Topic 2 - Integumentary System & Dermatology (Part 2) - Tutor Flashcards

(47 cards)

1
Q

What is the integumentary system?

A

The integumentary system includes the skin and its appendages, functioning to protect the body, regulate temperature, and provide sensory information.

The integumentary system plays a crucial role in overall health and is the body’s first line of defense against environmental hazards.

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2
Q

What is eczema also known as?

A

Atopic dermatitis

Eczema is a chronic inflammatory skin condition characterized by intense itching and inflammation.

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3
Q

What are the hallmark symptoms of eczema?

A
  • Dry skin
  • Pruritus (itching)
  • Redness
  • Swelling
  • Eruptions of pimple-like bumps (rash)
  • Feeling of warmth to the touch
  • Weeping rash (liquid bumps or blisters that break)

These symptoms can vary in severity and may disrupt the patient’s quality of life.

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4
Q

What is the atopic triad?

A
  • Atopic dermatitis
  • Asthma
  • Allergic rhinitis

The atopic triad refers to the common co-occurrence of these allergic conditions.

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5
Q

What percentage of school children and teenagers in Singapore are affected by eczema?

A

Up to 20.8%

This statistic highlights the prevalence of eczema among younger populations.

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6
Q

What are common trigger factors for eczema?

A
  • Excessive heat and sweating
  • Exercise
  • Infections
  • Rough fabrics
  • House dust mites
  • Stress
  • Allergens
  • Irritants (medicated soaps, detergents, bubble baths, grass)

Identifying and managing these triggers is essential for effective eczema treatment.

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7
Q

What are the treatment goals for eczema?

A
  • Control of symptoms
  • Maintain skin hydration
  • Reduction of flares
  • Prevent future exacerbations
  • Improvement in quality of life (QOL)

Achieving these goals helps manage eczema effectively and improves the patient’s daily life.

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8
Q

What types of medications are used in the pharmacology of eczema treatment?

A
  • Moisturisers
  • Topical corticosteroids
  • Antihistamines
  • Topical calcineurin inhibitors
  • Systemic immunosuppressants
  • Interleukin 4 receptor antagonists
  • Tar preparations

Each class of medication serves a specific purpose in managing eczema symptoms.

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9
Q

Fill in the blank: Eczema is a chronic skin disorder involving inflammation associated with intense _______.

A

pruritus

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10
Q

What is the initial mechanism that triggers inflammatory changes in eczema?

A

Unknown

The pathophysiology of eczema involves complex genetic interactions and environmental factors leading to skin barrier dysfunction.

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11
Q

What is the recommended frequency for applying moisturizers in eczema management?

A

A minimum of twice a day; optimal is 3-4 times a day

Regular application helps lock in moisture and prevent flare-ups.

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12
Q

What are non-pharmacological advice for managing mild eczema symptoms?

A
  • Continue non-pharmacological advice
  • Apply low to medium potency topical corticosteroids
  • Use antihistamine as needed for itch

Non-pharmacological approaches are essential for comprehensive eczema management.

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13
Q

True or False: Topical corticosteroids can be used for more than 2 weeks without medical supervision.

A

False

High potency topical corticosteroids should not be used for more than 2 weeks without supervision due to potential side effects.

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14
Q

What are the side effects of long-term use of topical corticosteroids?

A
  • Thinning of skin
  • Easy bruising
  • Reddish stretch marks
  • Acne

Awareness of these potential side effects is important for safe corticosteroid use.

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15
Q

What is the role of antihistamines in eczema treatment?

A

Intermittent use may help with sleep loss due to itching, particularly sedating antihistamines.

Antihistamines alone have little evidence for controlling pruritus in eczema.

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16
Q

What factors determine the choice of moisturizer for eczema?

A
  • Dryness of the skin
  • Area of skin involved
  • Patient comfort and acceptability

Selecting the right type of moisturizer is crucial for effective eczema management.

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17
Q

What is the main action of topical corticosteroids in eczema management?

