Topic 1 - Lifestyle/health + Risk Flashcards

(84 cards)

1
Q

Open circulatory system

A
  • Blood circulates in open spaces.
  • Simple heart pumps blood into cavities surrounding organs.
  • Substances can diffuse between blood and cell.
  • Heart relaxes, blood drawn back in.

Eg insects.

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2
Q

Closed circulatory system

A
  • Blood flows in narrow tubes called blood vessels, generating high bp.
  • Faster transport means more efficiency in transporting blood around larger organism.

Eg mammals.

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3
Q

Single/double circulatory system

A

Single: Blood flows once through the heart per each complete circuit of the body. Eg fish.

Double: Blood flows through the heart twice for each complete circuit. Eg humans.

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4
Q

Properties of blood vessels

A

Collogen containing walls, strong fibrous protein. Allows them to withstand pressure.

Elastic fibers. Allows vessel to stretch and recoil. Maintaining blood pressure during diastole.

Smooth walls. Allows vessel to constrict and dialate, less friction between vessel and blood = efficient flow.

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5
Q

Arteries

Transport oxygenated blood under high pressure away from the heart - except pulmonary artery

A
  • Narrow lumen
  • thick walls, more collogen can withstand high pressure
  • Elastic fibers that allow the artery to recoil behind blood during diastole forcing it forward
  • Smooth walls that can constrict and dilate, maintain bp
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6
Q

Veins

Transport deoxygenated blood to the heart under low pressure - except for pulmonary vein

A
  • Narrow lumen
  • Thin walls, less collogen
  • elastic fibers and smooth walls
  • Valves, as they fill with blood they close preventing backflow of blood.
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7
Q

Cardiac cycle - Stage 1

Atrial systole

A

Blood flows into the left and right atria under low pressure from the pulmonary vein (from lungs) and vena cava (from body).

Artria fill with blood forcing AV valves open, blood leaks into ventricles. Atria contract (systole) forcing more blood into the ventricles.

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8
Q

Cardiac cycle - Stage 2

Ventricular systole

A

Ventricles contract increasing pressure in ventricles, forcing open semi-lunar valves.

Blood pushed out of aorta and pulmonary artery.

Pressure of blood against AV valves closes them preventing back flow of blood into the atria.

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9
Q

Cardiac cycle -Stage 3

Cardiac diastole

A

Atria and ventricles relax, elastic recoil of heart muscles lowers pressure in atria and ventricles.

Blood under high pressure in the aorta and pulmonaty artery is drawn back closing SL valves as they fill with blood.

Coronary arteries fill up during diastole. Low pressure helps draw in low pressure blood from veins.

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10
Q

Atherosclerosis

A

1) The endothelium lining of an artery gets damaged causing an inflammatory response, white blood cells are sent to the site.
2) Cells gather chemicals from the blood, particularly cholesterol. These cause a build up of fatty deposits known as an atheroma.
3) calcium salts and fibrous tissue build up at the site = plaque. Plaque hardens causing artery to lose elasticity.
4) Plaque causes lumen to narrow restricting blood flow thus increasing bp.
5) Positive feedback as high bp increases chance of plaque to form and further damage to occur.

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11
Q

Atherosclerosis

Cause + effect

A

Cause: High bp/high cholesterol

Effect:

  • Coronary arteries blocked = heart attack
  • Arteries supplying blood to brain blocked = stroke
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12
Q

Blood clotting

A
  • Blood clots seal break in blood vessels, prevent blood loss and pathogens entering
  • When in contact to damaged vessel they turn from flat discs -> spheres with long projections
  • Allows them to stick together and each other = temporary platelet plug.

