Topic 1B: Local Control Blood Flow Flashcards
Tissue demand (4) “need and leave”
- Delivery oxygen & other nutrients
- Removal of waste (carbon dioxide & hydrogen ions)
- Maintain appropriate ion concentrations
- Supply needed hormones
demand within tissue will ___ over time
vary
How does changes in flow to one tissue impact the flow to all other tissues?
it must not impact flow to all other tissues
Control of Tissue blood flow wants what for the heart?
to keep work of heart as low as possible
BF % CO
Heart muscle
3%
BF % CO
Brain
14%
BF % CO
Skeletal Muscle inactive
15%
BF % CO
Bone
5%
BF % CO
GI/spleen
21%
BF % CO
liver
7%
BF % CO
kidney
22%
BF % CO
skin (cool)
6%
BF % CO
other
8%
BF % CO
Bronchi
2%
ml/min
muscle active
16,000 ml/min
80 ml/min/100gm tissue weight
Acute (metabolic control)
Sudden (seconds) changes in metabolism; oxygen content; input pressure
Finite response
Acute (metabolic control) controlled mainly by
Controlled mainly vasodilation / vasoconstriction of arterioles, metarterioles, precapillary sphincters
Long term (metabolic control)
More permanent changes in metabolism; oxygen content; input pressure
Almost infinite response
takes days/weeks
Long term (metabolic control) controlled by?
Controlled by increasing / decreasing physical size and number of blood vessels within tissue