A

Exert anti-inflammatory effects to manage symptoms like itch, redness, and swelling.

These medications help reduce the inflammatory response associated with eczema.

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18
Q

What is the recommended application frequency for topical corticosteroids?

A

Twice daily, but once daily application of moderate-to-potent TCS can be effective.

Proper dosing is critical to maximize benefits while minimizing side effects.

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19
Q

What should be avoided when using topical corticosteroids?

A
  • Applying on broken or infected skin
  • Long-term use without supervision

These precautions help prevent complications and ensure effective treatment.

20
Q

What is the risk associated with paraffin-based moisturizers?

A

They are flammable and should be used with caution near open flames.

Awareness of this risk is important for safe usage in everyday settings.

21
Q

What is the evidence regarding antihistamines in controlling pruritus in eczema?

A

There is little evidence that antihistamines alone are beneficial in the control of pruritus in eczema.

22
Q

Which sedating antihistamines may be beneficial for sleep loss due to itch in eczema patients older than 6 months?

A
  • Hydroxyzine
  • Chlorpheniramine
23
Q

What is a potential negative effect of sedating antihistamines like hydroxyzine and chlorpheniramine?

A

They may negatively affect school performance due to hangover effect.

24
Q

What is a less sedative antihistamine that may be warranted for patients experiencing sleep loss due to itch?

25
What is the usual dosing schedule for antihistamines?
Usually once a day, night dosing before sleep.
26
How is cetirizine classified in terms of forensic classification?
GSL
27
What is the forensic classification for chlorpheniramine?
Pharmacy Only
28
What is the forensic classification for hydroxyzine?
POM
29
What special counseling point should be considered when prescribing non-sedating and sedating antihistamines together?
This is not a therapeutic duplication as it is intentionally prescribed.
30
What is the mechanism of action (MOA) of topical calcineurin inhibitors?
Suppresses cellular immunity by inhibiting T-lymphocyte activation.
31
What is the dosing recommendation for topical calcineurin inhibitors?
Apply twice a day.
32
What are two examples of topical calcineurin inhibitors?
* Tacrolimus * Pimecrolimus
33
What is the place in therapy for topical calcineurin inhibitors?
Alternative to TCS for face as they do not cause skin thinning.
34
What are common side effects of topical calcineurin inhibitors?
* Transient burning * Erythema * Pruritis
35
What is the recommended short course of systemic glucocorticoids for eczema?
Prednisolone 40-60 mg/day for 3-4 days, then 20-30 mg/day for 3-4 days.
36
When is the use of systemic immunosuppressants indicated?
When topical therapy is inadequate and phototherapy is unavailable or contraindicated.
37
What is an example of an interleukin 4 receptor antagonist used in eczema treatment?
Dupilumab
38
What is the initial dose of dupilumab for patients weighing 15 to less than 30 kg?
600 mg (two 300 mg injections)
39
What is the subsequent dose of dupilumab for patients weighing 30 to less than 60 kg?
200 mg every other week.
40
What is the mechanism of action for tar preparations?
Act as disinfectants and astringents to help correct abnormal keratinization.
41
What is the place in therapy for tar preparations?
Adjunctive therapy used in combination with steroids and phototherapy.
42
What is the recommended method of application for topical creams/ointments?
Rub in/massage gently in a circular motion until the medicine disappears.
43
What is the appropriate amount of cream/ointment to apply over an area of two adult hands?
About one fingertip unit, which is approximately 0.5g.
44
What is the general order of application when using an emollient with a topical corticosteroid?
Apply emollient first and wait around 30 minutes before applying topical corticosteroid.
45
What are some non-pharmacological advice for managing eczema?
* Use hypoallergenic cosmetics * Avoid frequent and long baths * Apply moisturizers frequently
46
What dietary and lifestyle recommendations are suggested for eczema management?
* Eat a healthy diet * Drink plenty of water * Exercise regularly
47
Under what circumstances should a patient be referred to a doctor for eczema?
* Pus is present along with skin lesions * Severe condition with intense pruritis * Rash due to irritants