topic 3B: mass transport in animals Flashcards
(37 cards)
Describe the role of red blood cells & haemoglobin (Hb) in oxygen transport
● RED BLOOD CELLS contain lots of HAEMOGLOBIN
○ NO NUCLEUS AND BIONCAVE → more space for haemoglobin, high SA:V & short diffusion distance
● haemoglobin ASSOCIATES with and BINDS loads of oxygen at GAS EXCHANGE SURFACES (lungs) where PARTIAL PRESUURE OF OXYGEN (pO2) is HIGH
● This forms OXYHAEMOGLOBIN which TRANSPORTS oxygen
○ Each can carry FOUR OXYGEN MOLECULE, one at each Haem group
● haemoglobin dissociates from / unloads oxygen near cells / tissues where pO2
is low
Describe the structure of haemoglobin
● PROTEIN with a QUATERNARY structure
● Made of 4 POLYPEPTIDE CHAINS
● Each chain contains a HAEM GROUP containing an IRON ION (Fe
2+)
The haemoglobins are a group of CHEMICALLY SIMILAIR molecules found in many different organisms
Describe the loading, transport and unloading of oxygen in relation to the
oxyhaemoglobin dissociation curve - Areas with low pO2 - respiring tissues
● Hb has a LOW AFFINITY for oxygen
● So oxygen readily UNLOADS and DISSACIOATES with haemoglobin
● So % saturation is LOW
Describe the loading, transport and unloading of oxygen in relation to the
oxyhaemoglobin dissociation curve - Areas with high pO2 - gas exchange surfaces
● haemoglobin has a HIGH AFFINITY for oxygen
● So oxygenreadily LOADS and ASSOCIATES haemoglobin
● So % saturation is HIGH
Explain how the cooperative nature of oxygen binding results in an
S-shaped (sigmoid) oxyhaemoglobin dissociation curve
- BINDIN of FIRST OXYGEN changes TERTIARY and QUATERNARY STRUCTURE structure of haemoglobin
- This UNCOVERS HAEM GROUP BINDING SITES, making FURTHER BINDING of oxygens EASIER
Describe evidence for the cooperative nature of oxygen binding
● A low pO2 as oxygen increases there is a SMALL INCREASE IN % SATURATION of haemoglobin with oxygen
○ When first oxygen is binding
● At higher pO2, as oxygen increases there is a BIG RAPID INCREASE in % SATURATION of haemoglobin with oxygen
○ Showing it has got easier for oxygens to bind
Explain effect of CO2 concentration on the dissociation of oxyhaemoglobin
- Increasing blood CO2 eg. due to increased rate of RESPIRATION
- LOWERS blood pH (more acidic)
- REDUCING Haemoglobin’s AFFINITY for oxygen as the SHAPE and tertiary / quaternary structure changes slightly
- So MORE and FASTER UNLOADING of oxygen to respiring cells at a given pO2
What is the Bohr effect?
Effect of CO2 CONCENTRATION on dissociation of oxyhaemoglobin → curve shifts to RIGHT
Describe evidence for the Bohr effect
At a given pO2 %, the SATURATION of haemoglobin with oxygen is LOWER
Explain the advantage of the Bohr effect (eg. during exercise)
More dissociation of OXYGEN → faster AEROBIC RESPIRATION and less anaerobic respiration → more ATP produced
Explain why different types of haemoglobin can have different oxygen
transport properties
● Different types of Hb are made of polypeptide chains with slightly DIFFERENT AMINO ACID SEQUENCES
● Resulting in different TERTIARY AND QUATERNARY STRUCTURES and shape
● So they have different AFFINITIES for oxygen
Explain how organisms can be adapted to their environment by having
different types of haemoglobin with different oxygen transport properties - Curve shift left
Hb has higher affinity for O2
● MORE O2 ASSOCIATES with Haemoglobin MORE READILY
● At GAS EXCHANGE SURFACES where pO2
is LOWER
● Eg. organisms in LOW O2 environments - HIGH ALTITUDES, UNDERGROUND OR FOETUSES
Explain how organisms can be adapted to their environment by having
different types of haemoglobin with different oxygen transport properties - Curve shift RIGHT Haemoglobin has LOWER affinity for O2
● MORE O2 DISSOCIATES from haemoglobin MORE READILY
● At RESPIRING TISSUES where more O2
is needed
● Eg. organisms with HIGH RATES OF RESPIRATION AND METABOLIC RATE (may be small or active)
