatory systems

A

Right ventricle pumps deoxygenated blood to the lungs where it is given O2.
The oxygenated blood travels back to the heart to be pumped (a second time) by the left ventricle into the body.
The blood flows through the heart twice for each full circuit of the body.
e.g. birds and mammals

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5
Q

Mass flow

A

Blood moves because of mass flow.
Movement of fluid down a pressure gradient (in one direction), through blood vessels, from a high pressure to low pressure.
Allows organisms to maintain their metabolic rate because it makes sure there is fast delivery of respiratory substances.

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6
Q

Why larger organisms need a closed circulatory system

A

To overcome diffusion limitations - diffusion isn’t sufficient on its own for oxygen/glucose transport.

SA:V ratio - larger organisms have a smaller SA:V ratio, meaning substances aren’t able to be diffused in fast enough.

Metabolic rate - larger organisms have a higher metabolic rate so require quicker delivery of substances.

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7
Q

What blood is and its functions

A

A specialised transport transport medium.
Functions:
- transport
- immunity/defence
- thermoregulation
- maintaining pH of bodily fluids

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8
Q

Composition of blood

A

Cells - 45%:
- RBCs - transport oxygen
- WBCs - immunity
- Platelets - blood clotting

Plasma - 55%:
- Water
- Proteins
- Ions
- Nutrients
- Waste products
- Hormones
- Gases

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9
Q

Water and electronegativity

A

Water = a polar molecule.
Electronegativity is the level of which atoms attract electrons in a covalent bond.
Electronegative is a high tendency to pull electrons.

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10
Q

Intermolecular bonding

A

Polar molecules form hydrogen bonds form between molecules.

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11
Q

Why water is a liquid

A

Has negative oxygen ends and positive hydrogen ends (dipole).
This allows each molecule to bond to another molecule through weak hydrogen bonding.

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12
Q

Waters traits - Good solvent

A

Water attracts/dissolves polar solute.

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13
Q

Waters traits - High specific heat capacity

A

Organisms need to keep a constant temperature.
The hydrogen bonds in water need a lot of energy to break.

Specific heat capacity - how much energy needed to raise the temperature of 1cm3 of volume by 1 degree celsius’s.

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14
Q

Waters traits - High tension

A

Hydrogen bonds are weak, but there are lots in water, which produces cohesion and tension.

Cohesion - weak hydrogen bonds hold water together.
Adhesion - water binds to different surfaces.
Tension - if one molecules moves, all of them move.

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15
Q

Valves of the heart

A

Atrioventricular valves - separate atrium and ventricle. also called tricuspid (right) and bicuspid (left) valves.
Semilunar valves - prevents the backflow of blood from the arteries into the ventricles.

Valves - prevent the back flow of blood.

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16
Q

Blood vessels

A

Arteries have thicker walls, narrowser lumen, more collagen and more smooth muscle with elastic fibres.

Veins have thinner walls, wider lumen, less collagen and less smooth muscle with elastic fibres. They also have valves.

Capillaries have one cell thick walls, no valves, collagen or smooth muscle. They have narrow lumen and are porous.

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17
Q

Using a stage micrometer and eyepiece graticule

A
  1. Line up eyepiece with stage micrometer. (1mm = 1000µm)
  2. Count the number of eyepiece units that are in 1000 µm. e.g. five eyepiece units in 1000 µm.
  3. Work out the length of one eyepiece unit in µm. e.g. 1000 µm ÷ 5 = 200 µm
  4. Take away the stage micrometer.
  5. Use the calculation to measure the width of the artery. e.g. if the width is twelve eyepiece units, the calculation is 12 x 200 = 2400 µm
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18
Q

Microscopy

A
  1. Set the objective lens to the lowest magnification. (x4)
  2. Use stage controls to move the slide across the stage until the light is shining through the specimen.
  3. Focus using the coarse focus.
  4. Adjust the focus using fine focus.
  5. Increase the objective lens magnification.
  6. Refine the image using the fine focus.
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19
Q

Cardiac cycle - Cardiac diastole

A

All the chambers are relaxed, allowing blood to flow into the heart.