Clotting cascade of changes results in a blood clot

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13
Q

Clotting cascade

A

1) Platelets and damaged tissue release protein -> Thromboplastin
2) This activates enzyme that catalyses conversion of protein prothrombin into enzyme thrombin, vitamin K + Calcium ions must also be present for this to occur
3) Thrombin catalyses conversion of soluble plasma protein fibrogen into insoluble plasma protein fribin
4) Tangled mesh of fibrin traps more platelets and blood cells
5) Clot forms and artery narrows

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14
Q

Hypertension

A

Another word for high blood pressure, causes friction between blood vessels and blood

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15
Q

Aneurysm

A

Artery get blocked by blood clot/plaque

Blood builds up behind clot

Artery bulges and becomes weaker

Increases chance of wall splitting open, internal bleeding

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16
Q

Coronary artery

A

An artery supplying blood to the heart

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17
Q

Coronary diseases

A

Angina: chest pain. When artery narrows less O2 can be supplied to the muscles, including heart.

Myocardial infarction: heart attack. When artery is fully blocked the heart becomes ischemic (without blood). The heart can be permanently damaged.

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18
Q

Symptoms of coronary disease

A
  • Shortness of breath
  • Angina (own symptoms: intense chest/shoulder pain
  • fatigue
  • burning behind breastbone
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19
Q

Arrhythmia

A

Irregular heart beats

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20
Q

Stroke

A

Blood flow to the brain is disrupted by blood clot/plaque.

If brain is starved of O2 for even a few minutes permanent damage could be caused

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21
Q

Symptoms of stroke

A
  • Numbness
  • Dizziness
  • slurred speech
  • Blurred/loss of vision
  • Paralysis of one side or the body
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22
Q

