Topic 12 Immune Response & Inflammation Flashcards
(129 cards)
The three major players in immunity
white blood cells
antibody
complement system
Antigen
anything foreign that enters the body
–can bind to antibody and/or can bind to receptors on the T or B cells
Target cells
antigenic cells that will be destroyed by immune system
Immunogene
any substance that can stimulate an immune response
all are antigenic (can bind with antibody)
not all antigens are immunogens
Pathogen
antigen with ability to cause disease
usually microorganism or toxin
Are all antigens immunogens?
No
any substance that can stimulate an immune response
Immunogene
Microorganisms
bacteria / viruses / parasites / fungi / yeasts
cells from genetically dissimilar individual
Allogeneic cells
Infected cells
cells inhabited by viruses / certain bacteria /
parasites
Antigen examples
Infected cells, microorganisms, allogeneic cells, malignant
Leukocytes normal count? per mL
Avg adult has 75 billion circulating WBCs
NORMAL COUNT: 5,000 to 10,000 per mL
Neutrophiles: % of total
40 to 75% of total
Lymphocytes: % of total
20 to 45%
–
T Cells / B Cells
Monocytes: % of total
Up to 8%
Eosinophils: % of total
1 to 6%
Basophils: % of total
Up to 1%
Most numerous, named for granules in cytoplasm
Granulocytes
What are 3 Granulocytes
Neutrophils
Basophils
Eosinophils
large white cells, become macrophages in body tissues
monocytes
differentiate into B-and T-cells
Lymphocytes
Where are Neutrophils made?
hematopoietic marrow
Neutrophils where are they in body? Circulate ?
50% circulate
50% adhere to blood vessel wall
–Margination
–Ready to move into tissues
Neutrophils function ?
phagocytosis