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20
Q

Cardiac cycle - Atrial systole (Ventricular diastole)

A

The left atrium contracts, which increases pressure in the atria, forcing blood into the ventricles. AV valves are open - due to pressure being higher in the atrium than the ventricle.

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21
Q

Cardiac cycle - Ventricular systole (Atrial diastole)

A

The atria relax and the left ventricle contracts, increasing the pressure in the ventricle. AV valves are shut. Ventricle keeps contracting, forcing blood into the aorta. SL valves open.

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22
Q

Heart Attack

A

Myocardial Infarcation.
Lack of oxygen to heart tissue.
Leads to tissue damage or death.

23
Q

Stroke

A

Lack of oxygen to brain tissue.
Leads to tissue damage or death.

24
Q

Aneurysm

A

Swelling of an artery.
Can burst, the blood loss can be fatal.

25
Atherosclerosis - What is it
Fatty deposits/plaque build up inside of the arterial wall. Happens over decades. 6 step process.
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Atherosclerosis - 6 step process - Step 1
Endothelial damage in the artery: Damage to the inner layer of the artery. Caused by: - high cholesterol levels - toxins - constant high blood pressure Inflammatory Response: 1. Cholesterol meets at the injury site. 2. The cholesterol oxidises, triggering an immune response. 3. WBCs gather and result in inflammation inside the artery.
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Atherosclerosis - 6 step process - Step 2
Fatty Streak: A yellow streak is formed by dead cells at the site where there is endothelium damage. This streak is the start of plaque formation.
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Atherosclerosis - 6 step process - Step 3
Plaque growth and fibrous cap: More cells and debris accumulate at the yellow (fatty) streak, making the plaque bigger. The artery’s smooth muscle cells layers create a fibrous cap preventing parts breaking off into the bloodstream.
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Atherosclerosis - 6 step process - Step 4
Atheroma: Build up of plaque in the arterial walls. As the plaque gets bigger, calcium is added to make it harder.
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Atherosclerosis - 6 step process - Step 5
Rupture: The fibrous cap breaks apart, which triggers a blood clot, blocking the blood flow in the artery.
31
Atherosclerosis - 6 step process - Step 6
Rupture: The fibrous cap breaks apart, which triggers a blood clot, blocking the blood flow in the artery.
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Blood Clotting (Thrombosis) - What is it
Prevents excessive blood loss, the entry of pathogens and produces a barrier under which a wound can heal. A break in the skin membranes causes molecules to be released, triggering a chemical cascade and resulting in blood clotting.
33
Blood Clotting Process
1. Damage to endothelium of blood vessel. 2. The damaged blood vessel releases thromboplastin, which is a protein. 3. Calcium ions and vitamin k from the plasma, as well as thromboplastin, starts the conversion of soluble prothrombin protein into the enzyme thrombin. 4. Thrombin catalyses the reaction that converts soluble protein fibrinogen into the insoluble protein fibrin. 5. Fibrin fibres form a mesh and become tangled together, which traps platelets and red blood cells. 6. This forms a blood clot.
34
Correlation and Causation
Identifying correlation -> numerical data can show a correlation. Identifying causation -> can only be done if there is evidence of a biological relationship between two variables, usually in the form of an explanation of how a variable impacts the other.
35
Perception of risk
Risk -> the probability that a harmful event will happen. The statistical chance of a harmful event happening has to be supported by scientific evidence that is gained from research.
36
Perception of risk - How risk can be overestimated or underestimated
Risk can be overestimated due to factors like: - misleading information in the media - overexposure to information -personal experience of the associated risk - unfamiliarity of the event - the event causing extreme harm Risk can be underestimated due to factors like: - lack of information - misunderstanding of factors that can increase the risk - lack of personal experience of the associated risk
37
Using standard deviation