Capillaries

A

One endothelial cell thick

Narrow lumen, only big enough for one red blood cell

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23
Q

Water as an ideal transport medium

A
  • Liquid at room temp

- Slightly positive charge on one end, negative on the other = Dipole nature

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24
Q

Water as an ideal transport medium

Solvent properties

A
  • Allows other dipole natured molecule to dissolve in it, vital for bio-chemical reactions in cell
  • Molecules free to move in the aqueous environment can react with water : Hydrolysis/condensation
  • dissolved molecule can be transported in blood/lymph systems (humans) and Xylem/phloem (plants)
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25
Water as an ideal transport medium Thermal properties
- High specific latent heat capacity - Many hydrogen bonds require lots of energy to break - allows organism to maintain steady internal temp even when external conditions change
26
Risk
Probability of an unwanted outcome/event occurring. Usually in the context of hazards: anything that can potentially cause harm
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Absolute risk
How likely you are to develope a disease over time. Found by dividing the number of disease cases in pop by total pop
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Relative risk
Probability as a % increase or decrease relative to a changed factor. Eg exercise decreases risk of CVD
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Underestimating risk
- Risk is voluntary - Risk is natural - risk is fair - consequences of risk are in the long-term
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Overestimating | risk
-risk is forced -risk is unknown -risk is unfair Consequenxes are in the shor-term
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Factors affecting health risk
``` Age Heritage Social environment Physical environment Lifestyle abd behavour choices Diet ```
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Correlation Casual link
Correlation: when change in one variable affects the other Causal link: when one change in a variable cause a direct change in the other variable
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Cohot study
Large group of people are followed over a long tjme to see who does and does not develop the disease of study One group, no one has disease at the start. Those who do and don't develop disease are compared OR One group is exposed to risk factkrs and one is not Results are compared in a sum total at the end of the study
34
Case-control studiy
Group of people who have the disease are compared with a control who do not Risk factors they have been exposed to are assessed Diseased group + control group taken from well representing sample Histories are taken from each group Common risk factors are assessed and analysed to determine why one group did not develop disease
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Good case study
``` Clear aim Representative sample Valid and reliable results Sample size Control over variables ```
36
List a few basic risk factors for CVD
- High Bp/cholesterol - Obesity - Genetic inheritance - Inactivity - Smoking
37
What is blood pressure (systolic+diastolic bp)
Bp is a measure of the hydrostatic force of blood against the walls of a blood vessel, generated by a pumping heart. Systolic bp: pressure found in arteries as heart contracts forcing blood into arteries Diastolic bp: lowest pressure found when ventricles relax
38
Measuring Bp
Sphygomomanometer is used, consists of: - Inflatable cuff that is wrapped around the upper arm - Manometer that measures pressure and stethoscope
39
when are 1st and 2nd Bp readings taken
1st: taken when bp is at systolic pressure in the artery that has been closed 2nd: taken when no sound can be heard this is the lowest pressure, diastole presssure
40
Bp equation
Systole ÷ diastole (mmHg) Norm between 140/100 systolic and 140/90 diastole
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Peripheral resistance
Contact between blood and walls of blood vessel which causes friction and impedes blood flow
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What happens to bp when artery or arteriole contracts
Vessel constricts Lumen narrows Resistance increases and Bp rises Opposite happens when the artery or ateriol relaxes
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Factors that constrict the vessel
Loss of elasticity due to age High salt diet Release of hormones like adrenaline
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Tissue fluid + odemia
1) Arterial end of capillary under high pressure 2) Forcing fluid and small molecules into gaps between capillary walls into intermolecular spaces (forming tissue fluid) 3) Tissue fluid drains into network of lymph capillaries which returns fluid to the blood via lymph vessel that empties in vena cava
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Carbohydrates
Sugar and starch are classified as carbohydrates Cx(H2O)n Carbohydrates store and provide energy
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Monosaccharides
(CH2O)n They contain 6 carbons = hexose sugars Ring of 5 Cs with 6th C projected above/below structure - Monosaccharides are easily absorbed + rapidly release energy - little or no change required before being used in respiration
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Fructose
- Found in fruit + some veg | - sweetness attracts animals helping fruit to reproduce
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Glucose
- Main sugar used in respiration - When starch or glycogen digests glucose is produced This can easily be absorbed and transported by blood stream
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Galactose
- Found as part of lactose - Shares same molecular formula as glucose C6H12O6 -OH groups on Carbon 1 and four are different compared to glucose
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Disaccharides
Two single units join in condensation reaction, water molecule released when two sugars join Glycosidic bonds formed between units, bonds can be broken through hydrolysis
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Sucrose
- Formed from glucuse and fructose - main form in which sugar is transported around a plant 1.4 glycosidic bond
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Maltose
- Formed from two glucose molecules - Disaccharide found when amylase breaks down starch 1.4 glycosidic bond
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Lactose
-Formed from glucose + galactose People with lactose intolerance can have hydrolised milk 1.4 glycosidic bond
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Why are starch and glycogen good energy stores
- Compact molecules - Low solubility in water - Do not affect conc of water in cytoplasm, do not affect osmosis
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Amylose
- Found in plants - 1.4 glycosidic bonds between adjacent glucose molecules - Position of bonds causes chain to coil into single chain
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Amylopectin
