Topic 14

Question 1

Composition of bone contain 2 Parts?

Answer 1

• Cellular
• ECM

Question 2

Mention cellular parts of bone?

Answer 2

Cellular: osteoblast osteocyte osteoclast

Question 3

Function of osteoblast

Answer 3

I_produce ECM
2- mineralize ECM
3- Produce osteoid
4- Activation osteoclast
5- Production GH

Question 4

osteocyte is matured (?) in bony matrix.

Answer 4

OB

Question 5

osteoclast produce (?) with degrade (?)

Answer 5

Ht
Hydroxy-apatite

Question 6

ECM contain (?) and (?)

Answer 6

organic
inorganic

Question 7

mention organic part of ECM of bone cell?

Answer 7

Collagen Fiber type I
osteonectin
osteocalcin
proteoglycan
glycosaminoglycans
lipid

Question 8

inorganic Part of ECM of bone cell?

Answer 8

Hydroxyapatite

Question 9

biological principle of bone regeneration?

Answer 9

1- osteogenesis
2- osteo induction
3- osteo Conduction
(◦ steo. gig

Question 10

biological process for bone regeneration?

Answer 10

• Hematoma formation
• information and tissue replacement
• Callus formation (soft and Hard)
• Consolidation
• Bone Remodeling

Question 11

Hematoma formation 7

Answer 11

• mass of blood clot and hemmorhage at site of fracture.
• at this time site become swallower - painful_ inflamed.

Question 12

Hematoma formation? (

Answer 12

Question 13

2- information and tissue regeneration
happen in (?) and what cells coming?

Answer 13

• Next few hours.
• migration of mesenchymal stem cells.

Question 14

in Inflammatory phase after migration of mesenchymal cells
they produce (?) (?) (?)

Answer 14

• TGF-B
• PDGF
• various BMP factors

Question 15

PDGF full name and function?

Answer 15

• Planet derived Growth factor
• Stimulate cell cycle

Question 16

what is callus formation?

Answer 16

Fibro cartilaginous callus forms.

Question 17

Granulation tissue def?

Answer 17

Soft callus, forms a few days after fracture
at this time capillaries grow into the tissue and
phagocytic cells begin creating debris

Question 18

Granulation tissue is located at what level
of bone regeneration.?

Answer 18

phase of callus formation

Question 19

Consolidation phase?

Answer 19

in this stage, New bone trabecular appear
in the fibro cartilage nus callus.
Convert to bony callus occur in 3-4 weeks after
injury and antinous until firm union is formed
2-3 month-

Question 20

Regarding bone Remodeling?

Answer 20

in the final stage, excess material on the bone shaft
exterior and medullary canal is removed. here compact bone reconstruct
shaft wall.

Question 21

Remodeling and Modeling:
Remodeling happen in 2 times when?

Answer 21

1- During bone formation
2- replace old bone with New bone.

Question 22

in the Remodeling and during bone formation:
primary bone is substitute with Lamela/ bone.
what is primary bone?
what is La.me/ar bone?

Answer 22

• primary bone is woven bone ⇒ low load bearing
• high load bearing capacity.

Question 23

bone formation is done with osteoblast, vessel, and (?)

Answer 23

• pericyte.

Question 24

Exudative, proliferative phase: day ( ?)

Answer 24

• day 1-14

Question 25

formation of reticular bone:

Answer 25

- week 2-6

Question 26

formation of Lamelav bone and remodeling:

Answer 26

week 6-18

Question 27

what happen in Exudative. proliferative phase?

Answer 27

(primary stability) - bleeding: coagulum formation - Site become inflamed: mesenchymal_GF Secretion_granulation tissue Angiogenesis

Question 28

what happen at reticular bone phase (after week 2- 6)

Answer 28

- Mesenchymal: fibroblast osteoblast osteoclast

Question 29

what happen at lamellar bone phase?

Answer 29

Secondary stabilization mineralization increases_vascularization (woven bone)

Question 30

osteo conduction definition? limp I

Answer 30

the process in which the graft (Autograft- Allograft- ✗ enogivaft - alto plastic) creats a scaffold matrix to support bone attach and grow unit.

Question 31

osteo conduction def? (summitry)

Answer 31

- deposition + New bone formation

Question 32

(?) is important and crucial for vessel ingrowth and bone matrix deposition. and should be similar to normal bone as possible.

Answer 32

- proper structure and design (scaffold)

Question 33

allograft?

Answer 33

- processed humman bone (from one person to another)

Question 34

Autogenous bone graft?

Answer 34

- Patient own tissue.

Question 35

Xeno graft?

Answer 35

HA-Natural (Bio-OSS) from one species to another

Question 36

previous + here = material used. - synthetic poly ters - tri calcium phosphate - Bio glass ceramic

Question 37

osteo induction def

Answer 37

a process which include stem cells, differentiation into osteogenic cells in order to form bone by growth factor

Question 38

material used in 01 phase:

Answer 38

- demin bone matrix - bone morphogenic matrix protein - Growth factor injection - Gene therapy (from Auto. or Allograft)

Question 39

Growth factor acts on (?) and osteoblasts?

Answer 39

7. = Fibroblast.

Question 40

osteogenesis definition?

Answer 40

process providing stem cells with osteogenic potential which Lays down new bone.

Question 41

material use in osteogenesis?

Answer 41

ONLY autogenous bone grafts.

Question 42

N) combined process is?

Answer 42