Describe the general pattern of blood circulation in a mammal
CLOSED DOUBLE CIRCULATORY SYSTEM - blood passes through heart TWICE for every circuit around body:
1. DEOXYGENATED blood in RIGHT side of heart pumped to LUNGS; oxygenated returns to left side
2. OXYGENATED blood in LEFT side of heart pumped to REST OF BODY; deoxygenated returns to right
Suggest the importance of a double circulatory system
● Prevents MIXING of OXYGENATED AND DEOXYGENATED blood
○ So blood pumped to body is FULLY SATURATED with oxygen for AEROBIC RESPIRATION
● Blood can be pumped to body at a HIGHER PRESSURE (after being lower from lungs)
○ Substances taken to / removed from body cells QUICKER AND MORE EFFICIENTLY
Name the blood vessels entering and leaving the heart and lungs
● VENA CAVA – transports deoxygenated blood from respiring body tissues → heart
● PULMONARY ARTERY – transports
deoxygenated blood from heart → lungs
● PULMONARY VEIN – transports oxygenated blood from lungs → heart
● AORTA – transports oxygenated blood
from heart → respiring body tissues
Name the blood vessels entering and leaving the kidneys
● RENAL ARTERIES – oxygenated blood → kidneys
● RENAL VEINS – deoxygenated blood to vena cava from kidneys
Name the the blood vessels that carry oxygenated blood to the heart muscle
CORONARY ARTERIES - located on surface of the heart, branching from aorta
Suggest why the wall of the left ventricle is thicker than that of the right
● Thicker muscle to CONTRACT with greater force
● To generate HIGHER PRESSURE to pump blood around ENTIRE BODY
Explain the pressure & volume changes and associated valve movements
during the cardiac cycle that maintain a unidirectional flow of blood - Atrial systole
● Atria CONTACT and ventricles relax
● So their volume DECREASES,
pressure INCREASES
● ATRIOVENTRICULAR VALVES OPEN
when pressure in ATRIA EXCEEDS pressure in VENTRICLES
● SEMILUNAR VALVES remain SHUT
as pressure in ARTERIES EXCEEDS pressure in VENTRICLES
● So blood pushed into VENTRICLES
Explain the pressure & volume changes and associated valve movements
during the cardiac cycle that maintain a unidirectional flow of blood - Ventricular systole
● Ventricles CONTRACT
● So their volume DECREASES,
pressure INCREASES
● ATRIOVENTRICULAR VALVES SHUT
when pressure in VENTRICLES EXCEEDS pressure in ATRIA
● SEMILUNAR VALVES OPEN when
pressure in VENTRICLE EXCEEDS
pressure in ARTERIES
● So blood pushed out of heart
through ARTERIES
Explain the pressure & volume changes and associated valve movements
during the cardiac cycle that maintain a unidirectional flow of blood - Diastole
● Atria & ventricles RELAX
● So their volume INCREASES,
pressure DECREASES
● SEMILUNAR VALVES SHUT when
pressure in ARTERIES EXCEEDS pressure in VENTRICLES
● ATRIOVENTRICULAR VALVES OPEN when pressure in ATRIA EXCEEDS pressure in VENTRICLES
● So blood fills ATRIA via veins &
flows passively to VENTRICLES
Explain how graphs showing pressure or volume changes during the cardiac
cycle can be interpreted, eg. to identify when valves are open / closed
-semilunar valves closed
-semilunar valves opened
-atrioventricular valves closed
-atrioventricular valves open
Semilunar valves closed
● Pressure in [named] ARTERY HIGHER than in VENTRICLE
● To PREVENT BACKFLOW of blood from artery to ventricles
Semilunar valves open
● When pressure in VENTRICLE is HIGHER than in [named] ARTERY
● So blood flows from VENTRICLE to ARTERY
Atrioventricular valves closed
● Pressure in VENTRICLE HIGHER than ATRIUM
● To PREVENT BACKFLOW of blood from ventricles to atrium
Atrioventricular valves open
● When pressure in ATRIUM is HIGHER than in VENTRICLE
● So blood flows from ATRIUM TO VENTRICLE
How can heart rate be calculated from cardiac cycle data?
Heart rate (beats per minute) = 60 (seconds) / length of ONE CARDIAC CYCLE (seconds)