- A polymer of glucose but has branches and long chains - 1.6 and 1.4 glycosidic bonds - Found in plants
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Glycogen
- Used in bacteria fungi and animals as an energy store instead of starch - Polymer consists of glucose molecules - Multiple branches means easily hydrolised - 1.4 and 1.6 glycosidic bonds
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Cellulose
- Non-starch polysaccharide | - Found in plants, 1.4 glycosidic bonds forming long chains
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Lipids
Term used to describe fats and oils Provides double the energy that carbs Large amounts of energy can be stored in small masses Insoluble in water Lipids we eat = triglycerides made from 3 fatty acids and 1 glycerole Bond formed = ester bond, 3 ester bonds in each trigylceride Joined though condensation reaction
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Saturated fats
- Single C-C bonds - Hydrocarbon has MAX amount of hydrogen atoms - Straight saturated hydrocarbon chain = can be tightly packed - Strong bonds between trigluceride fatty acids = fat solid at rt
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Unsaturated fats
- One C=C between each fatty acid chain - Polyunsaturated fats have many double bonds causing kinks in hydrogen chains = cant be compact - Weak intermolecular forces of attraction due to kink = fat liquid at rt
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Cholesterol
Short lipid molecule essential for good health - Made in our liver from saturated fats - Found in diet (like egg) Insoluble cholesterol binds with proteins to form lipoproteins which can be transported in blood
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LDLs
Low density lipoproteins Main cholesterol carrier in blood Consists of: saturated triglyceride, cholesterol and protein Transported from the liver to blood, maintains cell membrane - circulates in blood till needed Excess LDL = higher blood cholesterol LDL cholesterol can be deposited in arteries forming atheromas
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HDLs
High density lipoproteins Reduces platelet aggression, lowers risk of cvd Consists of: unsaturated triglycerides, cholesterol and protein Transports cholesterol from blood to liver where its broken down Lowers blood cholesterol, prevents fatty plaques Higher % of protein compared to LDLs
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Saturated/unsaturated fats in diet
Saturated fats: increase both LDL and HDL cholesterol, increase LDL more Unsaturated fats: Increase both but greater decrease in LDL cholesterol, HDL:LDL ratio increases Low fat diets that avoid saturated fats reduce blood cholesterol, esspecially LDL
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DRVs
Dietry reference values Provide average nutrient requirements for men and women of different ages EAR - estimated average requirement LRNI - lower reference nutrient intake HRNI - higher reference nutrient intake
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Fats
Supply fat to diet but also essential fatty acids that body cannot synthesise Fat must be present in diet to avoid deficiency symptoms
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BMR
``` Basal metabolic rate, higher in: Men Heavy people Active people Young people ```
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BMI
Body mass index = Mass (kg) ÷ height ^2 (m) <20 = underweight 20 - 24.9 = healthy 25 - 29.9 = obese
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Waist:Hip
Waist circumference ÷ hip circumference = Waist:Hip Men shouldn't have a ratio above 0.9 Women shouldn't have a ratio above 0.85
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How are age and gender a risk factor of CVD
Risk is higher in men As arteries age they lose elasticity and are more prone to damage
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How is high salt intake a risk factor of CVD
High salt in diet causes kidneys to retain water, higher fluid levels in blood raises bp which is associated with CVD
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How can taking antioxidant reduce risk of CVD
Unstable radicals (atoms with an unpaired electron) can damage genetic material + enzymes, vitamins can protect against radical damage
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How is smoking a risk factor of CVD
Carbon monoxide from smoke binds to haemoglobin instead of Oxygen, heart pumps faster in order to supply enough O2 to cells. Nicotine causes adrenalin to be released, narrowing arteries and raising bp Chemicals in smoke can lead to atherosclerosis
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How is inactivity a risk factor of CVD
Moderate exercise helps keep a low bp, also increases HDL cholesterol without increasing LDL cholesterol Helps maintain healthy weight
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How is sudden exposure to stress a risk factor of CVD
Sudden exposure to stress releases adrenalin, which causes arteries to constrict - raising bp
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How is excessive alcohol intake a risk factor of CVD
Can increase weight/bp and cause irregular heartbeats , damages liver's ability to remove fats/lipids Moderate intake can increase HDL cholesterol
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Treatments for CVD - lifestyle changes
``` Stopping smoking moderate use of alcohol maintaining low bp maintaining healthy BMI Regular cardiovascular exercise ```
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Treatments for CVD - dietary changes
``` Reduced saturated fats More polyunsaturated fats Reduced cholesterol Reduced salt More non-starch polysaccharides More fruits and veg ```
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Treatments for CVD - lower cholesterol in diet
Plant sterols and stanols are found in yoghurt and margarines, they have a similar structure to cholesterol. Lowers blood cholesterol. best when consumed at recommended amounts.
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Treatments for CVD - how do statins reduce blood cholesterol
It blocks enzymes in liver that makes cholesterol and LDLs. Reduces inflammation of artery walls. Can cause dizziness, joint pain, liver damage, headaches and muscle inflammation.
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How do diuretics treat high bp
Increases amounts of urine made by kidneys reducing excess fluid and salt in the body. Leads to decrease in blood plasma volume and cardiac output therefor decreasing bp. Can cause: Dizziness Nausea Muscle cramps
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How does aspirin (Platelet inhibitory drug) reduce blood clots + side effects
Makes platelets less sticky, less able to form clots Side effects: Blood in urine Nose bleeds Heavy bleeding from cuts
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How does warfarin (anticoagulant) reduce blood clots + side effects
Prevents prothrombin being made in body, no clotting cascade Side effects: Sudden back pain Bleeding gums Difficulty breathing