Topic 85-90(Oncogenic DNA Viruses and retroviruses)

Question 0

What happens to the genome pf oncogenic DNA viruses during malignant transformation of cells?

Answer 0

Integrates into the genome of the host cell

Question 1

Name two DNA viruses that can cause human tumors!

Answer 1

• Hepatitis B virus

- Human papilloma virus

Question 2

Name two oncogenic DNA viruses!

Answer 2

• Papilloma virus

- Adenovirus

Question 3

Name the cell in which a DNA virus cause lytic infection!

Answer 3

Permissive cell

Question 4

Which virus has a role in the developement of human cervical carcinoma?

Answer 4

Humann papillomak virus

Question 5

Which virus has a role ino the developement of Burkitt lymphoma?

Answer 5

Epstein-Barr virus

Question 6

Name the DNA copy of the retroviral genome integrated inoto the host cell’s genome!

Answer 6

Provirus

Question 7

Name the enzyme that synthesizes the retroviral provirus!

Answer 7

Reverse transcriptase

Question 8

Name the genes of a weakly oncogenic retrovirus(3)!

Answer 8

• Gag
• Pol
• Env

Question 9

What is v-src?

Answer 9

The oncogene of Rous sarcoma virus

Question 10

What is c-src?

Answer 10

A proto-oncogene homologous to v-src

Question 11

What does the abbreviation LRT stand for?

Answer 11

Long terminal repeat

Question 12

Name two retroviral oncogenes!

Answer 12

• v-src

- v-jun

Question 13

Give an example for a retroviral oncogene lacking a proto-oncogenic equivalent!

Answer 13

No such is known

Question 14

Name an oncogene encoding a non-receptor tyrosine kinase!

Answer 14

Src

Question 15

Name an oncogene encoding a transcription factor!

Answer 15

Jun

Question 16

Name a oncogene encoding a membrane receptor!

Answer 16

erbB

Question 17

Name an oncogene encoding a growth factor!

Answer 17

sis

Question 18

Name those types of genes the mutation of which can contribute to tumor formation! (2)

Answer 18

• Proto oncogenes

- Tumor suppressor genes

Question 19

Name the process by which a retrovirus acquires an oncogene!

Answer 19

Transduction

Question 20

What kind of mutation generates cellular oncogenes?

Answer 20

Gain-of-function mutation

Question 21

What is the common characteristic/function of proto-oncogenic proteins?

Answer 21

They are positive regulators of cell proliferation

Question 22

Name 2 mechanisms that can generate cellular oncogenes!

Answer 22

• Point mutation

- Gene ampliphication

Question 23

Which proto-oncogene family is the most often mutated one in human tumors?

Answer 23

Ras family

Question 24

Name a proto-oncogene which can beactivated by insertional mutagenesis!

Answer 24

Myc

Question 25

What type of mutation causes Burkitt lympphoma?

Answer 25

Reciprocal translocation

Question 26

Name the proto-oncogene activated in Burkitt lymphoma!

Answer 26

Myc

Question 27

Which genes are fused in the philadelphia chromosome?

Answer 27

Bcr/abl

Question 28

Which oncoprotein is the target of Gilvec?

Answer 28

Bcr/Abl fusionl protein

Question 29

What is the mechanism of tumor inductionby weakly onco genic retroviruses?

Answer 29

Insertion mutagenesis

Question 30

What is the mechanism of activation of myc on cogene in neuroblastomas?

Answer 30

Gene amplification

Question 31

Human breast cancer cells often contain an amplified EGF-receptor gene. Name this gene!

Answer 31

HER2/neu

Question 32

What type of breast cancer is sensitive to Herceptin?

Answer 32

Breast tunors with amplification of the HER2/neu gene