Calculate the range of values that are indicated by the ±. Compare the range of values for each and if there is any overlap, then there is no significant difference between the data sets.
38
Carbohydrates
Contain carbon, hydrogen and oxygen. General formula = CnHnOn Three types of carbohydrates (based on structure): Monosaccharides - specific definition for carbohydrate subunit. a type of sugar that can’t be broken down into a simpler sugar. e.g. glucose Disaccharides - two subunits joined together. a sugar that is formed when two monosaccharides are joined together by glycosidic bonds. e.g. lactose Polysaccharides -specific term for carbohydrate polymer. a carbohydrate made up of long chains f monosaccharide units joined together by glycosidic bonds.
39
Starch - Amylose and Amylopectin
Amylose: - polymer of alpha glucose - 1,4 glycosidic bonds - straight-chain molecule - forms helical structure, which is ideal for storage of starch in plant cells insoluble, has no osmotic effect on the cell Amylopectin: - polymer of alpha glucose - 1,4 and 1,6 glycosidic bonds - highly branched molecule - branched structure, lots of terminal glucose molecules useful for rapid hydrolysis to release glucose for respiration - insoluble, has no osmotic effect on the cell Amylopectin
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Lipids - Functions
Energy source = 38 kJ/g. Stored as adipose (fat) tissue. - thermal insulation - insulation of nerves - protection of organs
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Fatty acids
A hydrocarbon chain of varying length with a carboxylic acid group at an end.
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Difference between unsaturated and saturated fatty acids
Saturated fatty acids have no double bonds between the carbon atoms, whereas unsaturated fatty acids do have at least one double bond between the carbon atoms, which causes a kink in the chain. Saturated fatty acids have single bonds between carbon atoms, which means they are “saturated” with hydrogen atoms.
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State at room temperature - Lipids
Saturated lipids: - high intermolecular forces between triglycerides - solid at room temperature Unsaturated lipids: - low intermolecular forces between triglycerides due to kinks in fatty acids tails caused by double bonds between carbon atoms - liquid at room temperature
44
Energy budgets
How much energy is taken in compared to how much energy used by the body. BMR (Basal Metabolic Rate) = number of calories needed to keep your body functioning at rest. Your personal BMR can be impacted by height, mass, sex, age.
45
Obesity indicators
BMI: - people with a BMI over 30 are classified as obese - higher risk of high blood pressure and therefore atherosclerosis Waist-to-hip ratio: - takes into account abdominal fat - positive correlation between ratio and CVD risk
46
Cholesterol
Lipid. Needed for: - cell membranes - manufacture of growth hormones - sex hormones - bile salts for digesting fats
47
Cholesterol - Lipoproteins
Cholesterol is non-polar so it is insoluble in water/bloodstream. Transported in lipoproteins. Two types of cholesterol: - Low density lipoproteins (LDL) - High density lipoproteins (HDL)
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Cholesterol - LDLs
LDLs: - saturated lipids, protein and cholesterol - bind to cell receptors and are moved up by cells - excess LDLs overload cell receptors and saturated fats reduce the activity of receptors - leads to high blood cholesterol levels
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Cholesterol - HDLs
HDLs: - unsaturated lipids, protein and cholesterol - take cholesterol to liver where it is broken down - blood cholesterol is lowered - fatty plaques of atherosclerosis are removed
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Anti-hypertensives
Lower blood pressure. Some side effects include: - dry cough - high levels of potassium in the blood - extreme tiredness or dizziness from low blood pressure - headaches
51
Statins
Reduce blood cholesterol levels. Some side effects are: - headaches - dizziness - nausea - diarrhea
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Anticoagulants
Type of blood thinner that slows down the process of thrombosis/help prevent blood clots. Some side effects are: - diarrhoea - heartburn - nausea - loss of appetite - excessive bleeding
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Platelets inhibitors
Block substances hat help clots stick together and inhibit the formation of thrombin. Side effects include: - shortness of breath - haemorrhage - diarrhoea - nausea