Topic 3 Organisms exchange substances. Mass transport Flashcards
(46 cards)
What is the structure of haemoglobin
globular, water soluble.
consists of four polypeptide chains each carrying a haem group (quaternary structure)
DEscribe the role of haemoglobin
present in red blood cells. oxygen molecules bind to haem groups and are carried around the body to where they are needed in respiring tissues
What is the affinity of haemoglobin for oxygen
ability of haemoglobin to attract or bind oxygen
what is the saturation of haemoglobin with oxygen
when haemoglobin is holding the maximum amount of oyxgen it can bind
what is loading/assosaitation of haemoglobin
binding of oxygen to haemoglobin
what is unloading dissociation of haemoglobin
when oxygen detatches or unbinds from haemoglobin
What does the oxyhaemoglobin dissociation curve show?
saturation on the side oxygen oartial pressure on the bottom of graph steady increase curve
oxygen is loaded in regoins with a high partial pressure of oxygen (e.g. alveoli) and is unloaded in regioins of low partial pressue of oxygen (respiring tissue). at a lower partial pressure haemoglobin has a lower affinity and as aresult will unload oxygen in those regions.
What is cooperative binding
the cooperative nature of oxygen binding to haemoglobin is due to the haemoglobin changing shape (confromational change) when the first oxygen binds) making it easier for further oxygens to bind. 3d structure slighty changes. explains steep curve on graph
What is the bohr effect
the bohr effect is when a high carbon dioxide concentration causes the oxyhaemoglobin curve to shift to the right. the affinty of oxygen decreases because the acidinc carbon dioxies changes the shape of haemoglobin slightly.
when partial pressue of carbon dioxide increases conditions become acidic causing haemoglovin to change shape. affinty decreases.
How does saturation of haemoglobin with oxygen affect oxygen haemoglobin binding
difficult for the first oxygen molecule to bnd. then it changes shape to make it easier for second and third. it is slightly harder for the fourth oxygen molecule to bind because there is a low chance of finding a binding site
how does partial pressure of oxygen affect oxygen haemoglobin binding?
as partial pressure of oxygen increases the affinity of oxygen also increases so oyxgen binds to haemoglobin. when partial pressure is low oxygen is relaesed from haemoglobin
Describe what the bohr effect would look like on a graph
line shift left:low partial pressue of carbon dioxide in alevoli curve shifts left increased affinty and therefore more oxygen uploaded
line shifts right: higher partial pressure of carbon dioxide at resporing tissues curve shifts right. decreased affinity and unloads more oxygen
Describe the oxihameoglobin disocciation curve for fetal haemoglobin
Foetal haemoglobin:shift to left of adults. even at same partial pressue of oxygen the curve has shifted so it has a higher affinity and is more saturated with oxygen.
higher affinity for oxygen advantaged because foetus cannot exhale and inhale. only source of oxygen is from the mothers haemoglobin via placenta
Describe llama and earthworm haemoglobin dissociation curve
llamas live at higher alitudes where there is a lower partial pressure of oxygen.
curve shifts to the left: higher affinity for oxygen. even at a low partial pressue high affintiy allows of effiecent oxgen saturation
earthworms live underground at lower partial presssure.
describe oxyhaemoglobin dissociation curve for dove
line on graph shifts to the right: lower/decreased affinity. mroe likely to unload oxygen at same partial pressure. advantageous due to faster metabolism so needs more oxygen for respiration to provide energy for contracting muscles.
Describe the propeties of the cardiac muscle and how it is myogenic
Thick muscular layer of the walls of the heart.
Myogenic meaning it can contract and relax without nervous or hormone stimulation,
It never fatigues as long as it has an oxygen supply.
Describe cornary arteries
Cornary arteries supply cardiac muscle with oxygenated blood
these branch off from the aorta
if they become blocked cardiac muscle wnt recieve oxygen therefore will not be able to respire and the cells will die (myocardial infarction) heart attack
Describe and name the four changes of the heart and their properties
Left atrium and right atrium
left ventricle and right ventricle
atria
have thin muscular walls.
because they do not need to contract as jard as they are only pumping blood to ventricles
elastic walls that stretch when blood enters
ventricles
have thick muscuar walls to enable bigger contraction
creates a high blood pressure to enable blood to flow longer distances (lungs and rest of body)
right ventricle thinner muscular wall compared to lefft as pumps blood to lungs at a lower pressure to prevent capillary damage and so blood flows slwoly allowing time for gas exchange
Describe arteries and veins in the heart and the movement of blood within them
arteries (away): pulmonary arteries (carries deoxygenated blood from the right ventricle to the lungs) and aorta (carries oxygenated blood from left ventricle to the rest of the body)
veins (in): pulmonary vein (oxygenated blood from lungs to left atrium) and venca cava(carried deoxyginate dblood from body into right atrium)
relate the structure of the vessels to their function
- arteries have thick walls to handle high pressure without tearing. muscular and elastic to control blood flow
- veins have thin walls due to lower pressure therefore requiring valves to ensure blood doesn’t flow backwards.
Describe and name the valves in the heart
semi-lunar valves: in aorta and pulmonary artery
atriventricular:between atria and ventricles
bicuspid:left side (two flaps)
tricuspid:right side (three flaps)
function:prevent back flow of blood. open when pressure is higher behind the valve. close when pressure is higher in front of valve
What is the function of the septum
septum separates deoxygenated and oxygenated blood in the heart.
maintains high concentration of oxygen in oxygenated blood t mainrain conc gradient to enable diffusion at repsiring cells
what are the three stages of teh caridac cycle
diastole
atrial systole
ventricular systole
Describe what happens during caridac diastole (cardical cycle)
The atria and ventricular msucles are relaxed.
blood enters atria increasing pressure in atria. pushing open atrioventricular valves. allowing blood to flow into ventricles.
pressure in the heart is lower than in arteries so semi lunar valves remain closed